Institute for In Vitro Sciences, Inc.

We are happy to share a recent publication "A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods" (Sadekar, Behrsing, et al., 2025). This multi-lab collaboration with Research Institute for Fragrance Materials, Inc. (RIFM), highlights how New Approach Methodologies (NAMs) are used for the safety evaluation of inhalation exposure to chemicals and products.

As we begin the year, IIVS invites you to consider becoming a supporter of our work. Our scientists work in the Washington, DC area and around the world to promote good in vitro science and to facilitate the use of non-animal methods for regulatory toxicology across chemical, pesticide, medical device, and personal care sectors. Our Education and Outreach trainings, workshops, expert comments, and guideline development are having an impact and we couldn't do it without consistent support from our contributors to cover our time, travel, and other expenses. Find out more about how you can work with us and support our work by emailing ksullivan@iivs.org or visiting our web site.

Join us later this month to learn more about assessing systemic toxicity using non-animal approaches.

🗓️ Save the Date! Join us in June 2025 for a workshop focused on inhalation techniques for liquid and dry powder aerosols at the air liquid interface. It will be held at our headquarters in Gaithersburg and is co-organized by Vitrocell Systems GmbH and supported by AlveoliX . Hope you will be able to join us!

IIVS wishes all our sponsors, supporters, colleagues, and contributors an enjoyable holiday season!   Please note that we will be closed and unable to receive test materials between December 24th and January 1st. Additionally, IIVS will be unable to perform studies requiring human reconstructed epidermal or epithelial tissues during this week and the week of January 6th.

Save the date for a workshop next June 26-27 for a collaboration with Vitrocell Systems GmbH and AlveoliX !

Last week IIVS's Kristie Sullivan was invited to speak at the 4th Indian Congress on Alternatives to Animal Experiments. Her talk focused on the themes of the meeting--validation and regulatory acceptance--and how to adapt these important process, as well as how to engage regulators with supportive outreach, in order to facilitate more efficient use and acceptance of non-animal methods. The visit afforded an opportunity to meet with regulators and scientists from across India. We look forward to continued collaborations in 2025!

📢 For our Spanish-speaking Colleagues: Join us this Wednesday for the third webinar in the series “Updates on New Approach Methodologies (NAMs) Applied to Human and Environmental Safety", presented by the International Collaboration on Cosmetics Safety in collaboration with Universidad Federal de Goiás (FF/UFG) and Laboratório de Ensino e Pesquisa em Toxicologia In Vitro - Tox In. 🗓 Date: December 18, 2024 🕑 Time: 14:00 Brasília / 11:00 Mexico City / 10:00 Bogota 🌍 Language: Spanish Speakers: 🎤 Nicole Kleinstreuer (NICEATM, NIEHS): “(R)evolution in Validation” 🎤 María Laura Gutiérrez (UBA/CONICET): “Advances in Ocular Toxicity: Implementation of Validated Methods and Development of Innovative Approaches” Moderated by Argel Islas-Robles (Institute for In Vitro Sciences, Inc.). 📩 Register for free here: https://lnkd.in/epjKckKP #ICCS #UFG #LATAM #NAMs #NGRA #Toxicology #Cosmetics #invitro

Announcing! The next EPIC webinar will be January 29th, 2025 and focus on the development of non-animal systemic toxicity approaches for regulatory applications and feature Dr. Katie Paul Friedman of the US Environmental Protection Agency (EPA) and Dr. Elisabet Berggren from the European Commission Joint Research Centre. ICYMI: You can also get the recording from the webinar earlier this week featuring Rachel Brunner, PhD, Dr. Donna Macmillan, and Dr. Emily Reinke discussing recent updates in skin sensitization approaches for regulatory use. Register for the January webinar and see the recording from December here: https://lnkd.in/dTWXTDwv.

🚨 You are invited to publish: Special Issue on Skin Sensitization NAMs 🚨 We are excited to announce that IIVS' Toxicologists, Gertrude-Emilia Costin Ph.D., M.B.A., ATS, ERT & Argel Islas-Robles Ph.D., are serving as Guest Editors for an upcoming Special Issue of Toxics MDPI. The aim of this Special Issue is to explore how NAMs are applied practically, both for regulatory submissions and internal decision-making processes, and to highlight emerging methodologies and global regulatory perspectives. Invited contributions include: ✅ Original research papers ✅ Review articles ✅ Short communications ✅ Regulatory position articles Topics of interest include (but are not limited to): 🔬 Skin sensitization assessment via non-animal methods 🔬 Defined approaches and adverse outcome pathways, including computational analysis 🔬 Use of NAMs for particular product classes: cosmetics, medical/wearable devices, mixtures, botanicals, agrochemicals, etc. 🔬 Comparative analysis of regulatory acceptance across industries 📅 Manuscript Submission Deadline: 31 December 2025 💻 Information and Submission site: https://lnkd.in/eHyyiHtc #Invitro #toxicology #NAMs #SkinSensitization #Toxics #CallForPapers