Bi/ond

𝗡𝗲𝘄 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗶𝗻𝘁𝗼 𝗗𝘂𝗰𝗵𝗲𝗻𝗻𝗲 𝗠𝘂𝘀𝗰𝘂𝗹𝗮𝗿 𝗗𝘆𝘀𝘁𝗿𝗼𝗽𝗵𝘆 (𝗗𝗠𝗗) 𝗮𝗿𝗲 𝗽𝗼𝘀𝘀𝗶𝗯𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝘂𝘁𝘁𝗶𝗻𝗴-𝗲𝗱𝗴𝗲 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗼𝗻 𝟯𝗗 𝘀𝗸𝗲𝗹𝗲𝘁𝗮𝗹 𝗺𝘂𝘀𝗰𝗹𝗲 𝗺𝗼𝗱𝗲𝗹𝘀! In our latest research study, in collaboration with bit.bio, Bi/ond scientists have discovered how 𝗶𝗼𝗦𝗸𝗲𝗹𝗲𝘁𝗮𝗹 𝗠𝘆𝗼𝗰𝘆𝘁𝗲𝘀 𝗰𝗮𝗻 𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗲 𝟯𝗗 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗺𝗶𝗰𝗿𝗼𝘁𝗶𝘀𝘀𝘂𝗲𝘀, 𝗲𝘅𝗵𝗶𝗯𝗶𝘁𝗶𝗻𝗴 𝘁𝘄𝗶𝘁𝗰𝗵 & 𝘁𝗲𝘁𝗮𝗻𝗶𝗰 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲𝘀 𝘁𝗵𝗮𝘁 𝘀𝘁𝗿𝗲𝗻𝗴𝘁𝗵𝗲𝗻 𝗼𝘃𝗲𝗿 𝘁𝗶𝗺𝗲. This poster highlights the results of their work. What you'll learn: ✅ How iPSC-derived cells were used in the Bi/ond OoC culture system ✅ Functional & phenotypic readouts using the MUSbit™ chip ✅ Real-world applications for disease model research Key Findings: 🔬 Impaired 𝗰𝗼𝗻𝘁𝗿𝗮𝗰𝘁𝗶𝗼𝗻 profiles in DMD models 🔬Functional activity restored through 𝗲𝘅𝗼𝗻 𝗱𝗲𝗹𝗲𝘁𝗶𝗼𝗻𝘀 🔬Advanced in vitro tools for 𝗗𝗠𝗗 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 & 𝗱𝗿𝘂𝗴 𝘀𝗰𝗿𝗲𝗲𝗻𝗶𝗻𝗴 Dive into the full poster for inspiration for your own research!  📥 𝗗𝗼𝘄𝗻𝗹𝗼𝗮𝗱 𝗡𝗼𝘄! https://lnkd.in/eW-fAJmi #DMD #DrugDevelopment #iPSC #OrganOnChip #3DBiology #PharmaResearch #biotech #MUSbit

In an exciting collaboration, Bi/ond and Axol Bioscience Ltd. are pushing the boundaries of #cardiactissue engineering with the development of a robust, physiologically relevant 3D cardiac muscle model. Using Axol’s axoCells™ Ventricular Cardiomyocytes we have successfully established protocols to 𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗲 𝗮𝗻𝗱 𝗰𝗵𝗮𝗿𝗮𝗰𝘁𝗲𝗿𝗶𝘇𝗲 𝗵𝘂𝗺𝗮𝗻 𝟯𝗗 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗺𝘂𝘀𝗰𝗹𝗲 𝘁𝗶𝘀𝘀𝘂𝗲𝘀 𝘁𝗵𝗮𝘁 𝗰𝗹𝗼𝘀𝗲𝗹𝘆 𝗺𝗶𝗿𝗿𝗼𝗿 𝗵𝘂𝗺𝗮𝗻 𝗵𝗲𝗮𝗿𝘁 𝘁𝗶𝘀𝘀𝘂𝗲, within Bi/ond's MUSbit™ platform. 𝗪𝗶𝘁𝗵𝗶𝗻 𝗷𝘂𝘀𝘁 𝟳 𝗱𝗮𝘆𝘀, 𝘄𝗲 𝗺𝗮𝗻𝗮𝗴𝗲𝗱 𝘁𝗼 𝗼𝗯𝘁𝗮𝗶𝗻 𝘀𝗽𝗼𝗻𝘁𝗮𝗻𝗲𝗼𝘂𝘀𝗹𝘆 𝗯𝗲𝗮𝘁𝗶𝗻𝗴 𝗵𝗲𝗮𝗿𝘁 𝘁𝗶𝘀𝘀𝘂𝗲! How did we do it? ❤️𝗠𝗶𝘅𝗶𝗻𝗴 𝘁𝗵𝗲 𝗮𝘅𝗼𝗖𝗲𝗹𝗹𝘀™ 𝗩𝗲𝗻𝘁𝗿𝗶𝗰𝘂𝗹𝗮𝗿 𝗖𝗮𝗿𝗱𝗶𝗼𝗺𝘆𝗼𝗰𝘆𝘁𝗲𝘀 𝘄𝗶𝘁𝗵 𝗽𝗿𝗶𝗺𝗮𝗿𝘆 𝗵𝘂𝗺𝗮𝗻 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗳𝗶𝗯𝗿𝗼𝗯𝗹𝗮𝘀𝘁𝘀 at different ratios we were able to more closely mimic the native state of the heart ❤️The differentiation and maturation into functional ventricular cardiomyocytes were evaluated in a 𝟯𝗗 𝘀𝗲𝘁𝘁𝗶𝗻𝗴 ❤️We studied how the 𝗳𝗶𝗯𝗿𝗼𝗯𝗹𝗮𝘀𝘁𝘀 𝗮𝗳𝗳𝗲𝗰𝘁𝗲𝗱 𝘀𝗲𝗹𝗳-𝗼𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻, 𝗮𝗻𝗱 𝗺𝗮𝗶𝗻𝘁𝗲𝗻𝗮𝗻𝗰𝗲 of the 3D tissues ❤️Through Bi/ond’s MUSbit™ platform, we could also study the 𝘁𝗶𝘀𝘀𝘂𝗲𝘀’ 𝗰𝗼𝗻𝘁𝗿𝗮𝗰𝘁𝗶𝗹𝗲 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲 𝘁𝗼 𝗲𝗹𝗲𝗰𝘁𝗿𝗶𝗰𝗮𝗹 𝗽𝘂𝗹𝘀𝗲 𝘀𝘁𝗶𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻, a technique known as "pacing" ❤️We also analyzed the 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲 𝘁𝗼 𝘀𝗲𝘃𝗲𝗿𝗮𝗹 𝗰𝗮𝗿𝗱𝗶𝗼𝘁𝗿𝗼𝗽𝗶𝗰 𝗱𝗿𝘂𝗴𝘀, a crucial step in validating the model’s 𝘂𝘁𝗶𝗹𝗶𝘁𝘆 𝗳𝗼𝗿 𝗱𝗿𝘂𝗴 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆 𝗮𝗻𝗱 𝘁𝗼𝘅𝗶𝗰𝗼𝗹𝗼𝗴𝘆 𝘀𝘁𝘂𝗱𝗶𝗲𝘀 The goal of this partnership is to provide an enhanced platform for cardiac research, enabling 𝗺𝗼𝗿𝗲 𝗮𝗰𝗰𝘂𝗿𝗮𝘁𝗲 𝘀𝘁𝘂𝗱𝗶𝗲𝘀 𝗼𝗳 𝗵𝗲𝗮𝗿𝘁 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗱𝗿𝘂𝗴 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲𝘀. This model brings us closer to 𝗿𝗲𝗮𝗹𝗶𝘀𝘁𝗶𝗰 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗮𝗻𝗱 𝘀𝗮𝗳𝗲𝗿, 𝗺𝗼𝗿𝗲 𝗲𝗳𝗳𝗲𝗰𝘁𝗶𝘃𝗲 𝗱𝗿𝘂𝗴 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆. Watch our video to see the heart model in action! ❤️ #gobiond #ooc #cardiacmodel #heartbeat #heartcontraction #hearttissue #electricalstimulation #pacing #drugdiscovery #toxicology Read more about our products and applications : https://lnkd.in/e869vNd9

Cake Alert!! 🎂 This week we are celebrating another incredible year of innovation, growth, and impact at Bi/ond. This important milestone in our journey is one filled with ideas, challenges, growth, and amazing people. None of this would be possible without our incredible team, partners, and community who believe in what we do. 𝗧𝗵𝗮𝗻𝗸 𝘆𝗼𝘂 𝗳𝗼𝗿 𝗯𝗲𝗶𝗻𝗴 𝗽𝗮𝗿𝘁 𝗼𝗳 𝗼𝘂𝗿 𝘀𝘁𝗼𝗿𝘆!! Let’s keep building the future, together. #gobiond #Milestone #WorkAnniversary #Innovation #Teamwork #FutureForward

Ready to Dive In? The inCHIPit™, as a prime example of organ-on-chip technology, is designed to provide researchers with a versatile and controllable system for the study of complex 3D tissues. You can transform the way you conduct biomedical research with our most versatile organ on chip device. If you read our earlier posts about inCHIPit™ , https://lnkd.in/ehn8qgyh, we may have triggered your interest to know more about our technology. Check our technical sheet to explore in-depth details about the inCHIPit™, Bi/ond's microfluidic organ-on-chip solution which, in combination with our comPLATE™, can nourish, stimulate and monitor complex 3D tissues. Discover how it can revolutionize your research! 📥 DOWNLOAD here: https://lnkd.in/epqQVSwc #gobiond #OrganOnChip #Ooc #Biotechnology #ResearchInnovation #inCHIPit #CellCulture #3DCellModels #ScientificResearch

As you probably know by now, we like to organize a little team outing from time to time. The team works really hard and this is a way to thank them for all their efforts but also a good opportunity to connect outside of the office and leave behind deadlines, meetings, lab assays and emails. What you may not know is that these team building activities are normally organized by one of us and we like to keep them a surprise to everyone else. We may get a few hints so that we are not totally unprepared, but basically it is just a date, time, and a couple of words. The keywords for our latest activity were: outside; no need for gym clothes; no open shoes. Would you have guessed what Nikolas put us up to? (spoiler alert, one of us did ;)) It was certainly a great workout, a way to release some stress and frustrations, and a lot of fun together! Go Bi/ond! #gobiond #teambuilding #team #fun #outdoorsfun #outoftheoffice 

Do you want to see a few snapshots of our new pump main features? If you are looking for a pump that you can work with inside an incubator, with pre-arranged culture protocols and recirculation capabilities, search no further : 𝗰𝗲𝗹𝗹𝗗𝗥𝗜𝗩𝗘™ is going to become your microfluidic pump choice for OoC studies. PS: If you have no idea what we are talking about, check out our announcement post :) https://lnkd.in/eCtn2c8i #gobiond #microfluidicpump #keyfeatures #celldrive #ooc #pump 

You may remember we recently shared about our collaboration with Università degli Studi di Perugia, where Prof. Guglielmo Sorci's team is researching the role of the 𝗥𝗔𝗚𝗘 𝗿𝗲𝗰𝗲𝗽𝘁𝗼𝗿 𝗶𝗻 𝗰𝗮𝗻𝗰𝗲𝗿-𝗶𝗻𝗱𝘂𝗰𝗲𝗱 𝗰𝗮𝗰𝗵𝗲𝘅𝗶𝗮, as an ultimate research goal. During her time at Bi/ond, Giulia Gentili started up the first steps towards the establishment of a cachexia model. The experiments were geared towards setting up 𝗰𝗼-𝗰𝘂𝗹𝘁𝘂𝗿𝗲𝘀 𝗼𝗳 𝗯𝗼𝘁𝗵 𝘀𝗸𝗲𝗹𝗲𝘁𝗮𝗹 𝗺𝘂𝘀𝗰𝗹𝗲 (𝗖𝟮𝗖𝟭𝟮) 𝗮𝗻𝗱 𝘁𝘂𝗺𝗼𝗿 (𝗟𝗲𝘄𝗶𝘀 𝗟𝘂𝗻𝗴 𝗰𝗮𝗿𝗰𝗶𝗻𝗼𝗺𝗮) 𝗰𝗲𝗹𝗹𝘀. We are happy to report that co-culture was successfully obtained both at the well and the channel level! The images below show the results of the study, where you can see the staining of both cell types (magenta - muscle specific - and green - both cell types*) as 𝘁𝗵𝗲𝘆 𝗮𝗿𝗲 𝗴𝗿𝗼𝘄𝗶𝗻𝗴 𝘁𝗼𝗴𝗲𝘁𝗵𝗲𝗿. These preliminary results show great potential for the team's objectives! 𝗪𝗵𝗮𝘁 𝗶𝘀 𝗻𝗲𝘅𝘁? ✅ further investigate with contraction forces - showing muscle weakness/loss of contraction ✅combine the muscle tissue with tumor cells that overexpress RAGE vs normal tumor cells to see what the effect on the muscle tissue is. We look forward to supporting the team at Perugia in these next steps and seeing more awesome co-culture results! * Magenta = sarcomeric alpha-actinin. Green = F-actin #gobiond #collaboration #coculture #musclecells #tumorcells #caxechia #RAGE

Welcome Vishnu to our team! Vishnu Balaji joins Bi/ond to strengthen our biolab team. Vishnu has experience with #skeletal #muscle differentiation and a passion for replicating physiologically accurate #tissue and #organmodels using advanced fabrication technologies. With a Master of Science in Regenerative Medicine and Technology from Utrecht University, Vishnu’s academic journey focused on biofabrication and its potential in #regenerative therapies. His work centered on engineering cells and their microenvironments to replicate complex #3D tissues #invitro, aligning perfectly with our mission. We’re thrilled to have Vishnu on board and look forward to advancing personalized medicine together, reducing the reliance on animal testing through his insights and innovative approach! #gobiond #newteamember #welcometotheteam #hr #newhire

𝗢𝘂𝗿 𝗷𝗼𝘂𝗿𝗻𝗲𝘆 𝘀𝗼 𝗳𝗮𝗿... From groundbreaking innovations to team adventures, take a peek into how Bi/ond has evolved over the years. This video captures the heart of what we do —both in the lab and beyond! 🎬 Watch now and see how we’re advancing technology while building a vibrant, collaborative workplace. #gobiond #tbt #InnovationInAction #TeamCulture #GrowingTogether #LifeAtBiond

𝗖𝗼-𝗰𝘂𝗹𝘁𝘂𝗿𝗲 𝗼𝗳 𝗰𝗮𝗿𝗱𝗶𝗼𝗺𝘆𝗼𝗰𝘆𝘁𝗲𝘀 𝗮𝗻𝗱 𝗲𝗻𝗱𝗼𝘁𝗵𝗲𝗹𝗶𝗮𝗹 𝗰𝗲𝗹𝗹𝘀 𝘁𝗼 𝗶𝗺𝗽𝗿𝗼𝘃𝗲 𝗺𝗮𝘁𝘂𝗿𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗿𝗲𝗹𝗲𝘃𝗮𝗻𝗰𝗲 This group of researchers (see below) have developed a 𝗰𝘂𝘁𝘁𝗶𝗻𝗴-𝗲𝗱𝗴𝗲 𝗵𝘂𝗺𝗮𝗻 𝗰𝗲𝗹𝗹-𝗯𝗮𝘀𝗲𝗱 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝘁𝗶𝘀𝘀𝘂𝗲 𝗺𝗼𝗱𝗲𝗹 𝘁𝗵𝗮𝘁 𝗯𝗿𝗶𝗱𝗴𝗲𝘀 𝘁𝗵𝗲 𝗴𝗮𝗽 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗶𝗻 𝘃𝗶𝘁𝗿𝗼 𝘀𝘁𝘂𝗱𝗶𝗲𝘀 𝗮𝗻𝗱 𝗿𝗲𝗮𝗹-𝘄𝗼𝗿𝗹𝗱 𝗵𝘂𝗺𝗮𝗻 𝘀𝗲𝘁𝘁𝗶𝗻𝗴𝘀. 🫀 ***KEY FINDINGS*** 𝗔𝗱𝘃𝗮𝗻𝗰𝗲𝗱 𝗠𝗮𝘁𝘂𝗿𝗮𝘁𝗶𝗼𝗻: The cardiac tissue model shows improved maturity and physiological relevance, making it more representative of human cardiac tissue. 𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹𝗶𝘁𝘆 𝗖𝗼𝗻𝗳𝗶𝗿𝗺𝗮𝘁𝗶𝗼𝗻: The model’s functionality was confirmed by assessing the effects of 32 compounds using multielectrode arrays. It predicted cardiac effects with impressive accuracy (91%), sensitivity (90%), and specificity (100%). 𝗧𝗿𝗮𝗻𝘀𝗳𝗲𝗿𝗮𝗯𝗶𝗹𝗶𝘁𝘆 𝘁𝗼 𝗛𝘂𝗺𝗮𝗻 𝗦𝗲𝘁𝘁𝗶𝗻𝗴𝘀: The standardized model allows accurate translation of in vitro data to human contexts, making it highly valuable for biomedical research and cardiotoxicity testing. 📚 Read the full article here: 𝙁𝙪𝙣𝙘𝙩𝙞𝙤𝙣𝙖𝙡 𝙝𝙪𝙢𝙖𝙣 𝙘𝙚𝙡𝙡-𝙗𝙖𝙨𝙚𝙙 𝙫𝙖𝙨𝙘𝙪𝙡𝙖𝙧𝙞𝙨𝙚𝙙 𝙘𝙖𝙧𝙙𝙞𝙖𝙘 𝙩𝙞𝙨𝙨𝙪𝙚 𝙢𝙤𝙙𝙚𝙡 𝙛𝙤𝙧 𝙗𝙞𝙤𝙢𝙚𝙙𝙞𝙘𝙖𝙡 𝙧𝙚𝙨𝙚𝙖𝙧𝙘𝙝 𝙖𝙣𝙙 𝙩𝙚𝙨𝙩𝙞𝙣𝙜 https://lnkd.in/euYHpSGK 𝗟𝗲𝘁’𝘀 𝗰𝗼𝗻𝘁𝗶𝗻𝘂𝗲 𝗮𝗱𝘃𝗮𝗻𝗰𝗶𝗻𝗴 𝘀𝗰𝗶𝗲𝗻𝗰𝗲 𝘁𝗼𝗴𝗲𝘁𝗵𝗲𝗿! Authors : Maria Koivisto, Tuomas Tolvanen, Tarja Toimela, Ilkka Miinalainen, Antti Kiviaho, Juha Kesseli, @Matti Nykter, @Lauri Eklund & Tuula Heinonen #BiomedicalResearch #CardiacHealth #StemCells #ScienceAdvances