Drug Development and Industrial Pharmacy

🔬 New Research article Alert! published in #DrugDevIndPharm 🌟 Exploration of synergistically engineered invasomes of fluconazole incorporated with safranal against onychomycosis for enhanced transungual delivery 🌟 This study explores the development of a novel fluconazole-loaded invasomal formulation (FLU-IN) for enhanced transungual delivery in treating onychomycosis. Using Box-Behnken design, researchers optimized the formulation, achieving nanovesicles with 140.3 nm size, 74.65% entrapment efficiency, and 0.1604 polydispersity index. The FLU-IN gel demonstrated superior in vitro release, nail permeation, and antifungal activity against T. rubrum, N. glabrata, and C. albicans compared to conventional fluconazole gel. Confocal microscopy revealed deeper penetration into nail tissue, while skin irritation studies confirmed the formulation's safety. This innovative approach shows promise in improving the efficacy of fluconazole for onychomycosis treatment through enhanced transungual delivery. 📖 Read the full article here: https://lnkd.in/gr_d-zdk #NanoMedicine #DrugDelivery #Onychomycosis #PharmaceuticalInnovation #AntifungalTherapy #TransungualDelivery #NanoFormulation #DrugDevelopment #BiomedicalResearch #PharmaTech

🔬 New Research article Alert! published in #DrugDevIndPharm 🌟 Synthesis of a PVA-GO drug delivery system for sustained release of 4-methyl umbelliferon 🌟  fi This study presents a novel drug delivery system for 4-methyl umbelliferon (4MU), a coumarin with various therapeutic properties. The researchers developed a complex of polyvinyl alcohol (PVA), graphene oxide (GO), and 4MU to enhance the drug's durability and release profile. The PVA-4MU-GO complex demonstrated sustained release of 4MU over 160 hours, compared to just 7 hours for the pure drug. Characterization techniques confirmed the successful formation of the complex, while cytotoxicity studies on H9C2 cells revealed that the complex's toxicity depends on the ratio of 4MU to GO. Flow cytometry analysis showed gradual penetration of the complex into cells over 24 hours. This innovative approach could potentially expand 4MU's applications in medicine by improving its efficacy and prolonging its presence in the body. 📖 Read the full article here: https://lnkd.in/gvsKdUwu #DrugDelivery #Nanotechnology #PharmaceuticalResearch #ControlledRelease #Biomaterials #MedicalInnovation #DrugDevelopment #Nanomedicine

🔬 New Research article Alert! published in #DrugDevIndPharm 🌟 Chitooligosaccharide-modified PLGA-loaded PPD nanoparticles ameliorated sepsis-associated acute kidney injury via the NF-κB signaling pathway 🌟 This study investigates the potential of chitooligosaccharide-modified PLGA-loaded protopanaxadiol (COS-PLGA-PPD) nanoparticles in treating sepsis-associated acute kidney injury (SA-AKI). The researchers successfully prepared and characterized these nanoparticles, demonstrating their stability and improved bioavailability compared to free PPD. In vitro and in vivo experiments showed that COS-PLGA-PPD nanoparticles effectively reduced inflammation and kidney damage by inhibiting the NF-κB signaling pathway. The nanoparticles exhibited sustained release properties and enhanced oral bioavailability, making them a promising candidate for SA-AKI treatment. This research provides valuable insights into the use of nanomedicine for improving the therapeutic efficacy of natural compounds in treating complex conditions like SA-AKI. 📖 Read the full article here: https://lnkd.in/gYe__bhk #Nanomedicine #AcuteKidneyInjury #DrugDelivery #Inflammation #Sepsis #Protopanaxadiol #PLGA #Chitooligosaccharide #PharmaceuticalResearch #BiomedicalEngineering

🔬 New Research Alert! published in #DrugDevIndPharm 🌟 Optimizing critical quality attributes of fast disintegrating tablets using artificial neural networks: a scientific benchmark study 🌟 This study explores the optimization of fast disintegrating tablets (FDTs) using artificial neural networks (ANN) and other machine learning models. The researchers developed a comprehensive dataset of 864 FDT batches, varying binder types, disintegrants, and other formulation parameters. They compared the performance of ANN, support vector machines, k-nearest neighbors, and linear regression in predicting critical quality attributes like hardness, friability, and disintegration time. ANN emerged as the superior model, achieving R² values up to 0.9550 and demonstrating robust generalization. The study validated the model's predictions through checkpoint batches and successfully optimized an acetylsalicylic acid FDT formulation using differential evolution. This approach offers a powerful tool for pharmaceutical formulation development, potentially reducing experimental trials and enhancing product quality. 📖 Read the full article here: https://lnkd.in/gbPse74Y #ArtificialIntelligence #PharmaceuticalInnovation #MachineLearning #DrugFormulation #FastDisintegratingTablets #ANN #OptimizationTechniques #PharmaTech #DataScience #ResearchAndDevelopment

🔬 New Research Alert! published in #DrugDevIndPharm 🌟 Effect of processing parameters on characteristics of biodegradable extended-release microspheres containing leuprolide acetate 🌟 A recent study published in Drug Development and Industrial Pharmacy explores the effects of processing parameters on biodegradable extended-release microspheres containing leuprolide acetate. The research, conducted by Ngo Giao Thong and colleagues, investigates how various factors influence the characteristics of PLGA microspheres, including loading capacity, particle size, and initial burst release. The study demonstrates the adsorption ability of PLGA film and the ionic interactions between leuprolide acetate and PLGA in phosphate buffer. Using a double emulsion solvent evaporation method, the researchers examined ten processing parameters and their impact on microsphere properties. The findings reveal that factors such as drug concentration, polymer concentration, homogenization time, and PVA concentration significantly affect microsphere characteristics. The study provides valuable insights for optimizing the production of extended-release microspheres, which could lead to improved drug delivery systems for peptide-based medications. 📖 Read the full article here: https://lnkd.in/gXcepC8d #ExtendedRelease #DrugDelivery #Microspheres #PLGA #LeuprolideAcetate #PharmaceuticalResearch #ControlledRelease #Biodegradable #DrugFormulation #PharmaceuticalTechnology

🔬 New Research article Alert! published in #DrugDevIndPharm 🌟 Pyroligneous extract, a biomaterial derived from pyrolytic palm kernel shell wood vinegar, as a novel diabetic wound healing aid: an animal study 🌟 This study investigates the potential of pyroligneous extract (PE), derived from palm kernel shell wood vinegar, as a novel diabetic wound healing aid. Researchers incorporated PE into a chitosan-based hydrogel and tested its efficacy on streptozotocin-induced diabetic mice. The results showed that PE accelerated wound healing in a dose-dependent manner, with the highest concentration (150 μg/g-gel) performing as effectively as a commercial gel. PE treatment increased gene expression of cytokines and proteins in the TGF-β/SMAD signaling pathway, potentially restoring TGF-β levels downregulated by diabetes. The extract also enhanced expressions of Akt, FAK, RhoA, and Rac-1, and activated phosphorylation of Akt and FAK. Histological assessments revealed improved wound healing features in PE-treated groups. This research demonstrates the potential of PE as a promising biomaterial for treating chronic inflammatory wounds in diabetes 📖 Read the full article here: https://lnkd.in/gVcmMjYs #DiabeticWoundHealing #PyroligneousExtract #BiomaterialInnovation #RegenerativeMedicine #SustainableHealthcare

🔬 New Research Alert! published in #DrugDevIndPharm 🌟 Liposomal delivery of Annona muricata leaves extract for the treatment of hepatocellular carcinoma 🌟 This study explores the potential of liposomal delivery of Annona muricata leaves extract for treating hepatocellular carcinoma (HCC). Researchers developed and characterized liposomes loaded with methanolic extract from A. muricata leaves, which showed promising results in both in-vitro and in-vivo experiments. The extract demonstrated significant anticancer activity against human hepatoma cells (HEPG2) with an IC50 of 17 ± 1.8 μg/mL. The optimized liposomal formulation exhibited favorable characteristics, including a particle size of 107.2 ± 1.7 nm, zeta potential of -30.6 mV, and entrapment efficiency of 62.15%. In-vivo studies on Swiss albino mice revealed the formulation's potential efficacy in treating HCC, supported by histopathological evidence. This research highlights the promising role of A. muricata extract-loaded liposomes as a novel approach for HCC treatment. 📖 Read the full article here: https://lnkd.in/g9P_p3s2 #CancerResearch #Liposomes #NaturalMedicine #HepatocellularCarcinoma #DrugDelivery #PharmaceuticalInnovation #Phytotherapy

🔬 New Research Alert! published in #DrugDevIndPharm 🌟 Traditional Mongolian medicine Wu-Lan thirteen-flavor decoction protects rat from hypertension-induced renal injury via aryl hydrocarbon receptor-mediated pathway 🌟 ✨ Highlight: Wu-Lan Thirteen-Flavour decoction effectively protects hypertension-induced renal injury by regulating Aryl Hydrocarbon Receptor signalling pathway This study investigates the protective effects of Wu-Lan Thirteen-Flavor decoction (WLTd), a traditional Mongolian medicine, on hypertension-induced renal injury in rats. Using network pharmacology analysis, HPLC, and UPLC-MS/MS techniques, researchers identified key active components in WLTd, including flavonoids like quercetin and kaempferol. The study revealed that WLTd effectively lowered blood pressure, reduced BUN and creatinine levels, and mitigated renal damage in spontaneously hypertensive rats. The protective mechanism was found to involve the aryl hydrocarbon receptor (AhR) signaling pathway. In vitro experiments further confirmed WLTd's ability to upregulate AhR expression in angiotensin II-induced HEK293 cell injury. These findings suggest that WLTd offers a promising therapeutic approach for hypertension-related renal injury by modulating the AhR signaling pathway. 📖 Read the full article here: https://lnkd.in/g4iUsXnY #TraditionalMongolianMedicine #Hypertension #RenalProtection #NetworkPharmacology #AhRSignaling

🔬 New Research article Alert! published in #DrugDevIndPharm 🌟 Pyroligneous extract, a biomaterial derived from pyrolytic palm kernel shell wood vinegar, as a novel diabetic wound healing aid: an animal study 🌟 This study investigates the potential of pyroligneous extract (PE), derived from palm kernel shell wood vinegar, as a novel diabetic wound healing aid. Researchers incorporated PE into a chitosan-based hydrogel and tested its efficacy on streptozotocin-induced diabetic mice. The results showed that PE accelerated wound healing in a dose-dependent manner, with the highest concentration (150 μg/g-gel) performing as effectively as a commercial gel. PE treatment increased gene expression of cytokines and proteins in the TGF-β/SMAD signaling pathway, potentially restoring TGF-β levels downregulated by diabetes. The extract also enhanced expressions of Akt, FAK, RhoA, and Rac-1, and activated phosphorylation of Akt and FAK. Histological assessments revealed improved wound healing features in PE-treated groups. This research demonstrates the potential of PE as a promising biomaterial for treating chronic inflammatory wounds in diabetes 📖 Read the full article here: https://lnkd.in/gVcmMjYs #DiabeticWoundHealing #PyroligneousExtract #BiomaterialInnovation #RegenerativeMedicine #SustainableHealthcare

🔬 New Research article Alert! published in #DrugDevIndPharm 🌟In vitro evaluation of lipidic nanocarriers for mebendazole delivery to improve anticancer activity 🌟 This study explores the potential of repurposing mebendazole (MBZ), an anthelmintic drug, for lung cancer treatment using nanostructured lipid carriers (NLCs). The researchers developed MBZ-loaded NLCs with improved stability, encapsulation efficiency, and anticancer activity compared to free MBZ. The optimized formulation showed a 10-fold increase in potency against A549 lung cancer cells, with an IC50 of 62 nM compared to 581 nM for free MBZ. In vitro scratch assays demonstrated that MBZ-NLCs effectively inhibited cell migration. These promising results suggest that MBZ-NLCs could be a potent therapeutic approach for lung cancer treatment, warranting further in vivo studies and exploration of different administration routes. 📖 Read the full article here: https://lnkd.in/gufV4mTV #DrugRepurposing #CancerResearch #NanoMedicine #LungCancer #InnovativeTherapy