Technobis Crystallization Systems

Proud to be among the sponsors for the upcoming 10th Winter Process Chemistry Conference organised by Scientific Update Ltd! Come say hi to our colleague Sarah Thompson and learn how the #ReactALL innovative benchtop multiple reactor system with automated sampling and overhead stirring can accelerate your process chemistry research. See you there? #Technobis #ScientificUpdate #WinterProcessChemistry #ReactionScreening #ReactionOptimization #ReactionProfiling #ReactionKinetics #ProcessChemistry #ChemicalSynthesis

Excited to be at CPHI & PMEC India with our distribution partner Spinco Biotech.👋 Come say hi at booth C41 in Hall 11! This is the perfect opportunity to see the #Crystal16 and #Crystalline in action, and understand how they can help your research succeed! #Technobis #Spinco #CPHIIndia2024 #PMECIndia2024 #Crystallization #SolidStateResearch #Formulation #ProcessDevelopment #ChemicalSynthesis #ProcessChemistry #LaboratoryTechnology #LabInnovation #LabAutomation

The future of reaction screening is here.   Discover how Technobis Group, a Dutch-based world-leading laboratory technology provider, helps scientists globally become more successful and efficient.   Learn how the game-changing ReactALL™ empowers process chemists to successfully screen and optimize their research. Hear from John de Kok, CEO ; Stephan Van Banning, CTO; and Carmen Guguta, Global Head of Business Development and Marketing at Technobis.   Read the full article on the website and subscribe to receive the magazine by mail or digitally. https://lnkd.in/e_zcZJZh   Follow us on LinkedIn to stay up to date with interesting sector news and posts.   BiotechNEWS & Life Sciences is the magazine that provides the Dutch Life Sciences sector with sector news and updates on the latest developments and interesting trends. The next edition will be printed in November. For advertising and publishing opportunities contact us at biotechnews@hyphenprojects.nl. 

Attending CPHI & PMEC India next week? Come say hi to our distribution partner Spinco Biotech! Their expert team will be showcasing our solutions in chemical synthesis, solid-state research, process development and formulation. Visit them at booth C41 in Hall11 to discuss your specific research needs or challenges, and see how together we can help your efforts succeed! #Technobis #Spinco #CPHIIndia2024 #PMECIndia2024 #Crystallization #SolidStateResearch #Formulation #ProcessDevelopment #ChemicalSynthesis #ProcessChemistry #LaboratoryTechnology #LabInnovation #LabAutomation

LATER EDIT: The webinar has been rescheduled to: 🗓 Date: Thursday, March 20, 2025 🕔 Time: 4.00 pm CET | 10.00 am EST | 7.00 am PST | 8.30 pm IST We hope to see you then! --- 📢 Upcoming webinar! Discover how understanding the characterization, solubility and hygroscopicity of a pharmaceutical compound can transform pharmaceutical development. Our guest speaker Martha Grover from Georgia Institute of Technology will share insights into her recent explorations of BMS-817399, a compound used as an active pharmaceutical ingredient (API), finding that its monohydrate form (Form 1) shifts with humidity and temperature. By targeting a stable form, Martha and her research colleagues discovered a new anhydrous variant (Form 2) through controlled crystallization. This form resists environmental changes more effectively, promising improved API performance. 🗓 Date: Tuesday, December 3, 2024 🕔 Time: 4.00 pm CET | 10.00 am EST | 7.00 am PST | 8.30 pm IST Participation is free. Register here: https://lnkd.in/dMhn9SVy Read more about the webinar topic and guest speaker here: https://lnkd.in/d6JMvjXh #Technobis #Webinar #Solubility #Pharmaceuticals #APIs #PharmaceuticalDevelopment

🚀 Route scouting in heterogeneous reactions with #ReactALL™ 🚀 Optimizing complex chemical reactions is essential for industries like #pharmaceuticals and #fine #chemicals, where precision and efficiency drive innovation. Our latest application note highlights the advanced capabilities of the ReactALL system in simplifying route scouting for solid-liquid reactions and streamlining process development. The ReactALL system is an advanced platform for chemical reaction screening, featuring #SmartCap technology with automated sampling, quenching, and dilution for streamlined HPLC vial transfer and high-quality data. 🔬 Key Findings: ➡️ The N-methylation of 1-phenylpiperazine with potassium carbonate in 2-methyltetrahydrofuran was tested in three setups: ReactALL, an overhead stirrer, and a vial with magnetic stirring at 500 rpm and 25°C. ➡️ ReactALL provided superior mixing and consistent conversion, matching the performance of larger commercial reactors, while the vial with magnetic stirrer gave inaccurate results. ➡️ ReactALL also enabled precise #chemoselectivity and real-time data through automated sampling. Thanks to Hawkins et al. for the insightful work published in Organic Process Research & Development! 📄 Read more in the application note: https://lnkd.in/dxYeSFsg #Technobis #ReactionScreening #ProcessChemistry #Automation #AutomatedSampling #HomogeneousReaction #HeterogeneousReaction #Reproducibility

🚀 Rapid determination of activation parameters with #ReactALL™ 🚀 Understanding activation parameters is crucial for optimizing reaction efficiency in chemical process development. Our latest application note highlights the ReactALL system's capabilities in investigating kinetic parameters, using the nucleophilic aromatic substitution (SNAr) reaction between 2,4-difluorobenzonitrile and 1-phenylpiperazine. The ReactALL platform, with #SmartCap technology with automated sampling, quenching, and dilution, enables streamlined HPLC vial transfer and high-quality data. Its precise control and automation allow efficient data collection across varying temperatures and concentrations, providing valuable kinetic insights. 🔬 Key Findings: ➡️ The SNAr reaction was studied by varying temperatures (32-80°C) and concentrations at a constant 56°C. The system’s five independent reactors facilitated parallel testing, allowing for temperature-dependent kinetics. ➡️ The reaction was first-order in both electrophile and nucleophile, but zeroth-order in the base. Selectivity favored the Para-1 product over Ortho-1 with a 7:1 ratio. ➡️ Eyring analysis revealed activation enthalpies of 9.7 kcal/mol for Para-1 and 10.2 kcal/mol for Ortho-1. This study emphasizes the efficiency of ReactALL in providing reliable, high-quality kinetic data, proving its utility for optimizing industrial processes. Thanks to Hawkins et al. for the insightful work published in Organic Process Research & Development! 📄 Read more in our application note: https://lnkd.in/dScegbYC #Technobis #ProcessOptimization #ReactionKinetics #SNAr #Nucleophilic #AutomatedSampling #ActivationParameters #ReactionEngineering

🚀 #ReactALL: Enhancing solvent retention with #SmartCap technology 🔬 A recent study on the ReactALL system, featuring SmartCap technology, has demonstrated its ability to significantly reduce solvent evaporation, thus solving a major issue in maintaining consistency during experiments. The ReactALL system is an advanced platform for chemical reaction screening, featuring #SmartCap technology to reduce solvent evaporation, with automated sampling, quenching, and dilution for streamlined HPLC vial transfer and high-quality data. 🔬 Key Findings: ➡️ Assessment without sampling: THF was heated under reflux for 20 hours in sealed reactors with no solvent loss, demonstrating the system's efficiency in static conditions. ➡️ Assessment with repeated sampling: Multiple solvents, including MTBE, THF, ethyl acetate, and toluene, were heated to their boiling points with 16 samples taken. Minimal solvent loss (2.1% to 6.6%) was observed, except for MTBE, which had a 13% loss. The retention performance during active sampling highlights how SmartCap technology preserves solvent integrity and prevents evaporation, ensuring precise concentration control for improved reproducibility and accuracy in reaction profiling. Thanks to Hawkins et al. for the insightful work published in Organic Process Research & Development! 📄 Read more here: https://lnkd.in/dePRH7pp #Technobis #ReactionScreening #ReactionProfiling #SolventRetention #AutomaticSampling #ProcessDevelopment #OrganicChemistry

Come meet us in #SanDiego at #AIChE2024! Bring your questions about #chemical #synthesis, #solid-state research, process development, and #formulation to booth #622. Our colleagues Fernando Ferreira, MBA and Carmen Guguta will be there to provide support on how to make your research successful. In addition, if you are interested in learning more about our latest device, the #ReactALL benchtop multiple reactor system for chemical process R&D, now is the perfect time to do so. ReactALL will be displayed and available for live demos during the event. See you there?

🚀 ReactALL: Ensuring reproducibility with automated sampling 🚀 Reproducibility is a cornerstone of successful chemical process scale-up, ensuring that representative aliquots are consistently achieved. The #ReactALL system is an advanced platform for chemical reaction screening, featuring #SmartCap technology with automated sampling, quenching, and dilution for streamlined HPLC vial transfer and high-quality data. We highlight a recently conducted study by a research team at Pfizer, comparing manual and automated sampling methods, and the results speak for themselves. 🔬 Key Findings: ➡️ Homogeneous System: A solution of diphenyl ether in acetonitrile was agitated in five reactors at 500 rpm and 25°C. ReactALL’s automated sampling showed consistent UPLC-MS data with a residual standard deviation of 0.8%-1.5%, closely matching manual sampling (1.4%), confirming its precision and reproducibility. ➡️ Heterogeneous System: A mixture of diphenyl ether and sodium tosylate in toluene was tested under similar conditions. Automated and manual samples yielded nearly identical results, proving the effectiveness of ReactALL in handling both soluble and insoluble components. Thanks to Hawkins et al. for the insightful work published in Organic Process Research & Development! 📄 Read more here: https://lnkd.in/d75V2KhJ #Technobis #ReactionScreening #ProcessChemistry #Automation #AutomatedSampling #HomogeneousReaction #HeterogeneousReaction #Reproducibility