Epigenomystiq

𝐀𝐍 𝐈𝐓𝐀𝐋𝐈𝐀𝐍-𝐈𝐍𝐒𝐏𝐈𝐑𝐄𝐃 𝐍𝐄𝐎-𝐑𝐄𝐍𝐀𝐈𝐒𝐒𝐀𝐍𝐂𝐄 𝐈𝐍 𝐄𝐏𝐈𝐆𝐄𝐍𝐎𝐌𝐄 𝐄𝐃𝐈𝐓𝐈𝐍𝐆 We're all familiar with the irresistible charm of Italian cuisine—lasagna, ravioli, pizza, pasta, ribollita, arancini, carbonara, risotto, mamma mia!!! Something beautiful indeed! The Italian cities, architecture, art, climate, beaches, & wine—the list goes on. I could chat about it endlessly—while savoring my double espresso. However, Italy is about to gain fame for another captivating achievement. This time—the team of brilliant Scientists from San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) (IRCCS San Raffaele Scientific Institute) has achieved the unimaginable! Forget genome editing & "CRISPR revolution"—we're entering the neo-renaissance of Epigenome Editing. Straight from the heart of Milan—their study lays the groundwork for the development of in vivo therapeutics based on epigenetic silencing. Enjoy the read... Or, as I should have said, "Buona Lettura!" Ciao! ~~~ We're 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐲𝐬𝐭𝐢𝐪, & talk about: #precisionmedicine #epigenomics #genetherapy #epigenetics #genomics #singlecell #genetics #science Transcend the Border of your 𝐃𝐍𝐀-𝐁𝐥𝐮𝐞𝐩𝐫𝐢𝐧𝐭. Let 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐲𝐬𝐭𝐢𝐪 be your Guide. 𝐄𝐧𝐥𝐢𝐠𝐡𝐭𝐞𝐧 𝐭𝐡𝐞 𝐃𝐚𝐫𝐤—𝐰𝐡𝐞𝐫𝐞 𝐌𝐲𝐬𝐭𝐢𝐪𝐮𝐞 𝐚𝐛𝐢𝐝𝐞𝐬...

𝐌𝐚𝐩𝐩𝐢𝐧𝐠 𝟑𝐃 𝐜𝐡𝐫𝐨𝐦𝐚𝐭𝐢𝐧 𝐭𝐨𝐩𝐨𝐥𝐨𝐠𝐲 𝐚𝐧𝐝 𝐠𝐞𝐧𝐞 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧 𝐰𝐢𝐭𝐡 "𝐞-𝐇𝐢𝐏-𝐇𝐨𝐏" Check out this newly available resource in epigenomics. 𝐇𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭𝐬: • Researchers developed e-HiP-HoP (Highly Predictive Heteromorphic Polymer). It's a computational model for predicting 3D human chromatin structure. In fact, it tackles the limitations of existing experimental technologies like FISH & Hi-C. • The model introduces a new structural unit called a "topos," representing the regulatory landscape around gene promoters. e-HiP-HoP successfully predicted the 3D structure of over 10,000 active gene topoi in GM12878 lymphoblastoid cells. • e-HiP-HoP incorporates key biophysical principles of chromosome organization. That includes multivalent chromatin-binding protein interactions, loop extrusion by cohesin, & chromatin heteromorphism. • Data mining revealed folding motifs linked to Gene Ontology features & identified "influential nodes" — chromatin sites that frequently interact with gene promoters and drive structural diversity. The framework actually provides a mechanistic basis for understanding chromatin contact networks & their relationship to gene function. e-HiP-HoPv offers now a novel approach to modeling high-resolution chromatin structure. I included the reference & link to the "3DGene: Gene Structure Database" in the comments. Please have a look at it. --- We're 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐲𝐬𝐭𝐢𝐪, & talk about: #precisionmedicine #epigenomics #genetherapy #epigenetics #genomics #singlecell #genetics #science Transcend the Border of your 𝐃𝐍𝐀-𝐁𝐥𝐮𝐞𝐩𝐫𝐢𝐧𝐭. Let 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐲𝐬𝐭𝐢𝐪 be your Guide. 𝐄𝐧𝐥𝐢𝐠𝐡𝐭𝐞𝐧 𝐭𝐡𝐞 𝐃𝐚𝐫𝐤—𝐰𝐡𝐞𝐫𝐞 𝐌𝐲𝐬𝐭𝐢𝐪𝐮𝐞 𝐚𝐛𝐢𝐝𝐞𝐬...

𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐝𝐫𝐮𝐠 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: 𝐂𝐞𝐥𝐞𝐛𝐫𝐚𝐭𝐢𝐧𝐠 𝐬𝐮𝐜𝐜𝐞𝐬𝐬𝐞𝐬 𝐚𝐧𝐝 𝐜𝐨𝐧𝐟𝐫𝐨𝐧𝐭𝐢𝐧𝐠 𝐟𝐚𝐢𝐥𝐮𝐫𝐞𝐬 — 𝐚𝐫𝐞 𝐰𝐞 𝐩𝐮𝐥𝐥𝐢𝐧𝐠 𝐭𝐡𝐞 𝐫𝐢𝐠𝐡𝐭 𝐬𝐭𝐫𝐢𝐧𝐠𝐬 𝐨𝐟 𝐭𝐡𝐞 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞? Drug discovery has always been a challenging & costly process. While it often takes way over a decade to turn an idea into a ready-to-use treatment (if you’re lucky...). Along the way, it’s crucial to attract others to your vision & build a team that can help translate that vision from the lab (the "bench") to patients (the "bedside"). Well, developing new drugs requires a lot of patience, perseverance, sacrifice, & resilience in the face of failure. The reality that 90% of drugs fail in clinical trials doesn’t make it any easier. Therefore, you need strong motivation, a clear purpose, & a backup plan in case you don’t land in that fortunate 10%. After 10 to 15 years, you’ll find yourself in a very different place in life. The world is evolving alongside you. Technology is advancing, & so is Science itself. Sometimes your initial ideas about what can be a good target might be totally wrong in light of new scientific evidence. This is especially true when you design drugs that target gene regulatory elements &/or components that form the epigenome of cells. I came across a great review that outlines efforts in developing epigenetic drugs over the past few decades. It is full of valuable lessons & truly inspirational. In the end, it provoked me to raise the question of whether we are pulling the right strings of the Epigenome... It also provides some hints on what we could do differently. Please give it a read! --- Thank you so much for reading. Wish to learn more? Hit the 𝐅𝐨𝐥𝐥𝐨𝐰 [👥👋🏼] — you'll never miss out on the latest 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 news 🎯! Give it a like [👍🏼] or share [🕊️] the post to spread this Epi-message 💌. I'm 𝐃𝐚𝐦𝐢𝐚𝐧, & I talk about: #precisionmedicine #epigenetics #genomics #singlecell #genetics #science #health — Always be on top of your DNA!

𝐌𝐚𝐩𝐩𝐢𝐧𝐠 𝟑𝐃 𝐜𝐡𝐫𝐨𝐦𝐚𝐭𝐢𝐧 𝐭𝐨𝐩𝐨𝐥𝐨𝐠𝐲 𝐚𝐧𝐝 𝐠𝐞𝐧𝐞 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧 𝐰𝐢𝐭𝐡 "𝐞-𝐇𝐢𝐏-𝐇𝐨𝐏" Check out this newly available resource in epigenomics. 𝐇𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭𝐬: • Researchers developed e-HiP-HoP (Highly Predictive Heteromorphic Polymer). It's a computational model for predicting 3D human chromatin structure. In fact, it tackles the limitations of existing experimental technologies like FISH & Hi-C. • The model introduces a new structural unit called a "topos," representing the regulatory landscape around gene promoters. e-HiP-HoP successfully predicted the 3D structure of over 10,000 active gene topoi in GM12878 lymphoblastoid cells. • e-HiP-HoP incorporates key biophysical principles of chromosome organization. That includes multivalent chromatin-binding protein interactions, loop extrusion by cohesin, & chromatin heteromorphism. • Data mining revealed folding motifs linked to Gene Ontology features & identified "influential nodes" — chromatin sites that frequently interact with gene promoters and drive structural diversity. The framework actually provides a mechanistic basis for understanding chromatin contact networks & their relationship to gene function. e-HiP-HoPv offers now a novel approach to modeling high-resolution chromatin structure. I included the reference & link to the "3DGene: Gene Structure Database" in the comments. Please have a look at it. --- Thank you so much for reading. Wish to learn more? Hit the 𝐅𝐨𝐥𝐥𝐨𝐰 [👥👋🏼] — you'll never miss out on the latest 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 news 🎯! Give it a like [👍🏼] or share [🕊️] the post to spread this Epi-message 💌. I'm 𝐃𝐚𝐦𝐢𝐚𝐧, & I talk about: #precisionmedicine #epigenetics #genomics #singlecell #genetics #science #health — Always be on top of your DNA!

𝐂𝐚𝐧 𝐦𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐡𝐨𝐥𝐨𝐠𝐫𝐚𝐦𝐬 𝐫𝐞𝐜𝐨𝐧𝐬𝐭𝐫𝐮𝐜𝐭 𝐭𝐡𝐞 𝐬𝐩𝐚𝐭𝐢𝐨𝐭𝐞𝐦𝐩𝐨𝐫𝐚𝐥 𝐝𝐲𝐧𝐚𝐦𝐢𝐜𝐬 𝐨𝐟 "𝐋𝐢𝐟𝐞"? I've come across news several times about an impending "holographic revolution." It seems to center on creating "exceptional" 3D representations of ourselves in virtual reality & similar technologies. While I don't want to sound pessimistic about this development... I prefer experiencing real interactions over those with virtual or artificial representations of myself & others. Even if this technology enables me to "bilocate"— allowing me to be omnipresent at multiple conferences happening simultaneously across different continents. That's too much, thank you. I'm concerned that this could lead to even less genuine human connection & greater isolation. While we often assert that our civilization is more connected than ever, but is this really the case? That said, however, I see real potential for holography in biomedical fields. For instance, I would be thrilled to see molecular holograms depicting the dynamics of gene expression in my heart, brain, or skin. Watching these changes in real time would be mind-blowing. This advancement wouldn't just be entertaining. It would be invaluable for scientists who currently rely on snapshots of genetic activity. Unfortunately, no system similar to "AlphaFold" currently exists. It is hard to predict the spatiotemporal dynamics of gene activity in humans. A few photos can rarely capture the full story. Just as your vacation album can only hint at the richness of the experience for those who weren't there. In fact, only you can truly recall the full depth of those lasting memories. For that reason, we really need such holograms in genomics space. They would help us reconstruct the molecular events happening during Life. You can only imagine what we scientists could achieve with such a tool for creating molecular holograms in health & disease — in real time. Ah, I got lost in thought... Dreaming is never a bad thing. Imagine that the "holograms" you create in your mind can be prototypes for groundbreaking inventions. Big ideas lead to even bigger holograms. While not all holograms may fit into reality, perhaps yours just might. So never stop dreaming. Never stop "hologramming" your ideas. Keep them omnipresent throughout your life. Let them bilocate to places that no one has ever been before. PS See one of the very first prototypes of molecular holograms of mouse development. --- Thank you so much for reading. Wish to learn more? Hit the 𝐅𝐨𝐥𝐥𝐨𝐰 [👥👋🏼] — you'll never miss out on the latest 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 news 🎯! Give it a like [👍🏼] or share [🕊️] the post to spread this Epi-message 💌. I'm 𝐃𝐚𝐦𝐢𝐚𝐧, & I talk about: #precisionmedicine #epigenetics #genomics #singlecell #genetics #science #health — Always be on top of your DNA!

𝐓𝐡𝐞 𝐇𝐮𝐦𝐚𝐧 𝐂𝐞𝐥𝐥 𝐀𝐭𝐥𝐚𝐬: 𝐇𝐨𝐰 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐬𝐭𝐬 𝐜𝐫𝐞𝐚𝐭𝐞𝐝 𝐭𝐡𝐞 𝐟𝐢𝐫𝐬𝐭 𝐝𝐫𝐚𝐟𝐭 𝐨𝐟 𝐚 "𝐖𝐢𝐤𝐢𝐩𝐞𝐝𝐢𝐚 𝐟𝐨𝐫 𝐜𝐞𝐥𝐥𝐬" Perhaps it's not perfect, & it may not be complete yet. Yes, it is still a draft. After all, Rome wasn't built in a day, & neither was Wikipedia or any other significant endeavour. The initiative by the global community of the Human Cell Atlas (HCA) consortium has transformed our understanding of cellular systems. This is just the beginning, laying the foundation for future breakthroughs in Science. Would you like to learn more about the human body? Perhaps you’d also like to read the papers or explore the data generated by the HCA community? You can find some really interesting resources in the comments. Enjoy the first draft of the "Wikipedia for cellular systems". --- Thank you so much for reading. Wish to learn more? Hit the 𝐅𝐨𝐥𝐥𝐨𝐰 [👥👋🏼] — you'll never miss out on the latest 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 news 🎯! Give it a like [👍🏼] or share [🕊️] the post to spread this Epi-message 💌. I'm 𝐃𝐚𝐦𝐢𝐚𝐧, & I talk about: #precisionmedicine #epigenetics #genomics #singlecell #genetics #science #health — Always be on top of your DNA!

𝐓𝐡𝐞 𝐞𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐦𝐞𝐦𝐨𝐫𝐲: 𝐖𝐡𝐨 𝐚𝐫𝐞 𝐰𝐞 𝐫𝐞𝐚𝐥𝐥𝐲? Memory is paramount. I'm not talking about the operational memory that helps you remember where you left your things yesterday. Yes, it's still crucial when you're trying to find them again. But there is another type of memory — one that relates to your origins. If you don't nurture what your ancestors passed down to you — you actually risk losing your identity. Who are you, after all? You're a human. But perhaps your are daughter/son. Some of you are parents. As you can see: there are several components that make up your identity. One thing is certain. You can't just forget your roots. Each of us has a unique journey/fate that begins with our birth & ends with our inevitable death. When we look at it on a cellular level, the concept isn't very different. Your cells can remember things just like you do. This is what makes them special. They also follow their destinies. Sometimes these trajectories are not straightforward (like our own lives). It's unimaginable that cells can retain information for thousands of years in nearly unchanged form. This is what puzzles scientists worldwide. But we still don’t know the mechanism behind this process or even, where precisely this "memory code" is stored. Only recently have scientists concluded that this cellular memory is epigenetic in nature, & that the answer to its origins lies in the epigenome (specifically, DNA methylation & the histone code). We are only beginning to understand this mesmerising phenomenon... Here is an example of a study that brings us a step closer to evolving our understanding of epigenetic cellular memory. These efforts undoubtedly help answer the question: "Who are we really?" --- Thank you so much for reading. Wish to learn more? Hit the 𝐅𝐨𝐥𝐥𝐨𝐰 [👥👋🏼] — you'll never miss out on the latest 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 news 🎯! Give it a like [👍🏼] or share [🕊️] the post to spread this Epi-message 💌. I'm 𝐃𝐚𝐦𝐢𝐚𝐧, & I talk about: #precisionmedicine #epigenetics #genomics #singlecell #genetics #science #health — Always be on top of your DNA!

𝐓𝐡𝐞 𝐧𝐨𝐧-𝐜𝐨𝐝𝐢𝐧𝐠 𝐑𝐍𝐀𝐬 𝐜𝐡𝐨𝐨𝐬𝐞 𝐰𝐡𝐞𝐫𝐞 𝐚𝐜𝐜𝐞𝐧𝐭𝐬 𝐟𝐚𝐥𝐥 𝐢𝐧 𝐚 𝐬𝐜𝐫𝐢𝐩𝐭 𝐨𝐟 𝐍𝐚𝐭𝐮𝐫𝐞 —"𝐓𝐡𝐞 𝐆𝐞𝐧𝐞𝐭𝐢𝐜 𝐀𝐥𝐩𝐡𝐚𝐛𝐞𝐭". Do you speak "Genetisch"? No worries, you don't have to! Because "Genetics" speaks for you. Did you know that the genetic letters (A, T, C & G) are irreplaceable components of "The Code of Life"? These letters make up one of the oldest alphabets we've ever known—even older than the Phoenician & Hebrew alphabets. Both seem a bit simpler, don't they? But it took humans (baby) steps to learn the ATCG alphabet—only three decades ago. That was when 𝐓𝐡𝐞 𝐇𝐮𝐦𝐚𝐧 𝐆𝐞𝐧𝐨𝐦𝐞 𝐏𝐫𝐨𝐣𝐞𝐜𝐭 kicked off. After many years, our civilization finally laid eyes on a human genetic sequence for the first time! Yet, why did it take us almost 200,000 years to learn the basics of this 𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐚𝐥𝐩𝐡𝐚𝐛𝐞𝐭? The results? Not so great. I challenge you to find someone who can spell out their genetic sequence without taking a breath. It implies that the genetic code is not a walk in the park. I'd bet you'd pick up Egyptian hieroglyphs way faster. Why? No need for special equipment like 𝐍𝐆𝐒 𝐬𝐞𝐪𝐮𝐞𝐧𝐜𝐞𝐫𝐬 or 𝐜𝐨𝐦𝐩𝐮𝐭𝐢𝐧𝐠 𝐢𝐧𝐟𝐫𝐚𝐬𝐭𝐫𝐮𝐜𝐭𝐮𝐫𝐞. No "cloud" needed — just a bit of light. And there's another layer of complexity to this alphabet. - 𝐓𝐫𝐚𝐧𝐬𝐥𝐚𝐭𝐢𝐨𝐧 process. It resembles a commonly used translator, but it goes by the name: "𝐆𝐞𝐧𝐨𝐦𝐞-𝐓𝐫𝐚𝐧𝐬𝐥𝐚𝐭𝐞." But how does it appear in reality? Translation is comparable to reading through a protein recipe (𝐦𝐑𝐍𝐀) & assembling it systematically. Imagine now a small-scale factory (𝐫𝐢𝐛𝐨𝐬𝐨𝐦𝐞) where three-letter codes (𝐜𝐨𝐝𝐨𝐧𝐬) in the recipe correspond with amino acids—the essential elements for constructing the protein. But strikingly, not all genes code for proteins. In your DNA sequence, there is a large portion that encodes RNA molecules. These can be either small or long RNA species. Now, scientists are trying to understand what they actually do. We know quite a lot, but many questions remain unanswered. One could say non-coding RNAs place emphasis on the words formed from our genetic alphabet. This way they regulate how & when genes are expressed. The recent Cell's review provides us with the knowledge scientists have about these tiny, quiet genomic guides. Enjoy the reading. Please check the comments for the link to the article. --- Thank you so much for reading. Wish to learn more? Hit the 𝐅𝐨𝐥𝐥𝐨𝐰 [👥👋🏼] — you'll never miss out on the latest 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 news 🎯! Give it a like [👍🏼] or share [🕊️] the post to spread this Epi-message 💌. I'm 𝐃𝐚𝐦𝐢𝐚𝐧, & I talk about: #precisionmedicine #epigenetics #genomics #singlecell #genetics #science #health — Always be on top of your DNA!

𝐃𝐫𝐨𝐩𝐥𝐞𝐭 𝐇𝐢-𝐂: 𝐚 𝐧𝐞𝐰 𝐭𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐲 𝐟𝐨𝐫 𝐬𝐢𝐧𝐠𝐥𝐞-𝐜𝐞𝐥𝐥 𝐜𝐡𝐫𝐨𝐦𝐚𝐭𝐢𝐧 𝐩𝐫𝐨𝐟𝐢𝐥𝐢𝐧𝐠 𝐢𝐧 𝐜𝐨𝐦𝐩𝐥𝐞𝐱 𝐭𝐢𝐬𝐬𝐮𝐞𝐬 Scientists have recently introduced Droplet Hi-C — a new epigenomic technology for scalable single-cell chromatin profiling. I already love it. Utilising commercial microfluidic devices — this method enables high-throughput analysis of chromatin architecture in heterogeneous tissues. In short, it’s perfect for analysing challenging biological material. Especially, if you want to understand what’s happening at the chromatin level. 𝐇𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭𝐬: • Droplet Hi-C can process 40,000 or more cells simultaneously, making it highly scalable for large-scale chromatin analysis. • Droplet Hi-C is more affordable than existing systems. It lowers the financial barrier for conducting high-throughput assays. • This method is well-suited for analysing heterogeneous tissues & tumour biopsies. • Droplet Hi-C requires less hands-on time, streamlining the workflow for researchers & enhancing efficiency. • The method facilitates high-throughput single-cell Hi-C assays, advancing the study of chromatin interactions at a single-cell level. Enjoy the reading! --- Thank you so much for reading. Wish to learn more? Hit the 𝐅𝐨𝐥𝐥𝐨𝐰 [👥👋🏼] — you'll never miss out on the latest 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 news 🎯! Give it a like [👍🏼] or share [🕊️] the post to spread this Epi-message 💌. I'm 𝐃𝐚𝐦𝐢𝐚𝐧, & I talk about: #precisionmedicine #epigenetics #genomics #singlecell #genetics #science #health — Always be on top of your DNA!

𝐌𝐮𝐥𝐭𝐢-𝐦𝐨𝐝𝐚𝐥 𝐬𝐢𝐧𝐠𝐥𝐞-𝐜𝐞𝐥𝐥 𝐨𝐦𝐢𝐜𝐬 𝐮𝐧𝐜𝐨𝐯𝐞𝐫𝐞𝐝 𝐧𝐞𝐰 𝐠𝐞𝐧𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐨𝐫𝐲 𝐧𝐞𝐭𝐰𝐨𝐫𝐤𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐡𝐮𝐦𝐚𝐧 𝐡𝐞𝐚𝐫𝐭 The era of relying on averaged bulk tissue data is over — examining individual cells is now essential, not optional. Whether you like it or not, single-cell tech is set to dominate the field of genomics. Single-cell omics technologies are revolutionising our understanding of gene regulation. This enables us to decode the enigmatic genetic Code of Life. Most importantly, this helps us better understand both our health & disease states. Revolution means that in the coming years, (epi)genomics research will rely solely on single-cell sequencing, coupled with other methods such as genome engineering, imaging, & more... Current technologies & their future advancements will come together to connect diverse molecular layers, creating a true reflection of the epigenetic landscape. You may feel single-cell omics is not yet in the public domain. People aren't talking about it like they do with AI. But... I assure you, we geneticists aren’t jealous. It's a niche area — not a rocket launch to Mars — but its impact is far greater than you might think. We are closer than ever to understanding the true causes of many life-threatening diseases. With humility, we observe what is happening now, developing these methods to ask even bolder questions. To drive the next breakthroughs, we must be precise, not vague. To achieve this, scientists need more tools that offer such "unmatched" precision. Single-cell research is really buzzing in the scientific community. The hype around studying individual cells in their specific context of space & time is evident. This article is just an example of early efforts where single-cell omics revealed gene regulatory networks, specifically in the human heart. A small spoiler alert: It's not a guide on how to win someone's heart, so please don't be disappointed that these networks aren't about love hints. My apologies... Enjoy the reading! 𝐇𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭𝐬: • Defined gene networks directing distinct human cardiomyocyte developmental stages • Revealed divergent cardiomyocyte lineages with distinct gene programs & functions • Uncovered key transcription factors for lineage-specific cardiomyocyte traits • Linked HSF1 loss to impaired cardiac metabolism & survival in human cells --- Thank you so much for reading. Wish to learn more? Hit the 𝐅𝐨𝐥𝐥𝐨𝐰 [👥👋🏼] — you'll never miss out on the latest 𝐄𝐩𝐢𝐠𝐞𝐧𝐞𝐭𝐢𝐜 news 🎯! Give it a like [👍🏼] or share [🕊️] the post to spread this Epi-message 💌. I'm 𝐃𝐚𝐦𝐢𝐚𝐧, & I talk about: #precisionmedicine #epigenetics #genomics #singlecell #genetics #science #health — Always be on top of your DNA!