Elixir Associates

Exciting news from the San Antonio Breast Cancer Symposium 2024! Menarini Stemline (Stemline Therapeutics), with the Menarini Group and MEDSIR, presented game-changing research from the ADELA trial. This phase III study investigates a combo therapy for advanced ER+/HER2- breast cancer patients with ESR1 mutations, aiming to overcome therapeutic resistance 💪 The study highlights Elacestrant paired with Everolimus. Elacestrant is approved for its efficacy, while Everolimus is known for tackling resistance in breast cancer. ADELA's international scope could potentially extend survival and enhance the quality of life for patients. Preliminary data indicates this combination is effective and manageable in terms of safety ✅📊 If ADELA succeeds, new treatment options tailored to genetic profiles could emerge! 👏 #MenariniStemline #StemlineTherapeutics #BreastCancer #ClinicalTrials #ClinicalResaerch #CancerResearch #OncologyResearch #LifeScienceNews #ElixirAssociates

Exciting developments in gene therapy for wet AMD! 🌟 Exegenesis Bio has shared promising updates on their investigational candidates EXG102 and EXG202. EXG102 is administered via subretinal injection, while EXG202 offers a less invasive intravitreal injection, displaying significant improvements in retinal transduction efficiency. These advancements could revolutionise treatments for wet age-related macular degeneration (wet AMD). CEO Zhenhua Wu emphasised Exegenesis Bio's unique approach: targeting multiple neovascular disease pathways, utilising a proprietary capsid for targeted delivery, and opting for non-surgical administration. Clinical trials are underway in both the USA and China, with further data expected soon. This is a significant stride towards a global solution for wet AMD and other ocular diseases. Stay tuned for more updates during JP Morgan week in San Francisco next month! #GeneTherapy #Ophthalmology #ClinicalResearch

Good morning from a sunny Torrey Pines in California. 👋🏽☀️ - Elixir Associates It’s a beautiful part of the world & had the absolute pleasure of seeing Dolphins close up in person for the very first time. 🙏🏾 Over the last couple of days, myself & Jake Couldrick have had a chance to sit down with some of the most influential & entrepreneurial leaders across the biotech space. It’s insane how much hard work goes on behind the scenes at a startup biotech company & how not one day is ever the same. One of the most important things I’ve taken away from every encounter is that your people are the most important part of an organization. 👊🏽 “Every Dream Needs A Team” Most importantly always remember one thing when you start a new journey… find your people. Not just the ones who work with you day in & day out but the ones that dream with you & fight with you. The ones who have your back & your ear. The ones who stand with you through tough times. The ones who also see you including the parts you don’t want to be seen. The ones who never stop believing even when you do sometimes. When you find your people, you don’t just beat the world, you change it !!! #Elixir #Biotech #Clinical #Pharma #CRO #StartUp #SanDiego #DrugDevelopment #DreamBig

Exciting times in cell therapy as Bristol Myers Squibb (BMS) unveiled 18 compelling analyses at the 66th ASH Annual Meeting, spotlighting efficacy and safety in blood cancers and potential treatments for autoimmune diseases. Key highlights include: - Five-year survival data for lymphoma patients with Breyanzi showing a 38% overall survival rate ✔️ - New GPRC5D-targeted CAR T therapy, arlo-cel, for heavily pre-treated multiple myeloma patients ✔️ - Advancements in CD19 NEX-T for autoimmune diseases like lupus, hinting at revolutionary one-time treatments ✔️ BMS's positive clinical results and high manufacturing success rates highlight their dedication to transforming treatments for cancer and autoimmune diseases which is amazing to see! 🚀 #HealthInnovation #CellTherapy #Hematology #Oncology #ClinicalTrials #ClinicalResearch #LifeScienceNews #ElixirAssociates

🚨 Breakthrough in Chronic Pain Research! 🧠 Researchers at Leipzig University have unlocked new potential in chronic pain treatment by identifying hederagenin, a natural substance that blocks the NPFFR1 receptor, a key player in pain perception within the brain and spinal cord. 🧪 What makes this discovery groundbreaking? 🔹 NPFFR1's Role: A receptor critical to pain signaling, found in the spinal cord and brain regions. 🔹 Hederagenin: A natural inhibitor, identified through advanced screening and cutting-edge computer modeling. 🔹 Therapeutic Promise: This insight opens the door for innovative chronic pain treatments, showcasing the power of basic research and interdisciplinary collaboration. 👩🔬 This breakthrough was made possible by the collaborative efforts of teams from Beck-Sickinger's group, Professor Michael Schaefer, and Professor Jens Meiler's drug discovery institute. It also highlights the incredible potential of leveraging Collaborative Research Centres, like Leipzig's Structural Dynamics of GPCR Activation and Signaling. 🔑 "These findings significantly contribute to understanding NPFFR1 activation mechanisms and pave the way for future therapeutics," says Annette Beck-Sickinger 💡 Chronic pain affects millions—advances like this offer hope for transformative solutions! #Innovation #ChronicPain #Neuroscience #DrugDiscovery #Collaboration #GPCR #HealthcareBreakthrough #Hederagenin

The American Society of Hematology #ASH24 confenerce has been very productive so far in San Diego. It has been a pleasure catching up with some old friends & new potential partners as well for Elixir Associates. 🙌🏽 I’ve been super impressed by some of the positive data & posters which have been presented over the weekend. 👏🏽 It was nice to get some downtime in the evenings after doing almost 20,000 steps for the last 3 days. Got the chance to visit the world famous San Diego Zoo & also managed to watch San Diego State University vs University of San Diego #NCAA basketball game at the Viejas Arena. 🏀 #ASH24 #Hematology #Oncology #CellTherapy #SanDiego #Biotech #Pharma #CRO #Convention #Data #Clinical

In SD for @ASH24. Here at the big game for the San Diego basketball showdown, go San Diego! 😉

#ASH24 is underway! What an event! I’m here with Asad Balal meeting lots of old and new faces. We work with some of the most exciting companies here. if you’re an MD and looking for a new role, we are currently searching for; VP, Clincial Devlepment - Cell Therapy Biotech Executive Medical Director - ADC Oncology Biotech Executive Medical Director - Cell Therapy Biotech If 2025 is time for a move, let’s talk!

The global Next Generation Cancer Diagnostics (NGCD) market is poised for significant expansion 🚀 The market is set to soar from $16.6B in 2023 to $64.6B by 2030, growing at a staggering CAGR of 21.4%. Innovations like liquid biopsy, ctDNA, CTC, and miRNA testing are revolutionizing diagnostics 💰 Genomic and proteomic advancements drive personalized medicine, improving patient outcomes and minimizing side effects. NGCD technologies in hospitals, labs, and research institutes are making care more precise and effective. #OncologyResearch #CancerDiagnostics #LiquidBiopsy #PersonalisedMedicine #LifeScienceNews #ElixirAssociates

🐾 The Purr-fect Genetic Mystery Solved! 🧬 Have you ever wondered why most orange cats are boys while calico and tortoiseshell cats are girls? Me neither, but after 60 years of befuddlement, scientists have finally cracked the code behind the vibrant orange coats! 🍊 It transpires there is a fascinating mutation on the X chromosome! 🧡 Researchers discovered that a gene🧬 called Arhgap36 produces that iconic ginger hue. Even more amazing? Female cats with this mutation experience X-inactivation, creating patchwork patterns in calico and tortoiseshell cats. "Everything you need to know about genetics, you can learn from your cat," says feline geneticist Leslie Lyons. This discovery isn't just about cat coats—it's an excellent example of genetic study and trait diversity! Next time you spot an orange tabby basking in the sun, remember—there are genetic secrets underpinning their coats! 🐈 #Genetics #CatsOfInstagram #ScienceIsCool #OrangeCats #CatLovers #FelineFacts #StanfordResearch #ScienceBreakthrough