3Helix, Inc.

🧬 Did you know that understanding collagen remodeling is a critical in wound healing research? Collagen remodeling governs how tissues regenerate after injury, yet tracking this process has long been a challenge for researchers. CHPs bind to denatured collagen, helping researchers map damaged areas and track new collagen formation during tissue repair. By revealing how fibroblasts interact with their environment and identifying disruptions in collagen turnover, CHPs help researchers understand why chronic wounds fail to heal and how excessive scarring develops in fibrosis. Curious how CHPs can improve your research? Let's connect! #CollagenResearch #WoundHealing #Fibrosis

🧬 Did you know that understanding collagen remodeling is a critical in wound healing research? Collagen remodeling governs how tissues regenerate after injury, yet tracking this process has long been a challenge for researchers. CHPs bind to denatured collagen, helping researchers map damaged areas and track new collagen formation during tissue repair. By revealing how fibroblasts interact with their environment and identifying disruptions in collagen turnover, CHPs help researchers understand why chronic wounds fail to heal and how excessive scarring develops in fibrosis. Curious how CHPs can improve your research? Let's connect! #CollagenResearch #WoundHealing #Fibrosis

🚨 Breaking Down Barriers in Solid Tumor Research 🚨 Full Blog👉https://lnkd.in/eheYq6fK While CAR-T therapy has revolutionized cancer treatment, its success in solid tumors—like pancreatic ductal adenocarcinoma (PDAC)—has been limited. Why? The dense extracellular matrix (ECM) and stromal cells create a near-impenetrable barrier, blocking immune cells from reaching the tumor. Here’s where Collagen Hybridizing Peptides (CHPs) play a game-changing role: 🔍 Researchers used B-CHP to precisely detect and measure ECM depletion after FAP-CAR T cell treatment, proving that stromal-targeted therapies can reduce collagen and enhance T cell infiltration. 📈 With CHPs, researchers gain the critical insights needed to optimize immunotherapy strategies for these challenging cancers. 💡 Learn how CHPs helped expose tumors to life-saving immunotherapies in this pivotal study. Let’s keep pushing the boundaries of what’s possible in cancer research! #Oncology #Immunotherapy #SolidTumors #Collagen #ResearchTools #Biotech #LifeSciences

🚨 Breaking Down Barriers in Solid Tumor Research 🚨 Full Blog👉https://lnkd.in/eheYq6fK While CAR-T therapy has revolutionized cancer treatment, its success in solid tumors—like pancreatic ductal adenocarcinoma (PDAC)—has been limited. Why? The dense extracellular matrix (ECM) and stromal cells create a near-impenetrable barrier, blocking immune cells from reaching the tumor. Here’s where Collagen Hybridizing Peptides (CHPs) play a game-changing role: 🔍 Researchers used B-CHP to precisely detect and measure ECM depletion after FAP-CAR T cell treatment, proving that stromal-targeted therapies can reduce collagen and enhance T cell infiltration. 📈 With CHPs, researchers gain the critical insights needed to optimize immunotherapy strategies for these challenging cancers. 💡 Learn how CHPs helped expose tumors to life-saving immunotherapies in this pivotal study. Let’s keep pushing the boundaries of what’s possible in cancer research! #Oncology #Immunotherapy #SolidTumors #Collagen #ResearchTools #Biotech #LifeSciences

January is Cervical Health Awareness Month! This is an important time to highlight advancements in reproductive health research, particularly in understanding how collagen supports the pelvic organs. At 3Helix, we’re proud that our Collagen Hybridizing Peptides (CHPs) are being used in studies to explore tissue health and integrity in reproductive systems. Researchers at UIUC and CU Boulder have shown that uterosacral ligaments (USLs) undergo significant collagen-related changes during pregnancy and aging. In their recent study, CHPs were used to visualize and quantify collagen damage in USLs under mechanical strain. By binding selectively to damaged collagen, CHPs enabled in situ staining and detailed damage mapping during repeated deformation cycles. This innovative use of CHPs provided crucial insights into how USLs adapt to pregnancy-induced remodeling and age-related stiffness changes, aiding the study of pelvic tissue health and potential treatments for related conditions. Pregnancy induces extracellular matrix remodeling in USLs, including an increase in collagen content and a decrease in elastin. This leads to greater tissue compliance and resilience against mechanical strain-induced collagen damage during pregnancy. Conversely, with aging, USLs exhibit increased stiffness likely due to changes in collagen crosslinking, which may reduce their ability to recover from mechanical stress. Enabling precise visualization of collagen damage and remodeling helps researchers uncover new insights into how these tissues respond to mechanical strain and injury, potentially guiding future prevention and treatment strategies. We remain committed to supporting groundbreaking research in women’s health and beyond! Study: https://lnkd.in/enZEEzUf

Is quantifying collagen VI enough to understand COL6-Related Dystrophies? Collagen VI-related dystrophies are genetic muscle disorders causing weakness, joint contractures, and respiratory issues. Diagnosis often relies on measuring collagen VI expression levels, but this doesn’t tell the whole story. Some patients show normal collagen expression, yet face severe symptoms. Why? The answer lies in collagen disorganization within the ECM. New research using Collagen Hybridizing Peptides reveals how structural disarray contributes to disease progression. Their approach not only improves diagnostic precision, but also helps evaluate therapies by distinguishing treatments which increase collagen expression from those which restore proper collagen organization. 🧬Learn how CHPs are transforming COL6-RD research! https://lnkd.in/e6ZCEG7a

Is quantifying collagen VI enough to understand COL6-Related Dystrophies? Collagen VI-related dystrophies are genetic muscle disorders causing weakness, joint contractures, and respiratory issues. Diagnosis often relies on measuring collagen VI expression levels, but this doesn’t tell the whole story. Some patients show normal collagen expression, yet face severe symptoms. Why? The answer lies in collagen disorganization within the ECM. New research using Collagen Hybridizing Peptides reveals how structural disarray contributes to disease progression. Their approach not only improves diagnostic precision, but also helps evaluate therapies by distinguishing treatments which increase collagen expression from those which restore proper collagen organization. 🧬Learn how CHPs are transforming COL6-RD research! https://lnkd.in/e6ZCEG7a

Thank you to all the researchers who advanced collagen science in 2024. We’re proud that CHPs could support your work. Here’s to a 2025 filled with new discoveries and progress! Happy New Year!

How can we better understand inflammation in 3D tissue models? 🧬 🔬 Chronic inflammation damages tissues and contributes to various diseases. The TRPV4 calcium ion channel plays a key role, promoting pro-inflammatory macrophages and cytokine release when activated. Researchers used 3D collagen tissue models and Collagen Hybridizing Peptides (CHPs) to visualize TRPV4’s impact on the surrounding ECM. 🗝️ Key Findings: 🧬Collagen Damage: CHPs revealed increased collagen degradation with TRPV4 activation. 🏗️ Structural Changes: CHPs pinpointed specific regions of collagen damage, not possible with Masson’s Trichrome staining   🥼 Therapeutic Potential: Blocking TRPV4 reduces collagen damage and shifts macrophages towards an anti-inflammatory phenotype. By enabling precise visualization of ECM remodeling, CHPs offer a deeper, more accurate understanding of inflammation in 3D tissue models, paving the way for targeted therapies.

How can we better understand inflammation in 3D tissue models? 🧬 🔬 Chronic inflammation damages tissues and contributes to various diseases. The TRPV4 calcium ion channel plays a key role, promoting pro-inflammatory macrophages and cytokine release when activated. Researchers used 3D collagen tissue models and Collagen Hybridizing Peptides (CHPs) to visualize TRPV4’s impact on the surrounding ECM. 🗝️ Key Findings: 🧬Collagen Damage: CHPs revealed increased collagen degradation with TRPV4 activation. 🏗️ Structural Changes: CHPs pinpointed specific regions of collagen damage, not possible with Masson’s Trichrome staining   🥼 Therapeutic Potential: Blocking TRPV4 reduces collagen damage and shifts macrophages towards an anti-inflammatory phenotype. By enabling precise visualization of ECM remodeling, CHPs offer a deeper, more accurate understanding of inflammation in 3D tissue models, paving the way for targeted therapies.