Systemic lupus erythematosus (SLE) is a genetically predisposed, female-predominant
disease, characterized by multiple organ damage, that in its most severe forms can be life-…

T-helper 17 (Th17) cells represent a subpopulation of CD4+ T lymphocytes that play an essential
role in defense against pathogens. Th17 cells are distinguished from Th1 and Th2 cells …

Full article: One-year effectiveness, retention rate, and safety of secukinumab in ankylosing
spondylitis and psoriatic arthritis: a real-life multicenter study Skip to Main Content Taylor and …

Background and Objectives: Interleukin-17 (IL-17) is a cytokine family consisting of six
members and five specific receptors. IL-17A was the first member to be identified in 1993. Since …

Here, we developed an unbiased, functional target-discovery platform to identify immunogenic
proteins from primary non-small cell lung cancer (NSCLC) cells that had been induced to …

Background: Tubulointerstitial nephritis and uveitis syndrome (TINU) is a rare disorder
typically characterized by sudden-onset non-granulomatous anterior uveitis associated with …

Background: Tofacitinib (TOFA) was the first Janus kinase inhibitor (JAKi) to be approved for
the treatment of rheumatoid arthritis (RA). However, data on the retention rate of TOFA …

Giant cell arteritis (GCA) is a noninfectious granulomatous vasculitis of unknown etiology
affecting individuals older than 50 years. Two forms of GCA have been identified: a cranial form …

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease involving the spine, peripheral
joints, and entheses. This condition causes stiffness, pain, and significant limitation of …

The mechanisms whereby autoreactive T cells escape peripheral tolerance establishing thus
autoimmune diseases in humans remain an unresolved question. Here, we demonstrate …