Inside Precision Medicine

100,000 Genomes Study Identifies 141 Novel Disease-Gene Associations Several associations were backed by existing experimental evidence, including links between genes and monogenic diabetes, schizophrenia, and epilepsy. Queen Mary University of London UCL #genome #diabetes #schizophrenia #epilepsy

AI Accelerates Discovery of Genes Linked to Neurodevelopmental Disorders Researchers, led by a team from Baylor College of Medicine, demonstrate that models trained solely on single-cell RNA sequencing data can robustly predict genes implicated in #autism spectrum disorder, developmental and epileptic encephalopathy, and developmental delay.

Wartime Trauma Holds Genetic Legacy A study of Syrian refugees has shown that wartime violence experienced by women during pregnancy can be passed on to future generations. The findings have important implications for understanding the inheritance of trauma and highlight the critical period of in utero development, the researchers said.

Novel Antibody-Toxin Conjugate Prompts Immune System to Eliminate Tumors The MD Anderson Cancer Center new class of drug could overcome the resistance developed by the traditional design of antibody-drug conjugates (ADCs) to provide more durable treatment responses. #DrugDiscovery #cancer #immunotherapy

Continuous Glucose Monitors Overestimate Blood Sugar Levels for Certain Foods For diabetics, the use of CGMs remains critical since the devices provide real-time glucose monitoring and for healthy individuals, relying on CGMs could lead to unnecessary food restrictions or poor dietary choices. University of Bath #diabetes

One in Six Phase II Trial Participants Receive Cancer Drugs that Advance to Approval What the McGill University study says is for every six patients who enter a Phase II trial, one will get a drug that is eventually FDA approved for their condition and a lot of patients would view that as favorable odds.

Alzheimer’s Study Finds 16 New Gene Variant Locations Adding people of non-White ancestry to a study assessing the genetics of #Alzheimer's led to the identification of 16 new areas of variation. Massachusetts General Hospital researchers led the study.

AI-Powered ECG Model Exposes Hidden Cardiovascular Risks in Women The model introduces a novel biomarker, the "sex discordance score," which highlights elevated risks of heart disease and related conditions in women. Imperial College London #ArtificialIntelligence #HeartDisease

FDA Approves Personalized Brain Stimulation Device for Parkinson’s Medtronic says it is the only company in the world to offer an adaptive DBS system that dynamically adjusts therapy in real time. #parkinsons #brain Brett Wall

Eli Lilly and Company and Olix Ink $630M for Deal Early-Stage MASH Candidate OliX Pharmaceuticals, Inc.'s focus is down-regulating the expression of disease-causing genes based on its proprietary RNAi technology.