NANOARC

The premature release of a drug has implications on the treatment of systemic and intracellular infections. #Nanoparticles are retained for much longer periods than conventional therapeutics in the body and this retainment enables a slow and sustained release of therapeutic agents. This is important because under conditions of controlled and sustained release, the goal is to ensure, that the drug concentration is maintained within the therapeutic window, thereby also decreasing the possibility of #drugresistance. These characteristics of nanoparticles are relevant in antiviral therapy in which the high dose of a drug is needed and the drugs are often very expensive. Usage of nanoparticulate carriers can reduce the frequency of the #drug intake as well as treatment timeframes, thus enhancing the effectiveness of an approved #therapeutic drug and overcome its limitations, such as low bioavailability. SOME DESIGN FACTORS Nanoparticle uptake is an important consideration in the design of nano-therapeutics, because this will have a direct influence on the therapeutic load, and hence the appropriate dose, entering the cells. Subsequent #biodegradation of the nanoparticles is critical determining the sustained release of a drug and subsequent biodistribution profiles. If biodegradation does not occur, the nanoparticle must eventually exit the cell and be excreted from the body. If nanoparticles are too large to undergo renal clearance, they may accumulate in the body. Smaller particles however (< 5 nm), can be excreted in urine. It is expected that the usage of quantum materials (typically < 20 nm in diameter) with high surface area in antiviral therapeutic processes will have positive effects in the treatment of #infectiousdiseases. These nanoparticles could potentially improve the efficacy of e.g #cancer , #diabetes, #antiviral and related drugs, to reduce the adverse side effects of such drugs on the body. OUR OFFER Therapeutic targeting of pathogens using surface-modified appropriately scaled nanoparticles is a strategy, that permits drug delivery at the organ or even cellular level. We specialise in the development and manufacture of high surface area, sub 20 nm particles. We offer them as ligand-free #nanopowder, for controlled dosage within therapeutic drugs. In the absence of ligands, there is ample surface area on the nanoparticles for the addition of the necessary amount of therapeutic molecules. The flexibility in surface functionalisation implies the nanoparticle charge can be modified to facilitate cellular uptake, when dispersed in the appropriate biocompatible medium of choice. Coupled with the advantages of slow and sustained drug release, in order to make the drug(s) more #bioavailable, there is a potential in lowering the likelihood of adverse side effects. from high drug doses. More at https://lnkd.in/esE6VFe7 #nanotechnology #drugdelivery #drugdevelopment #pharmaceuticals #biotech #biomedicine

Reducing the dose of #ZnO to address environmental concerns within the rubber industry while simultaneously increasing rubber strength, is what NANOARC's Quanπyre Division resolves, with quantum-phase #nanotechnology #Quantum effects in nanomaterials occur at grain sizes well below 20 nanometers (nm). These effects significantly enhance the performance of a material, distinguishing it significantly, from the same material, at larger grain size ( i.e. > 20 nm). Some examples entail: * increased #catalytic activity * reduced reaction temperature * enhanced #antipathogenic activity in both illuminated and dark operation conditions * more robust mechanical properties * enhanced #UV , heat and #corrosionresistance * high performance at less volume, for #lightweighting. Quanπyre - What's Different? Conventional ZnO used in the rubber industry, has a very low surface area ranging from 4–6 m2/g. This means the surface is relatively inert, hence requiring a high loading in rubber compounds, to achieve its functional goals. To elevate performance and reduce ZnO loading in rubber compounds, high surface area ZnO, prepared without ligands, are essential. The higher the surface area, the more exposed the Zn ions are for effective vulcanisation & the lower the dose necessary for rubber compounding. Conventional #nanomaterial synthesis processes however use ligands, which acts as a surface barrier, limiting access to the active #Zinc (Zn) ions. Quanπyre are quantum-grade ligand-free #nanomaterials we provide in powder form, for the enhancement of #rubber. Our Quanπyre I and Quanπyre II systems are Zn-based, have a much higher surface area and are manufactured without ligands or capping molecules, hence providing unobstructed access to the active Zn ions. Here is how we rank in specific surface area: Red Seal ZnO - 4000 to 6000 m2/kg Quanπyre I    - 41530 m2/kg Quanπyre II - 63520 m2/kg Our zinc-based Quanπyre I and Quanπyre II quantum material systems have 10 - 15x more surface area than the commonly used Red Seal ZnO and deliver substantial performance enhancement, at doses below 1.7 pphr, in e.g. aircraft #tyre applications (see website for details). For applications with lower technical requirements, the dose can be reduced further. The reduced dosage with Quanπyre provide : * increased durability against mechanical wear, shear forces and * resistance against corrosive agents for extensive service lifetime * reduced weight for fuel savings * reduced zinc-based #environmentalpollution All #Quanπyre #nanoadditives are provided in nanopowder form, for flexible dosage. They are manufactured without ligands or capping molecules, hence providing unobstructed access to the active Zinc ions. Quanπyre can be purchased exclusively on our website at https://lnkd.in/eF72dvV2 #materialengineering #advancedmaterials #rubberindustry #rubber #polymers #nanochemistry #smartmaterials #materialdesign #tyres #automotiveindustry #aerospace #vulcanization

#Nanotechnology is a deep science and a gift of #nature. However, it is a field as complex as it is counterintuitive. It requires a multi-disciplinary set of smart and common sense skills. It demands a detail-oriented drive and versatility of experience in a broad range of technological sectors, in order to be able to properly navigate its ever-advancing nature, the eccentricity of #nanomaterials, what they are, how they work, which ones to use and which to best avoid. With over 2 decades of experience in the #nanotechnological domain coupled with 10+ years in the #business thereof, NANOARC is well endowed with both the skill and experience to serve as your guiding compass. Be it for #investment guidance, #industry or #academia, we narrow down the bulk of information and sort it into the necessary fine details that enable you achieve an effective and comprehensive outcome. The Asset, In Detail. As a first measure, we shorten your learning curve. This helps you connect the dots necessary to resolve diverse, complex and sometimes seemingly unrelated issues with a more coherent and smarter approach. We identify the hidden gems in your existing arsenal to help design develop and deliver the complementary nano-systems required, to yield competitive results that are only made viable with years of advanced artistry honed, in the singular nature of nanotechnology. Learn more, explore and book a consultancy online at https://lnkd.in/eAD4_RUE #consultancyservices #strategicthinking #materialengineering #productdevelopment #businessconsulting #science #advisoryservices

Quantum materials (<< 20 nm size) are a niche class of #nanomaterials, that exhibit distinct properties from the same material at larger (nano)particle size e.g. elevated anti-fouling & resistance radiation, #chemical #corrosion, #oxidation resistance without #alloying. Quantum materials attenuate nuclear #radition at significantly higher capacity. Dense surface packing is paramount to achieve ultra-thin, transparent coatings, for #nuclear protection coupled with visibility. It's understood that : - If the underlying layer you're trying to protect has more reactivity than the top layer, corrosion proceeds faster. - If the top layer isn't dense enough, corrosion molecules ( < 1 nm) easily penetrate - #Sintering large particles creates a layer that is neither dense nor sufficiently protective. Quantum Nanopowders: - have a lower melting point and can sinter easier in shorter timeframes - form a significantly dense & almost impenetrable thin layers - are effectively reactive, offering durable protection. - adhere better to surfaces & improve layer bonding An Absence of ligands during prevents contamination and preserves functionality. Showcase - #Copper Oxide (CuO):   Sub 10nm nanopowders are essention for cold #sintering because : Bulk Cu melts at 1085C 9 nm Cu melts at ~ 1015.85 C 2 nm Cu melts at ~ 689.85 C The reduced melting point is not the sole benefit. Cu goes from being ductile to a super hard material at sizes < 5 nm - a quantum effect. NANOARC offers Quantum Nanopowders as its core expertise. With over a decade in business, the company remains singular in its ability to design & manufacture Quantum Nanopowders, at industrial scale. Some Quantum materials become more corrosion-resistant than their bulk counterparts, even resisting oxidation, at critical size & crystal structure. This paves the way for material versatility, beyond conventional ones. Why? Iridium, the most corrosion-resistant metal is hard, brittle & difficult to melt. However, the melting point of quantum nanoparticles is variable. Features hard to explore in the bulk ( > 20 nm particle size) can be tapped into quantum nanopowder-based ultra-thin, dense & lightweight coating layers. Our #Quantum #Nanopowders are of variable chemistry, for #corrosionprotection & nanofunctional applications. Systems of this nature enable ultrathin, lightweight yet densely sealed coating layers. They are attractive for remote sourcing, low-frequency maintenance procedures, fuel saving, #automotive & #aerospace applications. Adhered effectively, the #coatings can hold for decades. Our Ligand-Free Quantum nanopowders can be: Doesed in (existing) #coating formulations Added to #composite materials Cold sintered With 20+ years of experience in quantum nanotechnology, our #consultancy services guide you in surface #nanoengineering. We also supply Quantum Nanopowders & custom-developments to meet unique needs. Request Service at https://lnkd.in/edBb_ya #advancedmaterials

Every industry faces a disrutption. In the #concrete sector, this disruption comes from quantum-phase #nanotechnology, where counterintuitively minute volumes of nanomaterial, are capable of enhancing concrete performance and offering an alternative to conventional cement products, to enable high performance, low #carbonfootprint #construction - in one step. NANOARC's Construction #Nanomaterials Division offers an advanced nano-cement for concrete performance enhancement at a low carbon footprint called QUANTCRETE CURE. It is well known, that the specific surface area (blaine) of a material determines both its performance and dosage requirements, in concrete. Here is how #QuantCrete CURE ranks with #cement products: General Purpose Cement : 3200–3800 cm2·g−1 Rapid Hardening Cement : 4500 – 6500 cm2·g−1 QuantCrete CURE NanoCement : 388000 cm2·g−1 The Ultra-High blaine of QuantCrete CURE cannot be obtained by grinding, it is achieved with advanced nanochemistry sysnthesis processes. QuantCrete CURE Dosage in concrete : 2.7g per cubic metre ( 0.08 oz per cubic yard) Average Compressive Strength Gain : 18 - 20% CO2 reduction per cubic meter : min. 216 kg QuantCrete CURE is manufactured using sustainable chmeistry techniques without the emissions associated with traditional (portland) cements. Low Shipment Costs: Its ultra-high blaine enables not only a low dosage, but reduces transportation costs, maximised at $105, for rapid worldwide shipping. This more than compensates for the high shipment costs associated with conventional cement, especially to remote locations. For example, 1kg (2.2 lb) of QuantCrete CURE is viable for 370 m3 (440 Yd3) of concrete, shipped worldwide at $105. NANO-CEMENT BENEFITS: QuantCrete CURE is a nano-cementitious #admixture designed to offset the negative impact of #flyash and #GGBS on the early-age properties of concrete. It improves #workability without the use of #superplasticizers, acts as an effective Nano-Filler to reduce #porosity and enhance the compressive strength reinforcement of concrete #mortar & cement paste. CONCRETE REPAIR: - As a nanofiller of remnant harmful pores - As a nucleation site for cement particles to densify concrete without increasing its weight and - Helps in the consolidation of unsound formations, repairing casing leaks in squeeze operations, particularly “tight” leaks that are inaccessible to microfine & conventional cement slurries due to their larger particle size and limited penetrability. Don't just take our word for it, this is verifiable #science. Simply test the product and get a firsthand experience of quantum nanotechnology in concrete.  QuantCrete CURE is available for purchase exclusively on our website at https://lnkd.in/eg3uZqH5 #sustainableconstruction #admixtures #cementindustry #concreterepair

The long-term operation of #dentalimplants is challenged by implant-related infections, hardness & inadequate osseointegration. Avoiding implant failure is one of the fundamental reasons for surface modification of a dental implant because early bacterial colonisation can occur within minutes after implantation by microorganisms associated with #periodontitis. In circumstances involving peri-implantitis, although conventional therapy has the ability to decrease the population of several periodontal pathogens, microbiological parameters sometimes tend to revert to pretreatment values, showing elevated counts for several target microorganisms roughly 30 days after treatment. It is crucial to have more sustainable solutions to prevent infection and peri-implantitis so as to increase the succes rate of implants and the durability of dental resin fillings. #Nanotechnology, enables the development of surface modifications that can mitigate these issues. NANOARC #Biomimetics uses #nanoengineering to design & manufacture #biocompatible, functional quantum-phase #nanomaterials for integration within implants, to improve the osseointegration, soft-tissue integration of dental implants and resistance to pathogenic infection. #Quantum effects in nanomaterials occur at specific dimension (< 20 nm), offering a singular modification of the zone of inhibition (ZOI) of antimicrobial materials, for effective implant success and longterm protection. The ZOI is the clear zone surrounding an #antimicrobial agent, indicating a complete absence of bacteria on, or within a given perimeter, from an antimicrobial agent. The size of a ZOI depends on the antimicrobial agent composition, particle size and concentration. Quantum materials distinguish themselves from regular materials in terms of their exceptional performance e.g. while regular materials need photoactivation for antimicrobial functionality, quantum materials are effective in both illuminated and dark conditions, like the buccal cavity. The ZOI with quantum materials, can double or even quadruple that of regular antimicrobial materials, spanning several centimetres in radius. Dental fillings and implants designed with NANOARC Q-DENT nanoadditives can provide antimicrobial protection to adjacent teeth & deep into the root canal. Merely coating an implant or adding Q-DENT nanoadditives to a dental #composite or resin filling at very low concentrations, makes it hard for bacteria to proliferate as such providing lasting #dentalhealth. Q-DENT nanoadditives act as: - active biocompatible components within the composite of dental implants to improve the mechanical strength, osseointegration & soft-tissue integration of dental implants. - active transparent #nanocoatings for antimicrobial protection & better #osteoblast adhesion due to the biomimetic nature of the material, in promoting #bone growth. Learn more at https://lnkd.in/dqQpjyV #medicaldevices

When the #packaging used in preservation is designed with non-toxic functional materials that prohibit the proliferation of harmful pathogens that cause food and beverage damage, there is a reduced need for the use of toxic chemical preservatives, within food products themselves. NANOARC's Biomimetics Division offers advanced #nanotechnology solutions to help the #packagingindustry enhance the protective and functional spectrum capacity of their packaging products from #plastic and #glass #bottles to jars, #boxes, etc to enable a more effective and natural extension of product shelflife. How is this possible? The zone of inhibition (ZOI), is the clear zone surrounding an antimicrobial agent, indicating a complete absence of bacteria on, or within a given perimeter, from an antimicrobial agent. The size of a ZOI depends on the #antimicrobial agent composition, (nano)particle size and concentration. Quantum materials distinguish themselves from regular materials in terms of their unique and elevated performance, under cirumstances that other materials cannot function in. For example, in antimicrobial settings, quantum materials perform in both illumuntated and dark conditions while regular materials often need photoactivation. The ZOI with quantum materials, can often double or even quadruple that of regular (nano)materials. With quantum materials, the ZOI can span several centimetres and food packaging containers are only so wide in diameter. This advantage, means coated merely on a surface at very low concentrations, quantum materials can makes it hard for #bacteria to proliferate, within packaged food thus removing the need for harmful #foodadditives. The #nanoadditives we offer, can be used either as follows: - active components within the #composite of the packaging material for mechanical reinforcement, or as - active transparent #coatings within the packaging (e.g. for #antimicrobial protection) and - on the outer and or surface for e.g. light-damage protection on already manufactured #packaging and containers. Learn more about our solutions and purchase exclusively on our website at https://lnkd.in/d7TnpvK Get 10% Off your first purchase with the coupon : FIRSTBUY #foodandbeverages #packagingmaterials #glassindustry #foodsafety #biomimicry #nanomaterials #UVprotection #lightdamage

The strength of a material indicates the extent to which it can absorb energy or be deformed without fracturing. #Glass is currently reinforced with superficial treatments such as chemical coatings. The brittleness of the underlying glass itself, remains a matter to be addressed with surgical precision. A load applied to a material imparts a large amount of energy, creating a situation wherein it needs to respond, by reducing its overall energy. Beyond the elastic limit, brittle materials like glass dissipate this energy via the formation of new surfaces by cracking. To prevent crack formation in any material system, nature offers design cues. Nature stabilises itself by lowering the energy required for an event to occur. It's possible to reverse engineer this aspect, to make it hard for cracks to initiate & propagate in a material. Glass–nanoceramic composites offer versatile benefits for fracture toughness. #Nanoceramic crystallites with sizes small enough to prevent grain boundary formation dispersed within glass, act as prohibitors to crack formation. This is possible because when a propagating crack encounters such nanoceramic crystals, the crack will either try to change its propagation direction or move around the nanocrystal or initiate a new crack through the crystallite phase itself. However, when the nanocrystal is small enough to limit the formation of a grain boundary within itself, the probability of a fault site being generated therein, is prohibited. A dense, uniform dispersion of such nanoceramic crystals within a glass matrix, is crucial to frustrate crack formation as it creates an energetically unfavourable scenario that altogether limits or even eliminates it altogether. To create a crack-frustration scenario, nanoceramic crystals dimensions have to be far below 20 nm. The size range also prevents grain boundary formation in a nanocrystals. The nanoceramic crystal at that size can then be modified in its composition, to confer versatile functionality e.g. chemical, optical, electrical properties to the glass that help it be functional, surgically nano-tempered & superior in durability. A major challenge encountered during the preparation of glass-nanoceramic matrix nanocomposites, is the ability to achieve a homogeneous dispersion of nanocrystals, therein. A single 1000 nm particle can be replaced by 1000 particles 1 nm in size, facilitating their uniform dispersion within glass. Distribute a high density such grain-boundary-resistant nanoceramic particles within a glass or cermaic matrix & one obtains a more durable, crack-resistant material. NANOARC's core expertise in the design & industrial-scale manufacture of sub 20 nm sized nanoceramics offer composition flexibility for bespoke tuning of glass properties with superior durability, enhanced optical properties, pathogen protection, nuclear radiation attenuation & more. See https://lnkd.in/dXCXg2mA #nanotechnology #materialengineering

Radon (Rn) is a #radioactive, odourless, colourless, tasteless noble gas. Rn is a contaminant, that affects indoor #airquality worldwide. EPA policy-oriented estimates Rn as the number one cause of lung #cancer, among non-smokers. Rn enters a building most often directly through the soil at the lowest level of the construct that is in contact with the ground. This typical occurs through cracks in solid #foundations and walls, construction joints, gaps in suspended floors, cavities within walls and around service #pipes. A DIMENSION-BASED SOLUTION: Radioactive radon particles vary in size. - When attached to an #aerosol, Rn particles are ~ 50-300 nm (0.05 - 0.3 μm) - Unattached radon particles range from 3 - 5 nm (0.003 - 0.005 μm) QUANTCRETE IN #RADON MITIGATION: QuantCrete systems are NANOARC's proprietary #cement & #concrete #nanoadditives that help - improve #workability without the need for #superplasticizers - reduce #porosity - enhance densification - freeze-thaw resistance - rapid compressive and tensile strength gain   - #corrosion inhibition - increase concrete performance with less cement Essentially, QuantCrete #nanosystems confer durability & add safety to concrete. QuantCrete products have #nanoparticle sizes as small as 1nm (0.001 μm) i.e. 3 - 5 times smaller than unattached Rn particles & as such, #QuantCrete Systems are well poised to handle Rn remediation tasks. QuantCrete is hence offered to substantially lower porosity, Rn permeability and mitigate of crack formation in concrete & mortar. QuantCrete #nanoparticles are of the same size range as unattached radon particles. As such QuantCrete nanoparticles used to densify #concrete and can form a dense structure therein, acting as a physical as well as chemical barrier, to prevent the diffusion of Radon, through a basement concrete floor. THE BASIC PROTOCOL : To achieve this, the QuantCrete #nanopowder can be used as an integral ingredient in the manufacture of #precast slabs and #foundation concrete or, mixed with a liquid cement and injected within particularly hard to visualise and detect sub-micron and nanoscopic pores, cracks & cavities that cement particles can not reach or penetrate, in order to create a denser seal, that minimises the likelihood of Rn gas infiltrating the building, via its ground level and sub-terrain/basement walls. This nanotechnology-based approach offers a durable, sustainable, long term mitigation effort, to prevent Rn gas from entering the #building through concrete in #subterrain constructs, through the underlying or surrounding #soil. For existing systems, QuantCrete can be added to mortar to seal existing #concretefloors and subterrain surfaces. Learn more about QuantCrete SUBSEAL at https://lnkd.in/eRpj9xSV #nanotechnology #radon #sustainableconstruction #environmentalremediation #quantcrete #concreteconstruction #basements #radonmitigation #airpurification #airpollution

The indiscriminate use of #pesticides and #fertilisers has led to substantial #environmentalpollution, as well as the emergence of additional problems such as agricultural pests, #pathogens, and an increasing loss of #biodiversity. THE REMEDY #Nanotechnology, by virtue of superior properties leveraged by high surface area #nanomaterials, has the ability to furnish the agricultural sector with systems to potentiate the effective alleviation of these environmental problems. The very fine size, high specific surface area, reactivity and versatility of atomically-architectured materials, enables them to infiltrate sub-micron pores in soil readily to remove recalcitrant contaminants and achieve a selective targeting of contaminants in complex environmental media. Through nano-mineralisation with non-toxic, biocompatible nanomaterials it is possible to acquire the following benefits: - incorporation of essential nutrients into the soil - acidic soil pH remediation  - enable plant growth  - absorption/extraction of toxic chemicals and  - the protection of plants from dangerous pathogen, without the need for harsh chemical pesticides.   These benefits are attainable with very minute doses of well defined nanominerals, that make the essential active agents in their composition more bioavailable and essential to improving soil health, without negatively affecting the surrounding #ecosystem. NANOARC's RoofWall Division offers solutions for: - #heavymetal removal - nuclear waste remediation - organic compounds from #dyes as well as the #oilandgas industry - soil pathogens - soil pH remediation Our #nanominerals are supplied in #powder form. This enables flexible dosage depending on the nature of the #soilcontaminants, their concentration and the longterm needs for #remediation. Product dosage can be adjusted based on the sorption capacity of the nanomaterial and contaminant concentration. Learn more and purchase exclusively on our website at https://lnkd.in/dfrS2Ki Get 10% Off your first purchase with the coupon code : FIRSTBUY #environmentalremediation #soilremediation #wastemanagement #nuclearwaste #soilpathogens #scienceandenvironment #agriculture