Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

…, Q Qiao, AV Hauenstein, Z Wu, G Núñez, Y Mao, H Wu - Nature, 2019 - nature.com
The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid crystals,
amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the assembly …

Reserve constrained dynamic economic dispatch with valve-point effect: A two-stage mixed integer linear programming approach

Z Wu, J Ding, QH Wu, Z Jing… - CSEE Journal of Power …, 2017 - ieeexplore.ieee.org
This paper proposes a deterministic two-stage mixed integer linear programming (TSMILP)
approach to solve the reserve constrained dynamic economic dispatch (DED) problem …

USP14-regulated allostery of the human proteasome by time-resolved cryo-EM

S Zhang, S Zou, D Yin, L Zhao, D Finley, Z Wu, Y Mao - Nature, 2022 - nature.com
Proteasomal degradation of ubiquitylated proteins is tightly regulated at multiple levels 1 , 2
– 3 . A primary regulatory checkpoint is the removal of ubiquitin chains from substrates by the …

Visualization of ligand-bound ectodomain assembly in the full-length human IGF-1 receptor by cryo-EM single-particle analysis

…, J Sun, Y Wu, J Gong, X Li, L Liu, S Liu, J Liu, Y Wu… - Structure, 2020 - cell.com
Tyrosine kinase receptor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor
(IR) bind to hormones, such as insulin, IGF-1, and IGF-2, and transduces the signals across …

Data-Based Optimal Microgrid Management for Energy Trading With Integral Q-Learning Scheme

Y Lv, Z Wu, X Zhao - IEEE Internet of Things Journal, 2023 - ieeexplore.ieee.org
This article proposes an integral ${Q}$ -learning scheme to study the optimum management
strategy of the battery for energy trading in the microgrid. The obtained optimal strategies …

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

Y Dong, S Zhang, Z Wu, X Li, WL Wang, Y Zhu… - Nature, 2019 - nature.com
The proteasome is an ATP-dependent, 2.5-megadalton molecular machine that is
responsible for selective protein degradation in eukaryotic cells. Here we present cryo-electron …

Characterization of volatile components of microwave dried perilla leaves using GC–MS and E-nose

G Jin, Z Zhu, Z Wu, F Wang, J Li, V Raghavan, B Li… - Food Bioscience, 2023 - Elsevier
Different pretreatments followed by the drying process could affect the volatile compounds
of dried perilla leaves. This study investigated the discrepancies in the volatile profiles of …

APPFNet: Adaptive point-pixel fusion network for 3D semantic segmentation with neighbor feature aggregation

Z Wu, Y Zhang, R Lan, S Qiu, SL Ran, Y Liu - Expert Systems with …, 2024 - Elsevier
3D semantic segmentation is significant for scene understanding in various domains, such
as autonomous driving, mapping, and robotics. Existing research often enhances prediction …

Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex

X Han, D Zhang, L Hong, D Yu, Z Wu, T Yang… - Nature …, 2023 - nature.com
Biological processes are typically actuated by dynamic multi-subunit molecular complexes.
However, interactions between subunits, which govern the functions of these complexes, are …

Visualizing conformational space of functional biomolecular complexes by deep manifold learning

Z Wu, E Chen, S Zhang, Y Ma, Y Mao - International Journal of Molecular …, 2022 - mdpi.com
The cellular functions are executed by biological macromolecular complexes in nonequilibrium
dynamic processes, which exhibit a vast diversity of conformational states. Solving the …