Anatomic Incorporated

🚨 New Insights into Chronic Pain within the Spinal Cord 🚨 A new study links decreased KCC2 expression in the human dorsal horn to chronic pain and long-term opioid use. KCC2 regulates chloride gradients essential for inhibitory neurotransmission, and its dysregulation is a hallmark of neuropathic pain. Read the full preprint here: https://lnkd.in/gQ-k7xCK These results highlight the critical role of decreased dorsal horn inhibitory efficacy in chronic pain and support the development of therapeutics aimed at enhancing KCC2 function.

💡 Did you know that Paclitaxel, a chemotherapy drug commonly associated with chemotherapy-induced peripheral neuropathy (CIPN), was first approved by the FDA in 1992 for ovarian cancer? When dosed with Paclitaxel, immunocytochemistry imaging shows a dose response in cytotoxicity in both monocultures and co-cultures of sensory neurons and Schwann cell precursors (SCPs). Interestingly, there appear to be differential effects between the monoculture and co-culture systems, suggesting that SCPs may influence how sensory neurons respond to Paclitaxel-induced cytotoxicity. Reach out for the full poster #CompleteTheCircuit #NotYourAverageNeuron #CIPN #PainResearch

🔎How do you “spot” a melanocyte? You look with your naked eye! With RealMELO, Anatomic is going MACROSCOPIC! If your drug screen readout is pigmentation, the effects will be obvious in as little as 7 days post-thaw! ✔️Check it out at https://lnkd.in/gFFKZ_Jc #CompleteTheCircuit #NotYourAverageNeuron #Vitiligo #Melanoma #Cosmetics

From the Field 📰 We’re pleased to announce a new preprint that highlights the use of RealDRG human iPSC-derived nociceptors in a cutting-edge platform for studying axonal electrophysiology. The platform combines MaxWell Biosystems high-density microelectrode arrays with polydimethylsiloxane (PDMS) microstructures, enabling researchers to distinguish nociceptor subtypes and measure their electrophysiological responses. This work could significantly improve the screening of drugs targeting specific nociceptors involved in neuropathic pain. Dive into the full study here: https://lnkd.in/gKAv4Pe7 Congrats to the authors: Blandine Clément, Lorenzo Petrella, Lea Wallimann, Jens Duru, Christina Tringides, Janos Vörös, Dr. Tobias Ruff #notyouraverageneuron #pain #capsaicin #TRPV1

Sensory neurons and Schwann cells are better together❣️Whether you are single or have date night plans, this is a scientific love story that you can study this Valentine’s day. Learn more about our co-cultures at https://lnkd.in/gjuseJTz #CompleteTheCircuit #NotYourAverageNeuron #PainResearch #CoCultures #CMT

Excited to attend BPS 2025 Drug Discovery Satellite Meeting in Los Angeles, CA on February 14th. Looking forward to learning about the latest advancements in ion channel drug discovery. Interested in learning about how you can #CompleteTheCircuit? Reach out to set up a meeting with Vincent Truong

🔬👩🔬Twitch isn’t only for gamers. See motor neuron-induced myofiber contraction in our neuromuscular junction (NMJ) assay using Anatomic’s new RealMOTO hiPSC-derived motor neurons! Industry-leading directed differentiation speed resulting in industry leading purity! Check out our posters on our hiPSC-derived NMJ models: https://lnkd.in/g5j3AYuj #CompleteTheCircuit #NotYourAverageNeuron #ALS #CMT #StemCells #Microfluidics

Chemotherapy-induced peripheral neuropathy (CIPN) is a major challenge in oncological treatments - often requiring dose reduction or cessation and impacting survival (L Colvin 2019). It’s been recently demonstrated that a class of small molecule Sarm1 NADase inhibitors can protect axonal structure and function, both in vitro and in animal models of CIPN (Bosanac et al. 2021). With the goal of generating a human DRG CIPN model using RealDRG™ hiPSC sensory neurons, we tested four common CIPN-related compounds (bortezomib, paclitaxel, vincristine, and oxaliplatin) on 7 day cultures. Preliminary findings show that axonal density remains higher after bortezomib treatment with a pre-treatment of DSRM-3716 (a selective inhibitor of SARM1 NADase). We have ongoing studies in axonal compartmentalization devices to investigate these phenotypes further. Reach out if you’d like to learn more about our work in this space at support@anatomic.com! #NotYourAverageNeuron #CompleteTheCircuit #StemCells #CIPN #Pain

Motor neurons 🤝 Schwann cell precursors While motor neurons are a great model for ALS, the addition of Schwann cell precursors (SCPs) can enhance their physiological relevance to create a better model. As the co-culture matures over time, the SCPs align with the extending axons as the first step of myelination! Reach out for more details on our co-cultures: support@anatomic.com #CompleteTheCircuit #NotYourAverageNeuron

That’s a wrap on #SLAS2025 - first conference of the year complete ✅ Thrilled to have the opportunity to present our most recent work on integrating Schwann cells with our CIPN sensory neuron model, as well as our progress with other cell types. We’re grateful to have the chance to learn, collaborate and share our innovations. Excited to take these learnings forward and keep the momentum going! If you missed any of our posters, reach out for a copy or to learn more about how we can help you #CompleteTheCircuit