Inscopix, Inc.

𝗔 𝗰𝗼𝗹𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗶𝗼𝗻 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗜𝗻𝘀𝗰𝗼𝗽𝗶𝘅 𝗮𝗻𝗱 𝗦𝘂𝗽𝗲𝗿𝗻𝘂𝘀 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹𝘀 𝘂𝗻𝘃𝗲𝗶𝗹𝘀 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗶𝗻𝘁𝗼 𝗡𝗩-𝟱𝟭𝟯𝟴, 𝗮 𝗣𝗵𝗮𝘀𝗲-𝟮 𝗮𝗻𝘁𝗶𝗱𝗲𝗽𝗿𝗲𝘀𝘀𝗮𝗻𝘁 𝗱𝗿𝘂𝗴 𝗰𝗮𝗻𝗱𝗶𝗱𝗮𝘁𝗲. This work will be featured at the American College of Neuropsychopharmacology’s 63rd Annual Meeting in Phoenix, AZ. The poster presentation by 𝗕𝗲𝗻𝗷𝗮𝗺𝗶𝗻 𝗦𝗶𝗲𝗺𝘀𝗲𝗻, 𝗣𝗵.𝗗., will be on 𝗧𝘂𝗲𝘀𝗱𝗮𝘆, 𝗗𝗲𝗰𝗲𝗺𝗯𝗲𝗿 𝟭𝟬𝘁𝗵 𝗳𝗿𝗼𝗺 𝟱 𝘁𝗼 𝟳 𝗣𝗠 and a reception will follow. For their detailed findings and implications, visit poster 𝗧𝟭𝟯𝟳 at the ACNP Annual Meeting. #ACNP2024 #Neuroscience #Therapeutics

𝗠𝗶𝗻𝗶𝘀𝗰𝗼𝗽𝗲𝘀 𝗮𝗿𝗲 𝗮 𝗻𝗼𝘃𝗲𝗹 𝘁𝗼𝗼𝗹 𝘁𝗼 𝗲𝘅𝗽𝗹𝗼𝗿𝗲 𝗺𝗶𝗴𝗿𝗮𝗶𝗻𝗲 𝗽𝗮𝘁𝗵𝗼𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 𝗮𝗻𝗱 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰𝘀. In their recent publication, “Harnessing Miniscope Imaging in Freely Moving Animals to Unveil Migraine Pathophysiology and Validate Novel Therapeutic Strategies,” published in Synapse, researchers 𝗝𝗼𝗻𝗮𝘁𝗵𝗮𝗻 𝗭𝗮𝗽𝗮𝘁𝗮, 𝗝𝗼𝗻𝗮𝘁𝗵𝗮𝗻 𝗡𝗮𝘀𝘀𝗶, Paolo Botta, and collaborators at Lundbeck dive into how one-photon miniscopes drive the development of novel therapeutic strategies for effective migraine management. 𝗞𝗲𝘆 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗥𝗲𝘃𝗶𝗲𝘄: 1. Holistic Understanding: Integration of behavioral studies with neurovascular imaging using one-photon imaging provided a comprehensive view of migraine-related mechanisms. 2. Chronic Migraine Models: Demonstrated the potential to create chronic migraine models, paving the way for insights into long-term therapeutic interventions. 3. Dual-Color Imaging using Inscopix Miniscope: Enabled deeper exploration of the interactions between neuronal activity, neuropeptide release, and vascular responses, advancing our understanding of migraine pathophysiology. This study has important implications for future research studying other processes at play during migraines using miniscopes. Read the full publication here: https://hubs.ly/Q02-9gDn0 #neuroscience #migraine #therapeutics

A Big Congratulations to Dr. Biafra Ahanonu, Dr. Andrew Crowther, and the team from Professor Allan Basbaum lab at University of California, San Francisco on their Nature Methods publication! Their research has overcome significant challenges in 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 𝐬𝐩𝐢𝐧𝐚𝐥 𝐜𝐨𝐫𝐝 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲, enabling 𝐥𝐨𝐧𝐠-𝐭𝐞𝐫𝐦 𝐨𝐩𝐭𝐢𝐜𝐚𝐥 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 in freely moving animals 𝐊𝐞𝐲 𝐀𝐝𝐯𝐚𝐧𝐜𝐞𝐦𝐞𝐧𝐭𝐬: ✅Development of a cost-effective spinal imaging chamber combined with multi-step surgical procedures, ensuring stability and long-term functionality. ✅ A 𝐰𝐢𝐝𝐞 𝐟𝐢𝐞𝐥𝐝 𝐨𝐟 𝐯𝐢𝐞𝐰 using Inscopix nVue Lscape Module for bilateral imaging, visualizing activity across both sides of the spinal cord. ✅ 𝐧𝐕𝐮𝐞 𝐃𝐮𝐚𝐥-𝐜𝐨𝐥𝐨𝐫 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 capabilities to monitor both neural dynamics and microglial changes in real time. ✅ Real-time tracking of 𝐩𝐚𝐢𝐧 𝐩𝐫𝐨𝐜𝐞𝐬𝐬𝐢𝐧𝐠, 𝐧𝐞𝐫𝐯𝐞 𝐢𝐧𝐣𝐮𝐫𝐲 𝐫𝐞𝐬𝐩𝐨𝐧𝐬𝐞𝐬, and 𝐦𝐢𝐜𝐫𝐨𝐠𝐥𝐢𝐚𝐥 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲, providing critical insights into chronic pain mechanisms and spinal cord physiology. ✅ Long-term imaging in freely moving animals, enabling coupling neural activity with behavior to unlock new discoveries in spinal cord research. Discover how this breakthrough is transforming spinal cord research and unlocking new insights into chronic pain, nerve injury, and neurological disorders ➡️Read the publication: https://hubs.ly/Q02Ynkvq0 ➡️Watch the webinar: https://hubs.ly/Q02YnCFn0

Can’t believe #SfN24 was almost a month ago! We’re still buzzing from the fascinating conversations and innovations in neuroscience we encountered. 🧠 If you missed the action or want to relive it, check out our #SfN2024 recap by Bruker Life Science Writer 𝗠𝗲𝗹𝗶𝘀𝘀𝗮 𝗠𝗮𝗿𝘁𝗶𝗻, where she captures the energy and insights that made this year unforgettable! https://hubs.ly/Q02XdmdH0

Ever wondered what drives an aggressive state in the brain? 𝗚𝗲𝗼𝗿𝗴𝗲 𝗠𝗼𝘂𝗻𝘁𝗼𝘂𝗳𝗮𝗿𝗶𝘀 et al. from 𝗗𝗮𝘃𝗶𝗱 𝗝. 𝗔𝗻𝗱𝗲𝗿𝘀𝗼𝗻's lab at Caltech has some fascinating answers! Published in Cell, this study uncovers how neuropeptide signaling in the hypothalamus shapes aggression. 𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀: ✔️This work shows that 𝗼𝘅𝘆𝘁𝗼𝗰𝗶𝗻 and 𝘃𝗮𝘀𝗼𝗽𝗿𝗲𝘀𝘀𝗶𝗻 𝗿𝗲𝗰𝗲𝗽𝘁𝗼𝗿𝘀 in the VMH encodes a sustained state of aggression. ✔️Employing "𝗖𝗥𝗜𝗦𝗣𝗥𝗼𝘀𝗰𝗼𝗽𝘆," which combines CRISPR gene editing and 𝘀𝗶𝗻𝗴𝗹𝗲-𝗰𝗲𝗹𝗹 𝗰𝗮𝗹𝗰𝗶𝘂𝗺 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 with #𝗻𝗩𝗶𝘀𝘁𝗮, the study pinpointed how disrupting neuropeptide receptors reduces aggressive behavior without altering other social responses. ✔️The study highlights unique "𝗹𝗶𝗻𝗲 𝗮𝘁𝘁𝗿𝗮𝗰𝘁𝗼𝗿 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀," where neural circuits actively maintain internal states like aggression, driven by neuropeptide signaling. This research is a leap toward understanding how internal states are encoded and maintained in the brain! ➡️ https://hubs.ly/Q02WFgMr0

🌐Register for our New Horizons webinar with Dr. Matsuda from Gifu University as he presents his #nVoke optogenetics & imaging research. Gain valuable insights into essential fluid regulation of salt & water, crucial appetitive processes. Secure your spot! https://hubs.ly/Q02VHk000

🚨 New Insights into 𝗦𝗼𝗰𝗶𝗮𝗹 𝗙𝗲𝗮𝗿 𝗣𝗿𝗼𝗰𝗲𝘀𝘀𝗶𝗻𝗴 from Columbia's Mortimer B. Zuckerman Mind Brain Behavior Institute! Pegah Kassraian and the team from Dr. Steven A. Siegelbaum lab at Columbia University have uncovered new insights into how the hippocampus processes social fear. By employing advanced techniques such as 𝘀𝗶𝗻𝗴𝗹𝗲-𝗰𝗲𝗹𝗹 𝗰𝗮𝗹𝗰𝗶𝘂𝗺 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝘄𝗶𝘁𝗵 𝗜𝗻𝘀𝗰𝗼𝗽𝗶𝘅'𝘀 #𝗻𝗩𝗶𝘀𝘁𝗮, they revealed the critical roles of the CA2 and CA1 regions in distinguishing social threats from safety. Their study, published in 𝗡𝗮𝘁𝘂𝗿𝗲 𝗡𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲, reveals that: 𝗗𝗶𝘀𝘁𝗶𝗻𝗰𝘁 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝘀: 🧠𝗖𝗔𝟮 distinguishes between safe and threatening social interactions. 🧠𝗖𝗔𝟭 encodes the locations tied to these experiences. 𝗘𝘅𝗽𝗲𝗿𝗶𝗺𝗲𝗻𝘁 𝗿𝗲𝘀𝘂𝗹𝘁𝘀: Mice learned to avoid a "risky" stranger associated with a mild shock. ✳️𝗦𝗶𝗹𝗲𝗻𝗰𝗶𝗻𝗴 𝗖𝗔𝟭 caused mice to forget the shock location. 🐁𝗦𝗶𝗹𝗲𝗻𝗰𝗶𝗻𝗴 𝗖𝗔𝟮 made mice fearful of both strangers—pointing to a connection with generalized social avoidance, a core feature of social anxiety and related disorders. 💡These findings highlight 𝗖𝗔𝟮’𝘀 𝗿𝗼𝗹𝗲 in regulating 𝘀𝗼𝗰𝗶𝗮𝗹 𝗳𝗲𝗮𝗿 𝗺𝗲𝗺𝗼𝗿𝘆, a process vital for survival, opening new paths for understanding conditions like PTSD and social anxiety. Fantastic Research. Read for more insight 🡪 https://hubs.ly/Q02VS-3j0

🌐Join our New Horizons webinar with the esteemed Dr. Takashi Matsuda from Gifu University as he shares his latest insights using optogenetic manipulation and calcium imaging with the #nVoke system. Discover how the brain monitors body fluids like salt & water - critical appetitive processes! Register here to learn more👇https://hubs.ly/Q02VHp_b0

🧠🔬 The 𝗜𝗻𝘀𝗰𝗼𝗽𝗶𝘅 𝗗𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆 𝗟𝗮𝗯 showcased a wide range of groundbreaking research at #SfN24, and now you can access it all! From 𝗺𝗶𝗻𝗶𝘀𝗰𝗼𝗽𝗲-𝗯𝗮𝘀𝗲𝗱 𝗯𝗹𝗼𝗼𝗱 𝘃𝗲𝘀𝘀𝗲𝗹 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 for migraine therapeutics to 𝗻𝗲𝘂𝗿𝗼𝗯𝗲𝗵𝗮𝘃𝗶𝗼𝗿𝗮𝗹 𝗽𝗿𝗼𝗳𝗶𝗹𝗶𝗻𝗴 for antidepressants and antipsychotics, their posters cover key advancements in neuroscience drug development and therapeutic assessment. You can now download these presentations and explore the details on our 𝗻𝗲𝘄 𝘄𝗲𝗯𝘀𝗶𝘁𝗲, including information about their 𝗖𝗥𝗢 𝘀𝗲𝗿𝘃𝗶𝗰𝗲𝘀 advancing preclinical research! Check it out here ➡️ https://hubs.ly/Q02TsXtd0 #CROServices #Preclinical #Neuroscience #DrugDevelopment #InscopixDiscoveryLab

🌍 Today is 𝗪𝗼𝗿𝗹𝗱 𝗠𝗲𝗻𝘁𝗮𝗹 𝗛𝗲𝗮𝗹𝘁𝗵 𝗗𝗮𝘆, and this year’s theme, "𝗠𝗲𝗻𝘁𝗮𝗹 𝗛𝗲𝗮𝗹𝘁𝗵 𝗮𝘁 𝗪𝗼𝗿𝗸" reminds us of the power of understanding the brain and its impact on our well-being. Let’s continue to push boundaries in neuroscience while creating workplace cultures that value mental health. A healthy mind leads to groundbreaking ideas and discoveries.