In order to apply ports and adapters to your application, you must first identify your domain model and logic, and define the ports that represent the inputs and outputs of your application. This could include user authentication, product catalog, order processing, payment processing, etc. After that, you should implement your domain layer using the ports as interfaces or contracts, avoiding any dependency on the infrastructure layer. This can be done through the use of dependency injection or inversion of control to inject the ports into your domain services or entities. Then, you need to implement your infrastructure layer using the adapters that match the ports. You can use different technologies or frameworks to interact with the external world such as an ORM adapter for your database, a web framework adapter for your API, or a messaging adapter for your event bus. Lastly, you need to connect your domain layer and your infrastructure layer using the ports and adapters and configure them accordingly. You can do this with a dependency injection container or a factory method to create and wire up the adapters to the ports.