InsightRX

A new study evaluates the relationship between vancomycin supratherapeutic dosing and acute kidney injury (AKI) through a novel correlation factor equation within an antimicrobial stewardship program. The key takeaway is that all AKIs were in courses that had AUC<600, so pharmacists should continue to monitor for other sources of AKI. Yazan S. Batarseh, Department of Pharmacy, Holyoke Medical Center Published in Journal of Pharmaceutical Research International. https://hubs.ly/Q030x4nh0 | #Vancomycin #SupratherapeuticDosing #AcuteKidneyInjury #AntimicrobialStewardship

Age is a convenient surrogate for health, wellness, environmental exposures, and life experiences. Defining a physiological age has appeal because it could provide a better individual-specific measure of health status than chronological age. The goal of this study was to leverage ensemble learning approaches to develop physiological aging measures from point-of-care biomarkers. Published in CPT: Pharmacometrics & Systems Pharmacology. ➡ https://hubs.ly/Q030lz-w0 | #PhysiologicalAge #Biomarkers #PrecisionMedicine #PrecisionDosing

Addressing the challenges of rare and neglected diseases requires a united effort across multiple disciplines. In this editorial, scientists call upon the clinical pharmacology and translational science community to collaborate across sectors and disciplines to be able to collectively transform the landscape of rare and neglected diseases, offering hope to millions of patients worldwide. Published in Clinical Pharmacology & Therapeutics. https://hubs.ly/Q0302x1j0 | #ClinicalPharmacology #RareDiseases #ClinicalResearch #DrugDevelopment

In this episode of the Oncology Unplugged series, Chandler Park, M.D., F.A.C.P., a genitourinary medical oncologist at Norton Healthcare Cancer Institute in Louisville, Kentucky, hosted a conversation with Vivek Subbiah, MD, a medical oncologist and chief of Early-Phase Drug Development at Sarah Cannon Research Institute in Nashville, Tennessee. Dr. Subbiah, an internationally recognized expert, discussed advancements in precision oncology, emphasizing the effects of next-generation sequencing and tissue-agnostic therapies on personalized cancer treatment. Learn more via OncLive: https://hubs.ly/Q02_NMbn0 | #PrecisionMedicine #PrecisionOncology #PersonalizedMedicine MJH Life Sciences®

A new study demonstrates that the selection of an appropriate adult reference population is important for pediatric PK exposure matching and pediatric dose selection, especially for a drug that is substantially eliminated through renal excretion. The findings are useful for the extrapolation of the efficacy of other drugs from adult to pediatric populations. Published in CPT: Pharmacometrics & Systems Pharmacology. https://hubs.ly/Q02_CTkK0 | #PK #Pharmacokinetics #PopPK #Pharmacodynamics

A new study concluded that following the implementation of a pharmacist-driven AUC monitoring program, patients were less likely to develop nephrotoxicity during outpatient vancomycin therapy. Published in Open Forum Infectious Diseases. https://hubs.ly/Q02_hD7Z0 | #PrecisionMedicine #Vancomycin #AntimicrobialTherapy Eric Gillett Brigham and Women's Hospital

A new study aimed to identify the optimal PK/PD predictor and assess the correlation between AUC/MIC, trough concentration and the vancomycin efficacy in neonates. Published in Journal of Antimicrobial Chemotherapy. https://hubs.ly/Q02-YSbc0 | #PrecisionMedicine #Vancomycin #Pharmacokinetics #Pharmacodynamics #PKPD

Our very own Stephanie Hughes, PharmD, BCIDP, joins Michael Rybak, PharmD, MPH, PhD, for this informative episode of the American College of Clinical Pharmacy (ACCP) Journal Podcast. Hughes shares information about her recent publication, “Impacts of age and BMI on vancomycin model choice in a Bayesian software: Lessons from a very large multi-site retrospective study” which was recently published in Pharmacotherapy. Over 380K vancomycin treatment courses were used to evaluate the predictive performance of various vancomycin PK models across diverse age and BMI categories. Learn how to apply these findings to your patient. Listen to the ACCP Journal Podcast now: https://hubs.ly/Q02-L2ny0 Listen on Spotify: https://hubs.ly/Q02-L2g30 Listen on Apple Podcasts: https://hubs.ly/Q02-KZZ-0 Full text of the Open Access manuscript is available here: https://hubs.ly/Q02-L0G20 | #PrecisionMedicine #Vancomycin #Bayesian #InsightRX

We’re pleased to announce that we will be presenting a research abstract at the ASHP2024 Midyear Clinical Meeting & Exhibition scheduled for Dec. 8-12 at the Ernest N. Morial Convention Center in New Orleans. POSTER PRESENTATION Proposed Update to the Cockcroft-Gault Equation for Patients with Low Serum Creatinine: Results from a Massive Multi-Site Dataset 📆 Monday, December 9, 2024 🕑 2-3:30 p.m. 🎙 Jon Faldasz, PharmD, BCPS, Senior Director of Product & Customer Experience, InsightRX “InsightRX has enjoyed a year of real growth and accomplishment and we’re excited to meet with our colleagues at ASHP in New Orleans to discuss what we’ve learned and how we plan to continue improving dosing safety and accuracy,” said Sirj Goswami, PhD, CEO and cofounder of InsightRX. “Model-informed precision dosing holds great promise for contributing to better clinical outcomes and operational efficiency.” Learn more and plan to join us on Monday: https://hubs.ly/Q02-99Sx0 | #PrecisionMedicine #PrecisionDosing #CockcroftGaultEquation #PKPD #TherapeuticDosage

A new study dives into the predictive power of GFR-based scaling models, comparing them to the Mech-KiM model using a PBPK modeling approach. It uses hypothetical drugs with varying degrees of passive tubular reabsorption and the model drug metronidazole, known for its 96% fractional tubular reabsorption. Check it out in CPT: Pharmacometrics & Systems Pharmacology: https://hubs.ly/Q02Z_ScD0 #Pharmacometircs #Pharmacology #Pharmacokinetics #PBPK