𝗖𝗢𝗠𝗣𝗥𝗘𝗛𝗘𝗡𝗦𝗜𝗩𝗘 𝗚𝗨𝗜𝗗𝗘 𝗧𝗢 𝗡𝗦𝗔𝗜𝗗𝘀
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are a class of medications commonly used to reduce inflammation, alleviate pain, and lower fever. They work by inhibiting enzymes involved in the inflammatory process.
Mechanism of Action
🔴NSAIDs primarily inhibit the cyclooxygenase (COX) enzymes:
1. COX-1: Found in most tissues and involved in maintaining normal physiological functions, such as protecting the stomach lining, maintaining kidney function, and supporting platelet aggregation.
2. COX-2: Induced during inflammation and involved in pain and swelling.
🔴By inhibiting these enzymes, NSAIDs reduce the production of prostaglandins, which are mediators of pain, fever, and inflammation.
Common Types of NSAIDs
1. Non-selective NSAIDs (inhibit COX-1 and COX-2):
🔸Ibuprofen
🔸Naproxen
🔸Aspirin
🔸Diclofenac
🔸Indomethacin
2. COX-2 selective inhibitors (coxibs):
🔸Celecoxib
🔸Etoricoxib
3. Partially selective NSAIDs:
🔸Meloxicam
🔸Nabumetone
Uses of NSAIDs
🔵 Pain relief: Headaches, dental pain, muscle pain, and menstrual cramps.
🔵 Inflammation: Arthritis (rheumatoid arthritis, osteoarthritis), tendinitis, and bursitis.
🔵 Fever reduction: Especially in conditions like the flu.
🔵 Cardiovascular protection: Low-dose aspirin is used to prevent blood clots in individuals at risk of heart attack or stroke.
Benefits
🟣 Effective in treating mild to moderate pain.
🟣 Available in both over-the-counter (OTC) and prescription forms.
🟣 Wide range of formulations (tablets, capsules, creams, injections).
Adverse Effects
1. Gastrointestinal (GI):
- Gastritis, ulcers, bleeding, and perforation.
- Increased risk with long-term use and in individuals with a history of GI issues.
2. Cardiovascular:
- COX-2 inhibitors, in particular, may increase the risk of heart attack and stroke.
- Non-selective NSAIDs (except aspirin) may also have cardiovascular risks.
3. Renal:
- Reduced kidney function, particularly in dehydrated patients or those with pre-existing kidney disease.
4. Hepatic:
- Rare cases of liver toxicity, especially with prolonged use.
5. Others:
- Allergic reactions (rash, anaphylaxis).
- Exacerbation of asthma in sensitive individuals.
Precautions
🚨Patients with a history of ulcers, cardiovascular disease, or kidney disease.
🚨Drug Interactions:
- Warfarin or other anticoagulants (increased bleeding risk).
- ACE inhibitors and diuretics (may reduce renal function).
- Methotrexate and lithium (risk of toxicity).
Pict credit
https://lnkd.in/g7jmgSgw