Simple Summary The value of animal research has been increasingly debated, owing to
high failure rates in drug development. A potential contributor to this situation is the lack of …

Introduction Poor translation of efficacy data derived from animal models can lead to clinical
trials unlikely to benefit patients–or even put them at risk–and is a potential contributor to …

Clinical trial failures (>99%) in Alzheimer's disease are in stark contrast to positive efficacy
data in animals. We evaluated the correlation between animal and clinical efficacy outcomes (…

National and international laws and regulations exist to protect animals used for scientific
purposes in translational and applied research, which includes drug development. However, …

Immunoglobulin E (IgE)-mediated allergy against cow’s milk protein fractions such as whey
is one of the most common food-related allergic disorders of early childhood. Histone …

The first author’s initials appear incorrectly in the citation. The correct citation is: Ferreira GS,
Veening-Griffioen DH, Boon WPC, Moors EHM, Gispen-de Wied CC, Schellekens H, et al.(…

Previous qualitative research has suggested there are only minor differences between the
db/db mouse and the Zucker Diabetic Fatty (ZDF) rat, both animal models of type 2 diabetes. …

The primary purpose of this study was to assess the translatability of preclinical to early
clinical tolerable and pharmacologically active dose ranges for central nervous system (CNS) …

Investments in drug development for Alzheimer’s disease (AD) have not led to the availability
of a treatment to cure or halt the progression of the disease. This study aimed to provide …