Personalized medicine: time for one-person trials

NJ Schork - Nature, 2015 - nature.com
NJ Schork
Nature, 2015nature.com
… Classical clinical trials harvest a handful of measurements from thousands of people.
Precision medicine requires different ways of testing interventions. Researchers need to
probe the myriad factors — genetic and environmental, among others — that shape a
person's response to a particular treatment. … Key to making precision medicine
mainstream is the ongoing shift in the relationship between patients and physicians. A
major advantage of the N-of-1 approach over classical …
Precision medicine requires a different type of clinical trial that focuses on individual, not average, responses to therapy, says Nicholas J. Schork.
nature.com
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