Genuine surprise and happiness from Noé & Daniel as Cradle is announced as the winner of the 'Next Global Hot Thing In AI' during the swissICT Digital Economy Award Gala in Zurich last night ❤️
Over ons
We believe Cells can theoretically produce almost anything, from fabrics to food, fuel and medicines. Designing cell-factories is hard, but our tools and machine-learning models can make it easier. Our mission is to ultimately help replace traditional farms and factories for a more sustainable world. Jobs: https://jobs.cradle.bio
- Website
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http://www.cradle.bio
Externe link voor Cradle
- Branche
- Biotechnologie
- Bedrijfsgrootte
- 11 - 50 medewerkers
- Hoofdkantoor
- Amsterdam
- Type
- Particuliere onderneming
- Opgericht
- 2021
- Specialismen
- protein design, machine learning, protein activity, protein stability, protein secretability, protein , protein structure, metabolic engineering, protein engineering en protein solubility
Locaties
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Primair
Routebeschrijving
Amsterdam, NL
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Routebeschrijving
Zurich, CH
Medewerkers van Cradle
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Tilke Judd
Founding Product Manager @ Cradle | ex-Google | MIT PhD
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Nick Lenten
Founder & CEO Ahead | ex-CPO Google Flights and Coolblue
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Cynthia Jurytko
Corporate Strategy | Founder of Venture Capital Fund | Venture Partner for M&A & Exit Strategy, Fundraising , Investments | Angel Investor & LP
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Noé Lutz
Senior Engineering Leader | Machine Learning and Security Expert | Xoogler
Updates
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🔥 There’s a shortage of public NGS (next-generation sequencing) datasets. It’s holding back the entire field. We want to fix that. In recent experiments, we’ve shown that combining NGS data with AI can generate antibody sequences with 30% amino acid variation while maintaining strong binding affinity. So we’re building a high-quality, open data resource for the scientific community. And we need YOUR help 🫵 Calling all researchers! 👩🔬 👨🔬 Submit your antibody targets that are: ✅ Protein/peptide-based ✅ Stable & soluble ✅ Safe to handle ✅ Manufacturing-friendly We’ll handle the experiments and publish all data openly for anyone to use and build upon. Let’s accelerate the development of better drugs!
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Help us identify targets for our upcoming campaign of panning+NGS studies for antibodies! We'll publish the results for everyone to use, so we'd love suggestions where the data could also help tackle understudied diseases.
Just back from PEGS Europe in Barcelona, where we showed something we’re super excited about: Cradle-Sponsored Panning Studies – by the community for the community! If you missed our poster presentation at PEGS, here’s what it’s all about: Our ML models achieved remarkable results after training on NGS data from a panning experiment in one of our recent antibody optimization projects. There’s just one issue: Public NGS data of panning experiments are scarce. So we’re changing that together with the community! Here’s how it works: 1. Submit your most interesting target(s). 2. We select a few winning targets. 3. Cradle sponsors and organizes the panning studies. 4. The NGS data and results get published, open for everyone to access and build with. To contribute, submit your target here: https://lnkd.in/eZF_BZ_Y /Cradle
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Want to see how we're designing antibodies despite limited data? We're excited to discuss how we bootstrap training data for our active learning optimization pipeline. This approach also surprisingly achieved a 9-fold improvement in binding affinity for SARS-CoV-2 RBD! Join Nicolas and Jonathan at RosettaCon (November 11-13). They will be presenting their work at poster 103 and 66 respectively. They are happy to discuss their learnings!
How do you start optimizing an antibody with ML if all you have is a lead and no assay data? Jonathan D. Ziegler and I will be at RosettaCon in Copenhagen from 11 to 13 November to talk about how we generate variants that serve as training data, and sometimes happen to drastically improve affinity. We'll be presenting our in-vitro evaluation of different approaches in poster No. 103 on Tuesday 12th. Come meet us at the Copenhagen Biocenter if you are curious about ML in protein design, happy to discuss our learnings here at Cradle.
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Cradle will attend PEGS Europe in Barcelona next week (November 5-7th)! 🎤 Join Stef (CEO & cofounder) on Wednesday November 6th at 14:50 when he discusses several real-world antibody, vaccine and enzyme case studies to highlight which limitations Cradle had to overcome to build a robust, scalable and easy-to-use generative system for protein design 🤓 Visit Poster B033 (or ping us) to nerd out about multi-property, multi-stage generative protein design with Harmen (Head of Bioengineering & cofounder), Richard (Scientist - Bioengineering), Jinel (Scientist - Bioengineering), Jonathan (Scientist - Machine Learning), Tilke (Head of Product) and Thijs (Partnerships) ☕ Ping Thijs (Partnerships) at thijs@cradle.bio if you're interest to learn how to get started with Cradle's generative ML platform. #PEGSEurope #generative #AI #ML #proteins #biologics #conference
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We held a protein-engineering challenge at iGEM, and it was a lot of fun 🔥❤️
We just wrapped up an amazing protein engineering challenge at IGEM, one of my favourite events of the year. Our booth was full of students eager to try their hand at designing thermally stable proteins, which would be judged by Cradle's AI models (predictor models that predict thermostability). Over 100 students jumped into the challenge, and it was super inspiring to see their strategies. Some fired up PyMOL for rational design, while others gambled with random mutations. Then there were the creative hackers - one team found a thermostable protein in the literature and practically rewrote it, another maxed out their design with disulfide bonds, and the University of Münster team even spent the night training on a public thermostability dataset! The University of Pisa dominated much of day two, collaborating as a team to combine beneficial mutations and holding the top three spots. But then came the final sprint - Nienke IJspeert from Leiden University showed up with some smart rational nanobody designs that, while landing in fourth place, sparked renewed motivation. Inspired by this, Matias Brezina Borges from University of Munich (who wished he'd found us sooner!) dove into PyMOL and produced our winning design. Second place went to a great collaborative effort - we gave Michel Stevens from University of Münster another shot after seeing how much work he'd put in with his teammates (they even used their own models!). They grabbed silver, while Riccardo Masetti from University of Pisa held onto third place. It was a lot of fun to see the excitement around the challenge and Cradle's approach - we spent every minute talking about models and throughput. Between the creative strategies, overnight modeling attempts, and last-minute victories, we couldn't have asked for a better way to showcase protein engineering at IGEM. Congrats to the winners! If you want to know more about protein engineering and how we do it at Cradle, stop by the talk with Daan van der Vorm and me tomorrow at Plaza 3 at 12:45!
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"AI is reshaping software, both in how it's written and what it can do. This is creating new opportunities for growth and efficiency, and tackling novel challenges. This impact will only increase in the years to come." -- Accel Accel has released its Euroscape 2024 report, an annual overview of the top 100 European companies valued under $1 billion (includes Cradle ❤️). A key insight from the report is the increasing traction of vertical AI applications among enterprise users, i.e. AI x Biotech. As the report suggests, this intersection of specialized knowledge and AI is will drive significant innovation in the coming years. 👉 report: https://lnkd.in/eSpyZTdg
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Stef will be in London next week for Benchling's Benchtalk! He will be participating in a panel discussion on 'Accelerating R&D with AI'. Session is Wednesday, October 23rd, 10:55 AM at the Convene Space. Pierre Salvy, CTO at Cambrium and Stef will discuss how companies can turn the omnipresent conversations about AI into concrete projects, and the key role that data quality plays when it comes to operational success. If you're interested in attending, you can register here: https://lnkd.in/dWqVGp4J
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There are many 'Hot Startups Lists', but WIRED's Top 100s will always have a special place in our heart. This time we're celebrating being featured amongst the amazing startups in Europe, and a special section dedicated to Amsterdam's ecosystem. (Did you know there are more than 4000 startups in Amsterdam?) Wired notes that what sets Amsterdam apart is its strong focus on tackling urgent societal issues and global challenges. From energy transition to pollution, climate change and addressing the needs of a growing population, Amsterdam's startups are increasingly innovating with a strong purpose. Hence our friends from Amsterdam that were also selected for the list: Overstory: Using satellite imagery to prevent power outages and wildfires. Monumental: Revolutionizing construction with autonomous bricklaying robots. Carbon Equity: Democratizing access to climate tech investments. Coolgradient: Optimizing data center energy efficiency. Weaviate: Powering AI applications with vector database technology. Bloom & Wolf: Offering sustainable alternatives to traditional cut flowers. Solvimon: Streamlining billing for fintech and SaaS businesses. Haaven: Simplifying the process of building eco-friendly tiny houses. Keep it going! 🚀
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