Maddie BioGenetics

Go Team! Thanks Plug and Play Tech Center and Plug and Play Friday Pitch Session for giving us the opportunity!

Come out and see Gavenraj Singh Sodhi, CEO of Maddie BioGenetics "MaddieBio" and meet Maddie, herself in person who is Gavenraj's driving force and inspiration to make whole genome testing affordable, accessible and understandable as we continue developing our platform to repurpose existing drugs and therapies for curing rare diseases, starting with Rett Syndrome. Have someone impacted by a rare disease, having a driving force for your inspiration, let's start a conversation, let's work together for a cure. see you there next week. Maddie BioGenetics #raredisease #rettsyndrome UC San Diego HomeLab™ at UC San Diego #Bio2024 #June4

Come out and see Gavenraj Singh Sodhi, CEO of Maddie BioGenetics "MaddieBio" and meet Maddie, herself in person who is Gavenraj's driving force and inspiration to make whole genome testing affordable, accessible and understandable as we continue developing our platform to repurpose existing drugs and therapies for curing rare diseases, starting with Rett Syndrome. Have someone impacted by a rare disease, having a driving force for your inspiration, let's start a conversation, let's work together for a cure. see you there next week. Maddie BioGenetics #raredisease #rettsyndrome UC San Diego HomeLab™ at UC San Diego #Bio2024 #June4

FDA approval of a new gene therapy for children with metachromatic leukodystrophy (MLD), a rare and fatal genetic disease of the nervous system. There is currently no cure for MLD, but this new gene therapy, called Lenmeldy, has been shown to be effective in treating children. Lenmeldy is made from a patient's own stem cells and is designed to introduce a functional copy of the ARSA gene into the patient's cells. This can help stop the progression of MLD. https://lnkd.in/epcpJtrT #genetherapy #stemcell #raredisease #pediatrics Follow-us as we cover rare disease and cancer advances - Maddie BioGenetics

The All of Us Research Program is a landmark initiative by The National Institutes of Health to collect health data from one million or more people in the U.S. to advance precision medicine. By considering individual differences in genetics, environment, and lifestyle, the program aims to uncover tailored healthcare approaches and improve health outcomes, particularly for underrepresented groups in biomedical research. Genetic diversity in research is crucial because it allows for a more comprehensive understanding of human genetics across different populations. This inclusivity leads to better disease risk assessments, more effective treatments, and the development of precision medicine that is representative of global diversity. Positive Impact here at Maddie BioGenetics: Increased demand: Growing awareness of genetic diversity and its impact on health could increase demand for personalized genetic testing services. Improved accuracy: Access to a wider range of genetic data (like Allofus') can improve the accuracy of AI models used for interpreting test results and recommending personalized health measures. Stronger value proposition: Highlighting the importance of diverse genetic data for personalized medicine strengthens the value proposition, especially for underrepresented communities. Positive impact on the genetics community: Enhanced research: Allofus' findings provide valuable data for researchers, leading to a better understanding of genetic variations and their influence on health across diverse populations. More inclusive healthcare: Increased understanding of genetic diversity can lead to the development of more inclusive medical treatments and prevention strategies that cater to the specific needs of different populations. Advancement of precision medicine: Diverse genetic data is crucial for the advancement of precision medicine, allowing for more accurate disease risk assessments and personalized treatment plans. #MaddieBioGenetics #PersonalizedCareForAll #genetictesting #genetics #gratefuleveryday #artificialintelligence #largelanguagemodel https://lnkd.in/g-6fgd9d

At Maddie BioGenetics, we look at clinically validated approaches with the integration of modern advancements from the use of AI/ML and Large Language Models (LLM). Stepping outside our immediate zone of comfort, we can embrace into reality the advances of AI/ML and LLM applying to Genetic Editing in ways that will continue to evolve therapeutic strategies: 1) Target Identification: Utilizing AI/ML algorithms to analyze vast datasets of genetic information and identify potential targets for Prime Editing interventions. This can accelerate research and development by pinpointing the most promising candidates for therapeutic editing. 2) Data-Driven Modeling: Employing AI/ML to predict the potential outcomes of Prime Editing in various scenarios, optimizing the technique for efficacy and safety. This can help guide researchers towards the most effective editing strategies. 3) Personalized Medicine: Leveraging LLMs to interpret individual genetic profiles and tailor Prime Editing approaches to specific patient needs. This can pave the way for personalized treatments with higher success rates and fewer side effects. 4) In Silico Simulation: Utilizing AI/ML to simulate and test potential Prime Editing strategies in a virtual environment before applying them to real patients. This can reduce risks and refine the editing process for greater effectiveness. 5) Drug Discovery: Employing AI/ML to discover and design new molecules that can enhance the efficiency and accuracy of Prime Editing techniques. This can accelerate the development of improved gene editing tools. https://lnkd.in/g_VJdNgY Maddie BioGenetics #digitalhealth #transformation #genetics #biogenetics #PersonalizedCareForAll #EmpoweringThroughScience

Generative AI will help apply biogenetics to create novel and realistic biological artifacts, such as synthetic DNA, proteins, cells, or organs. Generative AI will be used to design, optimize, and test new biogenetic products or solutions. For example, one will be able to use generative AI to create synthetic DNA sequences that can be used for gene editing, gene therapy, or biomanufacturing. One can also use generative AI to generate protein structures that can be used for drug discovery, vaccine development, or biomaterials. Alongside the topics covered at the JP Morgan Healthcare conference, 2024 will be an amazing time for Genetics and overall digital health. Maddie BioGenetics #digitalhealth #transformation #genetics #biogenetics #jpm2024 #biopharma

Please join our Founder and CEO, Gavenraj Singh Sodhi, as he will be presenting "Empowering Individuals Through AI: Understanding Health and Genetic Predispositions" as part of the Spring Development Days for 2024 at Austin Community College this Friday, January 12th, at 3:30 pm CT. Join me this Friday as we launch a series of webinars and workshops with industry leaders, educators, scientists, and our neighbors, like you and me, to get informed on the advances coming our way today. You can find my session link at the bottom of the following page: https://lnkd.in/gJ--WBiT Maddie BioGenetics #genetics #empowerment #selfcare

Choosing the top 5 conferences out of the many exciting events happening in 2024 is tough, but here are some of the most prestigious and impactful ones to consider: The Human Genome Meeting (HGM): This premier annual conference, happening from October 8-12, 2024, in Boston, USA, brings together leading scientists and researchers from around the world to discuss the latest advances in human genetics and genomics. It covers a wide range of topics, from basic research to clinical applications, and features keynote presentations, poster sessions, workshops, and networking opportunities. www.hugo-international.org Human Genome Meeting (HGM) World Human Genetics Congress (WHGC): This biennial event, taking place from September 8-12, 2024, in Toronto, Canada, is another major gathering for human genetics researchers. It focuses on the latest discoveries and developments in the field, with a particular emphasis on translational research and its impact on human health. The WHGC is known for its high-quality scientific program and its vibrant atmosphere. https://lnkd.in/giRS-3En World Human Genetics Congress (WHGC) European Society of Human Genetics (ESHG): The ESHG annual conference is a key event for the European human genetics community. It will be held from May 26-30, 2024, in Copenhagen, Denmark, and will cover a broad range of topics, including population genetics, medical genetics, and genetic counseling. The ESHG conference is a great opportunity to learn about the latest research from Europe and to network with colleagues from across the continent. www.dnaday.eu European Society of Human Genetics (ESHG) American Society of Human Genetics (ASHG): The ASHG annual meeting is the largest human genetics conference in North America. It will be held from October 26-30, 2024, in Baltimore, USA, and will feature presentations on all aspects of human genetics and genomics. The ASHG meeting is a must-attend for anyone who wants to stay up-to-date on the latest advances in the field. www.ashg.org American Society of Human Genetics (ASHG) Asia Pacific Conference on Human Genetics (APCHG): The APCHG is a regional conference that brings together human genetics researchers from across Asia and the Pacific Rim. It will be held from November 11-14, 2024, in Shanghai, China, and will focus on the latest research on human genetics and genomics in the region. The APCHG is a great opportunity to learn about the unique challenges and opportunities facing human genetics in Asia and to network with colleagues from the region. https://lnkd.in/g_hggeG5

At Maddie BioGenetics, we're not just rewriting the script for genetic testing, but for the entire healthcare journey. We're about unlocking the power of personalized care for families facing genetic dispositions, childhood cancer, epilepsy, and countless other challenges. Maddie, my daughter, taught me the true cost of inaccessible answers. Misdiagnosis, seizures, open heart surgery (at 16 months old) – our fight became a mission for every family like ours, drowning in the ocean of uncertainty. But hope isn't enough. We need action, not tomorrow, but today. That's why we go beyond genetic testing. We're building a bridge to personalized care, paving the way for families to access the right drugs, gene therapies, and treatment plans tailored to their unique genetic blueprint. No more one-size-fits-all approaches. No more "nothing left to do." Our team, a vibrant tapestry of experts, fuels this mission with their passion and expertise. We've seen the fear etched on parents' faces, the relief flooding their eyes when knowledge unlocks possibilities. For countless families, "nothing left to do" will be transformed into a roadmap for action, a chance to rewrite their story. 2024 marks our turning point. We'll unveil our solution, a beacon of hope proving that "impossible" is just a whisper in the face of innovation. We'll embrace challenges and celebrate victories, hand in hand with our community. Genetics might be new, but our passion is ancient. Join us on this journey. Partner with us, follow our story and witness the dawn of a new era where knowledge empowers, not isolates, and where personalized care becomes the standard, not the exception. This isn't just about Maddie. It's about all of us. Together, we'll rewrite the script for a healthier future, one personalized treatment plan at a time. #MaddieBioGenetics #PersonalizedCareForAll #EmpoweringThroughScience #Onward Maddie BioGenetics