Jardiance (empagliflozin) is a prescription drug that’s prescribed for type 2 diabetes, heart failure, and kidney disease. This drug can interact with alcohol, other medications, and some supplements and foods. For example, Jardiance can interact with glipizide.
Jardiance is prescribed to:
- children ages 10 years and older and adults with type 2 diabetes, to manage blood sugar levels
- adults with type 2 diabetes and cardiovascular (heart and blood vessel) disease, to lower the risk of dying from cardiovascular disease
- adults with heart failure, to lower the risk of needing hospital treatment or dying from the condition
- adults with chronic kidney disease, to lower the risk of worsening kidney function, needing hospital treatment, or dying from the condition
Jardiance contains the active drug empagliflozin. It comes as a tablet that you swallow.
An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.
Keep reading to learn about Jardiance’s possible interactions. And for more information about Jardiance, including details about its uses, see this article.
Before you start taking Jardiance, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Jardiance interacts with supplements, herbs, and vitamins, see the “Are there other interactions with Jardiance?” section below.)
If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.
The table below lists drugs that may interact with Jardiance. Keep in mind that this table does not include all drugs that may interact with Jardiance. For more information about some of these interactions, see the “Drug interactions explained” section below.
| Drug group or drug name | Drug examples | What can happen |
| insulin | • insulin degludec (Tresiba) • insulin glargine (Lantus, Basaglar) • insulin lispro (Humalog) • insulin regular (Humulin R) | can increase the risk of hypoglycemia (low blood sugar) |
| other diabetes medications | • glipizide (Glucotrol) • glyburide (Diabeta, Glynase) • nateglinide (Starlix) • repaglinide (Prandin) | can increase the risk of hypoglycemia |
| diuretics (fluid pills) | • bumetanide (Bumex) • furosemide (Lasix) • hydrochlorothiazide | can increase the risk of certain side effects of Jardiance and diuretics |
| lithium (Lithobid) | – | can make lithium less effective |
Certain health conditions or other factors could raise your risk of harm if you take Jardiance. In such cases, your doctor may not prescribe Jardiance for you. These are known as contraindications. Allergic reaction is the only contraindication of Jardiance.
If you’ve had an allergic reaction to Jardiance or any of its ingredients, your doctor likely won’t prescribe Jardiance. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.
Jardiance is not known to interact with alcohol. But Jardiance and alcohol can cause some similar side effects, such as increased urination, dizziness, and low blood sugar levels. So you may be more likely to experience these side effects if you drink alcohol during your Jardiance treatment.
Drinking large amounts of alcohol also raises your risk of ketoacidosis (high level of acid in your blood) with Jardiance. This is a serious side effect of Jardiance.
If you have questions about consuming alcohol while taking Jardiance, talk with your doctor or pharmacist.
Learn more about certain drug interactions that can occur with Jardiance.
Interaction with diuretics
Jardiance can interact with diuretics, which are used to treat fluid buildup and high blood pressure.
Examples of diuretic medications include:
- bumetanide (Bumex)
- furosemide (Lasix)
- hydrochlorothiazide
- torsemide (Soaanz)
What could happen
Jardiance and diuretics both increase urination and can lower the volume of fluid in your blood. Having a low volume of fluid in your blood can cause low blood pressure and kidney problems. So taking these drugs together can raise your risk of these side effects.
If you’re 65 years or older, you may have a higher risk of these side effects if you take Jardiance with a diuretic drug. You may also have a higher risk if you have kidney problems, low blood pressure, or follow a low salt diet.
What you can do
If you take Jardiance with a diuretic, your doctor may prescribe a lower dosage of Jardiance or the diuretic.
While taking these medications together, it’s important to drink enough fluids to avoid becoming dehydrated. Talk with your doctor if you’re not sure how much you should drink every day.
If you take Jardiance and a diuretic together, tell your doctor right away if you have symptoms of low blood pressure, such as feeling dizzy when standing up.
If you have questions about taking Jardiance with a diuretic, talk with your doctor or pharmacist.
Interaction with insulin
Jardiance can interact with insulin, which allows your cells to use blood sugar for energy.
Examples of insulin medications include:
- insulin lispro (Humalog)
- insulin detemir (Levemir)
- insulin degludec (Tresiba)
- insulin glargine (Lantus)
What could happen
Jardiance and insulin can both cause hypoglycemia (low blood sugar level). So taking these drugs together can raise your risk of this side effect.
What you can do
If you take Jardiance with an insulin, your doctor may prescribe a lower dosage of Jardiance or the insulin.
You’ll need to monitor your blood sugar level if you take Jardiance with an insulin. Talk with your doctor about when you should check your blood sugar levels.
If you have symptoms of hypoglycemia while taking these drugs together, you should eat or drink something containing fast-acting sugar right away. Hypoglycemia symptoms can include sweating, shakiness, blurry vision, dizziness, headache, and irritability. It’s a good idea to talk with your doctor about what you should do if you experience low blood sugar.
Tell your doctor right away if you’ve had an episode of hypoglycemia while taking Jardiance with insulin.
If you have questions about taking Jardiance with insulin, talk with your doctor or pharmacist.
Interaction with other diabetes medications
Jardiance can interact with certain other diabetes medications, which are used to help manage blood sugar levels in people with type 2 diabetes.
Examples of diabetes medications that can interact with Jardiance include:
- glipizide (Glucotrol)
- glyburide (Diabeta, Glynase)
- nateglinide (Starlix)
- repaglinide (Prandin)
What could happen
Jardiance and certain other diabetes medications can cause hypoglycemia. So taking these drugs together can raise your risk of this side effect.
What you can do
If you take Jardiance with other diabetes medications, your doctor may prescribe a lower dosage of Jardiance or the other diabetes medication.
Talk with your doctor about a low blood sugar action plan. If you have symptoms of hypoglycemia while taking these drugs together, you should eat or drink something containing fast-acting sugar right away. Hypoglycemia symptoms can include sweating, shakiness, blurry vision, dizziness, headache, and irritability.
Tell your doctor if you have episodes of hypoglycemia while taking Jardiance with other diabetes medications.
If you have questions about taking Jardiance with other diabetes medications, talk with your doctor or pharmacist.
Jardiance might have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Jardiance.
Does Jardiance interact with supplements?
Before you start taking Jardiance, talk with your doctor and pharmacist about any supplements, herbs, and vitamins you take. Sharing this information with them may help you avoid possible interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Jardiance and herbs
Jardiance may interact with certain herbal supplements. For example, it may interact with garlic supplements.
Garlic supplements may lower blood sugar levels. Consuming garlic supplements while taking Jardiance could increase your risk of hypoglycemia (low blood sugar level).
It’s important to check with your doctor or pharmacist before taking any herbal supplements while taking Jardiance.
Jardiance interactions with vitamins and minerals
Jardiance can interact with the mineral chromium, which some people take to help manage their blood sugar levels. Taking Jardiance with chromium supplements could raise your risk of hypoglycemia.
It’s important to check with your doctor or pharmacist before taking any vitamin or mineral supplements while taking Jardiance.
Does Jardiance interact with food?
Jardiance may interact with certain foods. For example, it may interact with green tea.
Green tea may increase your cell’s sensitivity to insulin. This could cause lower blood sugar levels. Consuming green tea while taking Jardiance could increase your risk of hypoglycemia.
Jardiance can also interact with a ketogenic diet. This is a diet that’s high in healthy fats and low in carbohydrates. Following this type of diet while taking Jardiance can raise your risk of a serious side effect called ketoacidosis (high level of acid in your blood). If you follow this type of diet, talk with your doctor before taking Jardiance.
Talk with your doctor if you have questions about eating certain foods or following special diets while taking Jardiance.
Does Jardiance interact with vaccines?
There are currently no reports of Jardiance interacting with vaccines. If you have questions about getting certain vaccines during your Jardiance treatment, talk with your doctor.
Does Jardiance interact with lab tests?
Jardiance can interact with the following lab tests:
- urine glucose, which is a test that measures the amount of glucose (sugar) in your urine
- 1,5-anhydroglucitol (GlycoMark) assay, which is a test that measures how well your blood sugar has been controlled over the past 1–2 weeks
If you’re taking Jardiance, your doctor will recommend different tests to gather this information.
Does Jardiance interact with cannabis or CBD?
There are currently no reports of Jardiance interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Jardiance.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Certain medical conditions or other health factors may raise the risk of interactions with Jardiance. Before taking Jardiance, talk with your doctor about your health history. They’ll determine whether Jardiance is right for you.
Health conditions or other factors that might interact with Jardiance include:
Kidney problems. If you have certain kidney problems, Jardiance may not be right for you. Talk with your doctor about any kidney problems you have before starting Jardiance. They may recommend a different medication for you.
Type 1 diabetes. If you have type 1 diabetes, your doctor will likely not prescribe Jardiance. This is because taking Jardiance could cause a serious side effect called ketoacidosis (high level of acid in your blood). Talk with your doctor about other treatment options.
Pancreas problems. If you’ve had past pancreas problems, such as pancreatitis (pancreas inflammation) or pancreas surgery, you may have a raised risk of ketoacidosis with Jardiance. Talk with your doctor about whether Jardiance is right for you.
Upcoming surgery or medical procedures. Certain surgeries and medical procedures may raise your risk of ketoacidosis with Jardiance. If you have any upcoming surgery or medical procedures, ask your doctor if you’ll need to stop taking Jardiance beforehand.
Dehydration. If you’re dehydrated, Jardiance could make this worse. This could raise your risk of low blood pressure and kidney problems. Your doctor will likely recommend measures to correct dehydration before you start taking Jardiance.
Low salt diet or ketogenic diet. Following a low salt diet or a ketogenic diet (one that’s high in fats and low in carbohydrates), may increase the risk of certain side effects with Jardiance. Talk with your doctor about your diet before you start taking Jardiance.
Genital yeast infections or urinary tract infections. Jardiance can increase your risk of getting a genital yeast infection. Jardiance also increases your risk of getting a urinary tract infections (UTI). If you have an ongoing genital yeast infection or UTI, or you keep getting these infections, talk with your doctor. They can recommend if Jardiance is right for you.
Pregnancy. It’s not known whether Jardiance is safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before taking Jardiance.
Breastfeeding. It is recommended to not take Jardiance while breastfeeding. If you’re breastfeeding or planning to breastfeed, talk with your doctor about your options.
Allergic reaction. If you’ve had an allergic reaction to Jardiance or any of its ingredients, your doctor will likely not prescribe Jardiance. This is because taking the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.
Find answers to some frequently asked questions about Jardiance and possible interactions.
Is there an interaction between Jardiance and metformin?
No. There’s no known interaction between Jardiance and metformin (Glumetza, Fortamet).
Jardiance and metformin are both prescribed to help manage blood sugar levels in adults and certain children with type 2 diabetes. Jardiance also has other uses in adults with type 2 diabetes, heart failure, and kidney disease.
It’s not uncommon for doctors to prescribe these drugs together. Both drugs help lower your blood sugar levels. Because of this, you may have a slightly higher risk of hypoglycemia (low blood sugar level) if you take these drugs together. But hypoglycemia is rare with the combination.
If you have questions about taking Jardiance with metformin, talk with your doctor or pharmacist.
Can you take metformin, glipizide, and Jardiance together?
Yes, doctors sometimes prescribe metformin (Glumetza, Fortamet), glipizide (Glucotrol), and Jardiance together. All three drugs are used to help manage blood sugar levels in adults with type 2 diabetes.
Jardiance, glipizide, and metformin all lower your blood sugar. Because of this, you may have a raised risk of hypoglycemia (low blood sugar level) if you take these drugs together. You’re more likely to have hypoglycemia if you take all three drugs than if you take Jardiance with just metformin (see above).
If you have questions about taking Jardiance with metformin and glipizide, talk with your doctor or pharmacist.
Can you take aspirin with Jardiance?
Yes, it should be safe to take Jardiance with aspirin. There’s no known interaction between these drugs.
Jardiance is used to help manage blood sugar levels in adults and certain children with type 2 diabetes. It’s also used to lower certain risks in adults with heart failure, heart disease, and kidney disease.
Low dose aspirin is used to help prevent heart attacks and strokes in certain adults. In higher doses, aspirin is used to relieve pain.
People with type 2 diabetes, heart failure, heart disease, and kidney disease may also have a risk of heart attack and stroke. So it’s not uncommon for doctors to prescribe Jardiance and low dose aspirin together.
However, if you’re taking Jardiance for heart failure or kidney disease, talk with your doctor before taking aspirin to relieve pain. Pain-relieving doses of aspirin may not be recommended for certain people with these conditions.
If you have other questions about taking Jardiance and aspirin together, talk with your doctor or pharmacist.
Taking certain steps can help you avoid interactions with Jardiance. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:
- Whether you drink alcohol or use cannabis.
- Other medications you take, as well as any vitamins, supplements, and herbs. Your doctor or pharmacist can help you fill out a
medication list . - What to do if you start taking a new drug during your Jardiance treatment.
It’s also important to understand Jardiance’s
If you have trouble reading or understanding this information, your doctor or pharmacist can help.
Taking Jardiance exactly as prescribed can also help prevent interactions.
If you still have questions about Jardiance and its possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- Does my risk of interactions depend on my dosage of Jardiance?
- Do I need to tell you if I change my diet while taking Jardiance?
- Do other drugs that could treat my condition have similar interactions?
To learn more about Jardiance, see these articles:
And to learn how Jardiance compares with some other similar drugs, see these articles:
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.