I've been taking the supplement labeled simply "inositol powder," sometimes called myo-inositol, but not specifically the nicotinate variant, for anxiety for about 5 months. It has been the most effective anxiolytic supplement I've tried, and I'm very happy with the results. I take 3 slightly heaping teaspoonfuls a day (about 15 grams). This is consistent with the therapeutic dose that's been found effective in several lab studies. Inositol powder tastes similar to sugar and has scientifically been... rated as "half the sweetness of sugar," so it's easy to take. Unfortunately, it can cause diarrhea for many people, and I still experience this occasionally, but it's a small price to pay for relief from the terrible, near-crippling chronic anxiety I had for 8 months after hospitalization for serotonin syndrome. Prior to inositol, for anxiety I tried magnesium, bacopa, ashwaganda, methylfolate, B12, B6, L-theanine, and hydroxyzine (Vistaril, which I find pretty much worthless, even at 200 mgs), including the seroquel and lamotrigine prescription meds which I still take daily. Inositol has been the most effective supplement I've tried. I learned about it by reading a post by a psychiatrist on the Psychiatric Times website extolling inositol as for anxiety, so I tried it. Within 5 days of starting inositol, my anxiety began to fade significantly. Anxiety still emerges a bit occasionally, but is nowhere as severe as before supplementing with inositol. I keep a journal in which I record my anxiety level on a scale of 1-5, with 4 being extreme discomfort and 1 being a very mild undercurrent of anxiety. Before inositol I was at 3-4 most days. Since starting inositol, my anxiety level typically ranges from 0-2, with most days at 0-1. There is research supporting the effectiveness of inositol as an anxiolytic on the web. I'm surprised WebMD doesn't have anxiety listed in the dropdown menu under "Reason for Taking This Treatment." I use Vitacost brand. Read More Read Less