Archive of Clinical Cases

🔍 Did you know that managing simultaneous bilateral proximal femoral fractures with dissimilar anatomical patterns presents a unique surgical challenge, particularly in elderly patients? 💉 A remarkable case details the management of a 90-year-old woman with simultaneous bilateral hip fractures following a low-energy fall. The fractures involved a right extracapsular intertrochanteric neck of femur fracture and a left intracapsular subcapital neck of femur fracture—rarely seen together in such distinct anatomical regions. The patient's treatment required a two-stage surgical approach: a dynamic hip screw (DHS) for the right side, followed by a cemented hip hemiarthroplasty for the left. 🩻 This case emphasizes the complexity of treating dissimilar bilateral fractures, highlighting the need for: ✔ Thorough preoperative planning, taking into account patient comorbidities and the risk of anesthetic complications ✔ A multidisciplinary approach for surgical coordination, including orthopedic, anesthetic, and geriatric teams ✔ Close postoperative monitoring and rehabilitation due to the increased risks of complications and recovery challenges 💡 This report is an important reminder of the intricate surgical decisions required for elderly patients with complex fracture patterns. With thoughtful planning and teamwork, these challenging cases can lead to positive outcomes, as demonstrated by the patient's full recovery. 🔗 [Read the full case: https://lnkd.in/du2eykVb] #BilateralFractures #HipFractures #OrthopedicSurgery #ElderlyCare #CaseReport #MultidisciplinaryTeam #SurgicalChallenges #ClinicalInnovation #ArchiveofClinicalCases

🔍 Did you know that treating autoimmune hemolytic anemia with steroids can unintentionally reactivate tuberculosis, creating a dangerous medical paradox? 💉 A compelling case from Archive of Clinical Cases details a patient with warm autoimmune hemolytic anemia (AIHA) complicated by pulmonary tuberculosis (TB)—a rare but challenging coexistence. The cornerstone of AIHA treatment, corticosteroids, can suppress the immune system, inadvertently triggering TB reactivation. This presents a critical dilemma for clinicians: how do you control autoimmunity without fueling a life-threatening infection? 🩸 The case highlights the complex interplay between immunity, infection, and treatment strategies. Managing these conditions requires: ✔ Early and accurate diagnosis to identify TB risk before initiating immunosuppression ✔ A carefully balanced therapeutic approach, weighing the benefits of steroids against the dangers of TB progression ✔ A multidisciplinary team, including hematologists, infectious disease specialists, and pulmonologists, to tailor treatment and improve patient outcomes 💡 This report serves as an important reminder of the hidden risks in treating autoimmune diseases and the need for personalized, vigilant patient care. As medicine advances, recognizing such intricate interactions can save lives and refine clinical decision-making. 🔗 [Read the full case: https://lnkd.in/dJUYfPEf] #AutoimmuneHemolyticAnemia #Tuberculosis #CaseReport #Hematology #InfectiousDiseases #ClinicalChallenges #MedicalInnovation #PatientCare #ArchiveofClinicalCases

🔍 Did you know that Pembrolizumab, a groundbreaking immunotherapy for cancer, can trigger severe multi-organ immune-related adverse events? 💉 A fascinating case from Archive of Clinical Cases details a patient with non-small cell lung cancer (NSCLC) who developed a rare combination of autoimmune conditions: myasthenia gravis, myositis, hepatitis, and pityriasis lichenoides. The simultaneous occurrence of these conditions presented significant diagnostic and treatment challenges, highlighting the complex immune responses triggered by checkpoint inhibitors. 🔬 Multidisciplinary intervention was critical in stabilizing the patient. The case underscores the importance of personalized care, early symptom detection, and tailored immunosuppressive treatments to manage these rare but severe complications. 💡 While Pembrolizumab revolutionizes cancer care, clinicians must remain vigilant for these rare immune events, balancing therapeutic benefits with risks. This case contributes valuable insights for healthcare teams navigating the complex landscape of immunotherapy complications. 🔗 [Read the full case: https://lnkd.in/dr9buUkU] #CancerImmunotherapy #Pembrolizumab #ImmuneRelatedEvents #CaseReport #ArchiveofClinicalCases #LungCancer #MedicalInnovation #PatientCare

Dear Readers, Authors, and Collaborators, As the holiday season embraces us with its warmth and festive spirit, we take a moment to express our heartfelt gratitude for your invaluable contributions to the Archive of Clinical Cases. Your dedication to advancing clinical knowledge, sharing insightful cases, and supporting our mission is the cornerstone of our success. This Christmas, may your homes be filled with joy, your hearts with peace, and your endeavors with inspiration. As we look forward to the New Year, let us continue to collaborate, learn, and grow together, making a lasting impact in the world of medicine. Wishing you and your loved ones a holiday season full of cheer, good health, and countless blessings. Warmest regards, Mihai Danciu Editor-in-Chief (on behalf of the Editorial Board of Archive of Clinical Cases)

🔍 Did you know that a rare pregnancy complication is the breast enlargement so extreme it disrupts daily life? 🤰 Meet gestational gigantomastia (GG)—a condition where excessive breast enlargement during pregnancy leads to severe discomfort, including back pain, sleep disturbances, and difficulty with daily activities. A recent case from McGill University highlights how an innovative surgical approach, combining the Goldilocks technique with free nipple grafting, successfully treated a 29-year-old pregnant woman suffering from severe GG. 🔬 In this groundbreaking case, the patient underwent bilateral skin-sparing mastectomy and immediate reconstruction, resulting in significant functional and aesthetic improvements. The Goldilocks technique reduced the risk of complications and provided a foundation for potential future breast enhancements. 💡 While hormonal therapies have been used in managing GG, surgery is often required in severe cases, especially when complications like skin ulceration arise. This case demonstrates how modern reconstructive techniques can provide life-changing outcomes for patients experiencing this rare and challenging condition. 🔗 [Explore the full study and learn more about this innovative approach: https://lnkd.in/dEGRyhiW] #GestationalGigantomastia #BreastSurgery #GoldilocksTechnique #SurgicalInnovation #MaternalHealth #BreastReconstruction #PlasticSurgery #McGillUniversity #HealthCareAdvancements #WomenHealth #CaseReport #ArchiveofClinicalCases

🌟 Did you know that a simple drop in oxygen levels after childbirth could signal a life-threatening heart condition? 🩺 Peripartum Cardiomyopathy (PPCM) is a rare yet dangerous condition that affects some women during or shortly after pregnancy, leading to heart failure. Despite its serious nature, PPCM is often difficult to diagnose, as its symptoms can be mistaken for normal postpartum changes. 💔 A recent case highlights how a 23-year-old woman, post-C-section from a twin pregnancy, presented with oxygen desaturation—without any other classic heart failure symptoms—leading to a surprising diagnosis of PPCM. This case emphasizes the importance of considering PPCM even when symptoms don’t align with the typical presentation. 🔬 Early diagnosis and treatment are crucial for improving survival and recovery. In this case, a multidisciplinary team worked quickly to manage her condition, and after treatment, she was discharged with a normal follow-up. 🧠 PPCM remains a medical challenge, but with greater awareness, timely intervention can save lives. 🔗 [For more details on this case, click here: https://lnkd.in/diTwz8Jx ] #PPCM #PeripartumCardiomyopathy #HeartFailure #PostpartumCare #CardiovascularHealth #WomenHealth #EarlyDiagnosis #CaseReport #ClinicalMedicine #Cardiology #HeartHealth #MedicalAwareness #ArchiveofClinicalCases

🔍 Did you know that elevated procalcitonin (PCT) levels could indicate more than just an infection? ✨ Meet Medullary Thyroid Carcinoma (MTC)—a rare and aggressive neuroendocrine tumor often overlooked in daily clinical practice. In a recent case, a 38-year-old patient initially suspected of having complications from COVID-19 presented with persistently high PCT levels, despite antibiotic treatment. What followed was a diagnostic journey revealing an unexpected culprit: MTC. 🔬 A detailed workup, including neck ultrasound and calcitonin stimulation tests, confirmed the diagnosis of medullary thyroid microcarcinoma with lymph node metastases. This case highlights how multidisciplinary teamwork and vigilance in differential diagnoses can lead to life-saving interventions. 💡 While MTC often masquerades as benign, its early detection and management—especially when calcitonin and PCT levels are elevated—are crucial. Surgical resection remains the cornerstone of treatment, with targeted therapies offering hope in advanced cases. This case underscores the importance of thinking beyond infection when PCT levels remain high. Could there be other hidden malignancies waiting to be uncovered? 🤔 🔗 [Explore this fascinating case and its implications: https://lnkd.in/detRhhMi] #MedullaryThyroidCarcinoma #Procalcitonin #RareDiseases #ThyroidCancer #MultidisciplinaryCare #EarlyDiagnosis #Oncology #Endocrinology #CaseReport #ArchiveOfClinicalCases

📖 Did you know that even the most advanced imaging can miss critical clues in rare lung diseases, leaving histopathology to reveal the true story? 🤯 Step into the fascinating world of Pulmonary Langerhans Cell Histiocytosis (PLCH) – a rare and puzzling lung disease commonly linked to smoking. But what happens when it presents in an entirely unexpected way? Meet a 34-year-old man who showed signs of PLCH through high-resolution CT (HRCT), but biopsy results took an unexpected turn, revealing Non-Specific Interstitial Pneumonia (NSIP) instead! 🫣 So here’s the big question: What happens when a rare lung disease defies its typical markers and leaves imaging and pathology at a crossroads? 🤔 Could this shift in presentation change how we diagnose and treat PLCH in the future? Despite the absence of genetic mutations and the usual smoking-related pathology, this case highlights how rare diseases can sometimes behave unpredictably. The complexity of diagnosing rare lung conditions like PLCH makes it clear that collaboration, advanced tools, and ongoing research are key to unraveling these mysteries. 💡 🔬 Curious about how the future of diagnosis could look for rare lung diseases? Take a deeper dive into this case and explore the unexpected twists that make it truly unique. [Explore this rare case and its implications by clicking here: https://lnkd.in/dRFZYrNS ]🌟 #LungDisease #PLCH #RareDiseases #MedicalCaseStudy #Pulmonology #AdvancedImaging #Histopathology #HealthcareInnovation #ArchiveofClinicalCases #MedicalResearch #CaseReport #Oncology

✨ Did you know that the combination of extracorporeal membrane oxygenation (ECMO) and hematopoietic stem cell transplant (HSCT) is an emerging, yet rarely documented therapeutic strategy for managing life-threatening complications in rare genetic disorders? 🧒🏻In this extraordinary case, a 3-month-old patient with Hunter Syndrome developed recurrent diffuse alveolar hemorrhage (DAH) following HSCT. ECMO was employed as a lifesaving measure, along with unconventional techniques like endotracheal tube clamping, to address this severe complication. 🔬 While the initial response to ECMO was promising, recurrent episodes of DAH ultimately led to the patient’s decline, underscoring the complexity of balancing innovative therapies with the unpredictable course of rare diseases. 💡 What sets this case apart? It’s the first documented instance of DAH requiring ECMO in a Hunter Syndrome patient post-HSCT, offering valuable insights into the challenges and potential of these advanced therapies. 👉 Can ECMO and HSCT pave the way for new treatment paradigms in Hunter Syndrome, or do the risks outweigh the benefits? 🔗 [Read the full case report and its implications: https://lnkd.in/dVu92vtr] #HunterSyndrome #DiffuseAlveolarHemorrhage #ECMO #HSCT #RareDiseases #CriticalCareMedicine #ArchiveOfClinicalCases #MedicalBreakthroughs #CaseReport

🧬 Did you know the “new kid on the block”: Xanthogranulomatous Epithelial Tumor or XGET? ✨Meet Xanthogranulomatous Epithelial Tumor (XGET)—an incredibly rare neoplasm that blends unexpected cell types and defies easy classification. Recently documented in medical literature, XGET stands out for its unusual mix of foamy histiocytes, giant cells, and clusters of keratin-positive cells. This case focuses on a 66-year-old woman who presented with a distinctive 5 cm mass in her thigh. Surprisingly, this wasn’t just another soft tissue lesion; it was a new, poorly understood tumor with unique histologic features. 💡 After thorough imaging, an ultrasound-guided biopsy revealed the tumor’s bizarre cellular makeup, but left the team with as many questions as answers. Surgical resection seemed like the only option, and a post-op analysis confirmed XGET—yet a genetic fusion commonly linked to it, HMGA2-NCOR2, was mysteriously absent. 🔬 What could explain this anomaly? Are XGET and other rare tumors like it evolving in ways we have yet to understand? This case shows the power of interdisciplinary teamwork and raises the bar for future research on emerging tumors with uncertain biology. In a field where every new tumor profile reshapes diagnostic pathways, could this be one of many new entities waiting to be discovered?🤔 🔗 [Explore this rare case and its implications: https://lnkd.in/dJ8ab2FX ] #XanthogranulomatousEpithelialTumor #RareTumors #SoftTissueOncology #CancerMysteries #CaseReport #ArchiveofClinicalCases #InterdisciplinaryResearch #MedicalBreakthroughs #Oncology