Metrion Biosciences is a specialist preclinical drug discovery CRO - your trusted partner for ion channel screening, cardiac safety screening and neuroscience assays. We provide our customers with a range of in vitro screening services, including cardiac safety (GLP hERG, CiPA panel of human cardiac ion channels) and neurotoxicology testing and phenotypic assays on a fee-for-service or collaboration basis. We pride ourselves on being able to provide a flexible and cost effective service with an unparalleled level of expertise. Collectively, we have 250 years experience managing ion channel research programmes.
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Receive the latest ion channel, cardiac safety and neuroscience news from Metrion. The newsletter is not posted online, it’s 𝐨𝐧𝐥𝐲 𝐬𝐞𝐧𝐭 𝐭𝐨 𝐬𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞𝐫𝐬, so 𝐬𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝐭𝐨𝐝𝐚𝐲 to receive the latest 𝐩𝐫𝐞𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐝𝐫𝐮𝐠 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬, news, upcoming events, webinars, research findings, publications and more. https://hubs.la/Q02_zb9S0 #drugdiscovery #ionchannels #cardiacsafety #cardiacrisk #neuroscience #cns #preclinicalresearch
Successfully detect differences between compounds with low, medium and high proarrhythmic risk profiles, by evaluating the effect of compounds on action potentials recorded from hiPSC-derived cardiomyocytes using conventional manual patch-clamp methodology. https://hubs.la/Q02VsczX0 #drugdiscovery #CRO #Screening #IonChannels
Receive the latest ion channel, cardiac safety and neuroscience news from Metrion. The newsletter is not posted online, it’s 𝐨𝐧𝐥𝐲 𝐬𝐞𝐧𝐭 𝐭𝐨 𝐬𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞𝐫𝐬, so 𝐬𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝐭𝐨𝐝𝐚𝐲 to receive the latest 𝐩𝐫𝐞𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐝𝐫𝐮𝐠 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬, news, upcoming events, webinars, research findings, publications and more. https://hubs.la/Q02_zb9S0 #drugdiscovery #ionchannels #cardiacsafety #cardiacrisk #neuroscience #cns #preclinicalresearch
Another delighted customer recently shared their experience with Metrion, praising the exceptional quality of our manual electrophysiology testing. They highlighted how our scientists provided fantastic, reproducible data - even without prior information about the compounds. https://hubs.la/Q02_hFc-0 Our meticulous approach, from state-dependent blocker identification to careful handling of sample solubilization and storage, showcases the precision and expertise that set us apart. This is just one of many testimonials from satisfied clients who trust Metrion for high-quality, reliable results. 𝐂𝐡𝐨𝐨𝐬𝐞 𝐌𝐞𝐭𝐫𝐢𝐨𝐧 𝐚𝐬 𝐲𝐨𝐮𝐫 𝐭𝐫𝐮𝐬𝐭𝐞𝐝 𝐂𝐑𝐎 𝐩𝐚𝐫𝐭𝐧𝐞𝐫 𝐚𝐧𝐝 𝐞𝐱𝐩𝐞𝐫𝐢𝐞𝐧𝐜𝐞 𝐭𝐡𝐞 𝐝𝐢𝐟𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐟𝐨𝐫 𝐲𝐨𝐮𝐫𝐬𝐞𝐥𝐟 - 𝐜𝐨𝐧𝐭𝐚𝐜𝐭 𝐮𝐬 𝐭𝐨𝐝𝐚𝐲 𝐭𝐨 𝐥𝐞𝐚𝐫𝐧 𝐡𝐨𝐰 𝐰𝐞 𝐜𝐚𝐧 𝐬𝐮𝐩𝐩𝐨𝐫𝐭 𝐲𝐨𝐮𝐫 𝐩𝐫𝐞𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐝𝐫𝐮𝐠 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 𝐩𝐫𝐨𝐣𝐞𝐜𝐭𝐬: https://hubs.la/Q02_hD-20 #CRO #DrugDiscovery #Electrophysiology #PreclinicalResearch #IonChannels
𝐑𝐞𝐥𝐢𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐢𝐧𝐭𝐞𝐠𝐫𝐢𝐭𝐲 𝐨𝐟 𝐭𝐡𝐞 𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐮𝐧𝐝𝐞𝐫𝐥𝐲𝐢𝐧𝐠 𝐜𝐚𝐫𝐝𝐢𝐚𝐜 𝐬𝐚𝐟𝐞𝐭𝐲 𝐬𝐜𝐫𝐞𝐞𝐧𝐢𝐧𝐠 𝐬𝐞𝐫𝐯𝐢𝐜𝐞𝐬 𝐫𝐞𝐢𝐧𝐟𝐨𝐫𝐜𝐞𝐝 𝐛𝐲 𝐫𝐞𝐜𝐨𝐠𝐧𝐢𝐭𝐢𝐨𝐧 𝐨𝐟 𝐭𝐰𝐨 𝐬𝐢𝐠𝐧𝐢𝐟𝐢𝐜𝐚𝐧𝐭 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 Earlier this year we were honoured that two publications we co-authored were recognised by the Safety Pharmacology Society for their contribution to drug discovery and safety pharmacology research. 𝐌𝐎𝐒𝐓 𝐈𝐌𝐏𝐀𝐂𝐓𝐅𝐔𝐋 𝐏𝐔𝐁𝐋𝐈𝐂𝐀𝐓𝐈𝐎𝐍 𝐎𝐅 𝐓𝐇𝐄 𝐘𝐄𝐀𝐑 𝐓𝐡𝐞 S𝐭𝐚𝐭𝐞 𝐨𝐟 𝐭𝐡𝐞 A𝐫𝐭 𝐢𝐧 S𝐞𝐜𝐨𝐧𝐝𝐚𝐫𝐲 P𝐡𝐚𝐫𝐦𝐚𝐜𝐨𝐥𝐨𝐠𝐲 𝐚𝐧𝐝 𝐢𝐭𝐬 I𝐦𝐩𝐚𝐜𝐭 𝐨𝐧 𝐭𝐡𝐞 S𝐚𝐟𝐞𝐭𝐲 𝐨𝐟 N𝐞𝐰 M𝐞𝐝𝐢𝐜𝐢𝐧𝐞𝐬 Brennan, R.J., Jenkinson, S., Brown, A. 𝘦𝘵 𝘢𝘭. 𝘕𝘢𝘵 𝘙𝘦𝘷 𝘋𝘳𝘶𝘨 𝘋𝘪𝘴𝘤𝘰𝘷 23, 525–545 (2024). https://hubs.la/Q02-Bxch0 𝐓𝐄𝐂𝐇𝐍𝐎𝐋𝐎𝐆𝐘 𝐈𝐍𝐍𝐎𝐕𝐀𝐓𝐈𝐎𝐍 𝐏𝐔𝐁𝐋𝐈𝐂𝐀𝐓𝐈𝐎𝐍 𝐀𝐖𝐀𝐑𝐃 𝐓𝐢𝐦𝐞 𝐈𝐬 𝐚 𝐂𝐫𝐢𝐭𝐢𝐜𝐚𝐥 𝐅𝐚𝐜𝐭𝐨𝐫 w𝐡𝐞𝐧 𝐄𝐯𝐚𝐥𝐮𝐚𝐭𝐢𝐧𝐠 𝐎𝐥𝐢𝐠𝐨𝐧𝐮𝐜𝐥𝐞𝐨𝐭𝐢𝐝𝐞 𝐓𝐡𝐞𝐫𝐚𝐩𝐞𝐮𝐭𝐢𝐜𝐬 𝐢𝐧 𝐇𝐮𝐦𝐚𝐧 𝐄𝐭𝐡𝐞𝐫-𝐚-𝐆𝐨-𝐆𝐨-𝐑𝐞𝐥𝐚𝐭𝐞𝐝 𝐆𝐞𝐧𝐞 𝐀𝐬𝐬𝐚𝐲𝐬 Yusheng Qu, Robert Kirby, Richard Davies, Ayesha Jinat, Stefano Stabilini, Bin Wu, Longchuan Yu, BaoXi Gao, and Hugo M. Vargas, 𝘕𝘶𝘤𝘭𝘦𝘪𝘤 𝘈𝘤𝘪𝘥 𝘛𝘩𝘦𝘳𝘢𝘱𝘦𝘶𝘵𝘪𝘤𝘴 2023 33:2, 132-140. https://hubs.la/Q02-BgX_0 We’re thrilled to contribute to meaningful advancements in safety pharmacology and drug discovery. Thank you to the co-authors, and the Safety Pharmacology Society. #DrugDiscovery #CardiacSafety #Pharmacology #CardiacSafety #CardiacRisk
🌟 Season’s Greetings from Metrion! 🌟 As we reflect on the year, we are grateful to our valued customers, followers, partners, suppliers and colleagues for their continued support. Looking forwards to 2025, we will continue to listening to, and understand, the unique challenges and objectives of our customers to deliver tailored solutions that accelerate their drug discovery programmes and help them achieve their goals. Wishing you a joyful holiday season filled with warmth and cheer, and a prosperous New Year ahead. #SeasonGreetings #ThankYou #DrugDiscovery
HTS of vast numbers of compounds is pivotal to the drug discovery process. It is often an expensive, timely process which can return false positive results. What sets us apart is our specific high-throughput screening knowledge and experience across multiple ion channel targets. Our HTS assays are cost-efficient and timely. They support hit identification, hit-to-lead, lead optimisation and selectivity profiling. https://hubs.la/Q02Vs8Hk0 #drugdiscovery #CRO #IonChannels #Screening #highthroughputscreening
Dive into a wealth of resources designed to empower preclinical drug discovery researchers. Metrion’s Knowledge Library offers: ✔️ Insights into 📈 ion channel screening, ❤️ cardiac safety screening and 🧠 neuronal assays ✔️ In-depth articles, white papers, and more Whether you’re tackling challenges in neuroscience, pain research, or preclinical safety, our library provides the tools and knowledge to keep you ahead of the curve. Start exploring today: https://hubs.la/Q02ZYkgJ0 #DrugDiscovery #ResearchResources #Innovation #KnowledgeLibrary #IonChannels
𝐀𝐬𝐬𝐚𝐲𝐬 𝐝𝐞𝐬𝐢𝐠𝐧𝐞𝐝 𝐭𝐨 𝐡𝐞𝐥𝐩 𝐛𝐫𝐢𝐝𝐠𝐞 𝐭𝐡𝐞 𝐭𝐫𝐚𝐧𝐬𝐥𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐠𝐚𝐩 𝐛𝐞𝐭𝐰𝐞𝐞𝐧 𝒊𝒏 𝒗𝒊𝒕𝒓𝒐 𝐚𝐬𝐬𝐚𝐲𝐬 𝐚𝐧𝐝 𝒊𝒏 𝒗𝒊𝒗𝒐 𝐚𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 Metrion has extensive experience in developing screening assays against specific endogenous ion channels expressed within native neurons and glial cells to provide further compound validation. Assays can be designed specifically for your needs to explore the mechanism of action of compounds, so talk to us about your exact requirements: https://hubs.la/Q02YvxZh0 #drugdiscovery #neuroscience #CNS #ionchannels #microglia
Dr Siân Leech-Mills, Metrion's Laboratory and Safety Manger, recently attended the Institute of Safety in Technology and Research (ISTR) autumn symposium titled “50 Years of HASAWA: What's That Ever Done for Me?”. When Siân began her journey with Metrion Biosciences in 2022, one of the key attractions was the company’s commitment to its core values: excellence, respect, leadership, integrity, and teamwork. Over the past two years, she has been fortunate to play a pivotal role in advancing health and safety (H&S) within the company. With enthusiastic engagement from staff, Siân has cultivated a robust H&S culture, ensuring we continuously prioritize the health, safety, and well-being of everyone at Metrion. The company has also demonstrated unwavering support by funding internal and external training programs in areas such as: Read more: https://hubs.la/Q02ZjdVF0 #healthandsafety #wellbeing