Previous studies have led to the proposal that patients with Alzheimer's disease (AD) may
have disturbed functional connectivity between different brain regions. Furthermore, recent …

Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1
is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 …

A superhydrophobic steel surface was prepared through a facile method: combining hydrogen
peroxide and an acid (hydrochloric acid or nitric acid) to obtain hierarchical structures on …

We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within
19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G …

Object detection, scene graph generation and region captioning, which are three scene
understanding tasks at different semantic levels, are tied together: scene graphs are generated …

The pyroptosis execution protein GSDMD is cleaved by inflammasome-activated caspase-1
and LPS-activated caspase-11/4/5. The cleavage unmasks the pore-forming domain from …

Pyroptosis is a form of cell death that is critical for immunity. It can be induced by the
canonical caspase-1 inflammasomes or by activation of caspase-4, -5 and -11 by cytosolic …

The BCL-2 family of proteins consists of both antagonists (eg, BCL-2) and agonists (eg, BAX)
that regulate apoptosis and compete through dimerization. The BH1 and BH2 domains of …

Lungfishes are the closest extant relatives of tetrapods and preserve ancestral traits linked
with the water-to-land transition. However, their huge genome sizes have hindered …

Inflammatory caspases cleave the gasdermin D (GSDMD) protein to trigger pyroptosis, a
lytic form of cell death that is crucial for immune defences and diseases. GSDMD contains a …