Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy
BE Porter, C Jacobson - Epilepsy & Behavior, 2013 - Elsevier
Severe childhood epilepsies are characterized by frequent seizures, neurodevelopmental
delays, and impaired quality of life. In these treatment-resistant epilepsies, families often seek …
delays, and impaired quality of life. In these treatment-resistant epilepsies, families often seek …
The perineuronal net component of the extracellular matrix in plasticity and epilepsy
PA McRae, BE Porter - Neurochemistry international, 2012 - Elsevier
During development the extracellular matrix (ECM) of the central nervous system (CNS)
facilitates proliferation, migration, and synaptogenesis. In the mature nervous system due to …
facilitates proliferation, migration, and synaptogenesis. In the mature nervous system due to …
Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy
…, WK Doyle, GA Grant, BE Porter… - Annals of …, 2018 - Wiley Online Library
Objective Somatic variants are a recognized cause of epilepsy‐associated focal malformations
of cortical development (MCD). We hypothesized that somatic variants may underlie a …
of cortical development (MCD). We hypothesized that somatic variants may underlie a …
Somatic variants in diverse genes leads to a spectrum of focal cortical malformations
…, HGW Lidov, H Vogel, GA Grant, BE Porter… - Brain, 2022 - academic.oup.com
Post-zygotically acquired genetic variants, or somatic variants, that arise during cortical
development have emerged as important causes of focal epilepsies, particularly those due to …
development have emerged as important causes of focal epilepsies, particularly those due to …
Perineuronal net degradation in epilepsy
…, E Baranov, S Rogers, L Wandrey, BE Porter - …, 2015 - Wiley Online Library
Objective We previously reported loss of perineuronal net ( PN ) immunohistochemical staining
around parvalbumin‐positive interneurons in the hippocampus of rats after an episode of …
around parvalbumin‐positive interneurons in the hippocampus of rats after an episode of …
Early treatment with vigabatrin does not decrease focal seizures or improve cognition in tuberous sclerosis complex: the PREVeNT trial
EM Bebin, JM Peters, BE Porter… - Annals of …, 2024 - Wiley Online Library
Objective This study was undertaken to test the hypothesis that early vigabatrin treatment in
tuberous sclerosis complex (TSC) infants improves neurocognitive outcome at 24 months of …
tuberous sclerosis complex (TSC) infants improves neurocognitive outcome at 24 months of …
MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways
…, AN Lamb, RA Schultz, E Berry-Kravis, BE Porter… - neurogenetics, 2013 - Springer
MEF2C haploinsufficiency syndrome is an emerging neurodevelopmental disorder associated
with intellectual disability, autistic features, epilepsy, and abnormal movements. We report …
with intellectual disability, autistic features, epilepsy, and abnormal movements. We report …
Interictal EEG spikes identify the region of electrographic seizure onset in some, but not all, pediatric epilepsy patients
…, C Wusthoff, PB Storm Jr, B Litt, BE Porter - …, 2010 - Wiley Online Library
Purpose: The role of sharps and spikes, interictal epileptiform discharges (IEDs), in guiding
epilepsy surgery in children remains controversial, particularly with intracranial …
epilepsy surgery in children remains controversial, particularly with intracranial …
Persistent decrease in multiple components of the perineuronal net following status epilepticus
…, E Baranov, SL Rogers, BE Porter - European Journal of …, 2012 - Wiley Online Library
In the rodent model of temporal lobe epilepsy, there is extensive synaptic reorganization
within the hippocampus following a single prolonged seizure event, after which animals …
within the hippocampus following a single prolonged seizure event, after which animals …
Changes in microRNA expression in the whole hippocampus and hippocampal synaptoneurosome fraction following pilocarpine induced status epilepticus
RM Risbud, BE Porter - PloS one, 2013 - journals.plos.org
MicroRNAs regulate protein synthesis by binding non-translated regions of mRNAs and
suppressing translation and/or increasing mRNA degradation. MicroRNAs play an important …
suppressing translation and/or increasing mRNA degradation. MicroRNAs play an important …