Day Zero Diagnostics, Inc

There’s a great new preprint from the team at Copenhagen University Hospital on the utility of genomic surveillance for #InfectionPrevention: 📊 Over 28 months, they sequenced isolates from 7,760 patient infections and found that 27.1% were genetically related—meaning they were part of an outbreak. This is all undetected transmission through current IP&C methods!! 🏥 Using geo-temporal thresholds, they identified epidemiological links in 69% of cases, further supporting the role of transmission within the hospital. 💰 Importantly, they modeled the financial impact and found that proactive IP&C interventions based on genomic surveillance could result in €1.25 million in net savings per year. This adds to the growing body of evidence showing that WGS-informed surveillance consistently uncovers transmission at levels traditional methods miss. Despite this, it remains underutilized in infection prevention programs. ➡️ How much more evidence do we need before it becomes standard practice? 📄 Pre-print linked here, and below: https://lnkd.in/ezyUAZPC

This week's World AMR Awareness Week is a reminder of the urgent need to act now to tackle the escalating global health challenge that is antimicrobial resistance. The Novo Nordisk Foundation is proud to be a funder of CARB-X, a global non-profit partnership accelerating antibacterial innovation by supporting the development of new antibiotics and other life-saving products.   CARB-X's diverse portfolio includes early-stage antibacterial projects by Day Zero Diagnostics, Inc and Vedanta Biosciences, Inc., which are pioneering innovative tools to prevent, diagnose, and treat the most dangerous drug-resistant bacterial infections. #AMR #WAAW #WAAW2024 #AntibioticAwarenessWeek #AntibioticResistance

The DANGER and IMPACT of the global problem of Antimicrobial Resistance (AMR) has just been re-quantified in an excellent publication in the The Lancet: "Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050". AMR has become - and will worsen - into a catastrophic "silent pandemic". 𝙈𝙖𝙞𝙣 𝙛𝙞𝙣𝙙𝙞𝙣𝙜𝙨 𝙧𝙚𝙡𝙖𝙩𝙚𝙙 𝙩𝙤 𝘼𝙈𝙍 𝙛𝙧𝙤𝙢 1990-2021: - While AMR deaths decreased in children under 5 years old, 𝘼𝙈𝙍 𝙙𝙚𝙖𝙩𝙝𝙨 𝙞𝙣𝙘𝙧𝙚𝙖𝙨𝙚𝙙 >80% 𝙛𝙤𝙧 𝙖𝙙𝙪𝙡𝙩𝙨 >70 𝙮𝙚𝙖𝙧𝙨 𝙤𝙡𝙙. - For Gram-negative bacteria, 𝙧𝙚𝙨𝙞𝙨𝙩𝙖𝙣𝙘𝙚 𝙩𝙤 𝙘𝙖𝙧𝙗𝙖𝙥𝙚𝙣𝙚𝙢𝙨 𝙞𝙣𝙘𝙧𝙚𝙖𝙨𝙚𝙙 𝙢𝙤𝙧𝙚 𝙩𝙝𝙖𝙣 𝙖𝙣𝙮 𝙤𝙩𝙝𝙚𝙧 𝙖𝙣𝙩𝙞𝙗𝙞𝙤𝙩𝙞𝙘 𝙘𝙡𝙖𝙨𝙨, rising from 619K to 1 Million “associated” deaths and from 127K to 216K directly “attributable” deaths - Regions with the highest AMR mortality rate in 2050 are forecasted to be 𝙨𝙤𝙪𝙩𝙝 𝘼𝙨𝙞𝙖 𝙖𝙣𝙙 𝙇𝙖𝙩𝙞𝙣 𝘼𝙢𝙚𝙧𝙞𝙘𝙖 𝙖𝙣𝙙 𝙩𝙝𝙚 𝘾𝙖𝙧𝙞𝙗𝙗𝙚𝙖𝙣 - Increases in deaths attributable to AMR in 2050 will be 𝙡𝙖𝙧𝙜𝙚𝙨𝙩 𝙖𝙢𝙤𝙣𝙜 𝙩𝙝𝙤𝙨𝙚 >70 𝙮𝙚𝙖𝙧𝙨 𝙤𝙡𝙙 - A cumulative 11.1 million AMR deaths could be averted through the development of a Gram-negative drug pipeline addressing AMR pathogens https://lnkd.in/edWBWtRW

Excited to share our latest pre-print on two years of real-time bacterial genomic surveillance for healthcare outbreak detection and mitigation! In this work, we demonstrate that: 1. Weekly bacterial genomic surveillance is not only feasible but impactful. 2. We successfully detected multiple outbreaks early. 3. Directed IP&C interventions. 4. 95% of outbreaks were stopped. 5. We modeled 𝟲𝟮 𝗽𝗿𝗲𝘃𝗲𝗻𝘁𝗲𝗱 𝗶𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻𝘀. 🏥 6. All of this led to $𝟲𝟵𝟱,𝟳𝟬𝟲 𝗡𝗘𝗧 𝗰𝗼𝘀𝘁 𝘀𝗮𝘃𝗶𝗻𝗴𝘀. 💰 Our previous retrospective study showed the potential of WGS surveillance for (https://lnkd.in/e-f7QpEu): • Detecting high-impact outbreaks that often go unnoticed. • Preventing infections. • Producing net cost savings. 𝗛𝗼𝘄𝗲𝘃𝗲𝗿, 𝘁𝗵𝗮𝘁 𝘀𝘁𝘂𝗱𝘆 𝘄𝗮𝘀𝗻’𝘁 𝗰𝗼𝗻𝗱𝘂𝗰𝘁𝗲𝗱 𝗶𝗻 𝗿𝗲𝗮𝗹-𝘁𝗶𝗺𝗲, 𝗻𝗼𝗿 𝗱𝗶𝗱 𝗶𝘁 𝗶𝗻𝘃𝗼𝗹𝘃𝗲 𝗜𝗣&𝗖 𝗶𝗻𝘁𝗲𝗿𝘃𝗲𝗻𝘁𝗶𝗼𝗻𝘀. Now, we've shifted to real-time, weekly bacterial genomic surveillance, detecting outbreaks as they occur and alerting IP&C teams. In just two years, we found: • 3,921 unique infections. • 476 patients involved in 172 outbreaks. • Many fascinating outbreak dynamics that we captured early. • After implementing IP&C interventions, 95.6% of outbreaks stopped along the intervened transmission route. Using a modeling approach & our prior data, we estimated that our interventions 𝗽𝗿𝗲𝘃𝗲𝗻𝘁𝗲𝗱 𝗮𝗽𝗽𝗿𝗼𝘅𝗶𝗺𝗮𝘁𝗲𝗹𝘆 𝟲𝟮 𝗶𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻𝘀, or 21%—which aligns with prior estimates. The financial impact: The comparison of WGS surveillance costs versus the cost of treating infections resulted in 𝗻𝗲𝘁 𝘀𝗮𝘃𝗶𝗻𝗴𝘀 𝗼𝗳 $𝟲𝟵𝟱,𝟳𝟬𝟲 𝗼𝘃𝗲𝗿 𝘁𝘄𝗼 𝘆𝗲𝗮𝗿𝘀. A sensitivity analysis further confirmed that cost savings occurred in 98% of simulations with varying inputs. While there are many important points discussed in the pre-print, 𝘄𝗲 𝗯𝗲𝗹𝗶𝗲𝘃𝗲 𝘁𝗵𝗶𝘀 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵 𝗰𝗼𝘂𝗹𝗱 𝗯𝗲𝗰𝗼𝗺𝗲 𝘀𝘁𝗮𝗻𝗱𝗮𝗿𝗱 𝗽𝗿𝗮𝗰𝘁𝗶𝗰𝗲 𝗳𝗼𝗿 𝗵𝗲𝗮𝗹𝘁𝗵𝗰𝗮𝗿𝗲 𝗳𝗮𝗰𝗶𝗹𝗶𝘁𝗶𝗲𝘀. Current methods often miss outbreaks, while WGS surveillance can not only detect and stop them early but also save money. #healthcare #infectionprevention #genomics Link here or PDF below!: https://lnkd.in/eJpAbgeh

If you happen to be around at ASM Microbe on Saturday, June 15, we invite you to visit our poster: Rapid Species ID and AST Direct from Whole Blood: Initial Results from a Feasibility Study in Patients with Suspected Blood Stream Infection presented by Nicole Billings. #DZD #WGS #rapiddiagnostics #antimicrobialresistance #sepsis