Metrum Research Group

📢 New Publication Alert 📢 How should we prioritize research spending in major depressive disorder (MDD)? What role do placebo effects play in clinical trials, and how hard should we work to remove them? In a new correspondence published in Translational Psychiatry, James Rogers (MetrumRG) and Stephen Senn (Statistical Consultant) dive into these critical questions, offering statistical insights that can shape the future of MDD research. Read more: https://lnkd.in/gRyzueSB #Pharmacometrics #ClinicalTrials #Biostatistics #MDD

🚀 Join Our Mission at Metrum Research Group! 🚀 We’re looking for a Client Relationship Coordinator (CRC) to be part of our world-class team transforming biomedical decision-making. If you’re passionate about learning, collaboration, and driving impact at the intersection of data, science, and technology, we want to hear from you! As a CRC, you’ll work closely with sales, business development, and product teams to ensure a seamless experience for our customers—from initial engagement to long-term success. 🔹 Strong communication & relationship-building skills 🔹 Experience in sales operations & data analysis 🔹 Comfort with scientific & technological topics Join us in improving health and defeating disease where unmet needs exist. Apply today! ps://https://lnkd.in/gt95sQ4f #Hiring #ClientRelations #SalesOperations #Biotech #LifeSciences

🌟 Join Our Team at Metrum Research Group 🌟 We’re seeking a PKPD Modeling and Simulation Group Leader, Principal Scientist to lead a talented team and drive impactful drug development. At MetrumRG, we’re passionate about learning, sharing knowledge, and improving health for all. In this role, you’ll mentor scientists, collaborate on model-informed strategies, and contribute to advancing biomedical decision-making. What we’re looking for: ✔ 10+ years of experience in modeling and simulation. ✔ Ph.D. or equivalent in a related field. ✔ Expertise in tools like NONMEM, MONOLIX, or STAN. ✔ Proven leadership and mentoring skills. Ready to make a difference? Apply now: https://lnkd.in/gkt4ztvU #JoinOurTeam #BiomedicalScience #DrugDevelopment #CareerOpportunity

❄️ Fresh updates for the new year – our Winter Newsletter is here! 📢 Highlights include: • Introducing Strategic Advisory Solutions, our newest offering to enhance decision-making in drug development. • Welcoming Dr. Brian Corrigan to lead this exciting initiative. • A deep dive into Bayesian workflows on our latest podcast. • Explore MeRGE Expo 4: Bayesian population PK analysis using Stan/Torsten. • Recent research breakthroughs and employee news. Stay informed and connected – click here to subscribe: https://lnkd.in/gzZF8_-w #MetrumRG #Pharmacometrics #ModelingAndSimulation #MIDD

Join us in our mission! Metrum Research Group is seeking an Applied Data Scientist who will play a vital role in the programmatic application of data processing, analysis, and reporting methods to support scientific insights. Click to learn more and apply: https://lnkd.in/gyTuhNyx #Metrumrg #NewRole #Hiring #AppliedDataScientist #Apply

🎙️ New Podcast Alert: Exploring Bayesian Workflow Dive into the influential 2020 manuscript,  Bayesian Workflow, with MetrumRG! In our latest podcast episode, VP of Statistics James Rogers leads a dynamic discussion featuring two of the paper's co-authors: 🔹 Andrew Gelman – Professor of Statistics & Political Science at Columbia University 🔹 Charles Margossian – Research Fellow at the Flatiron Institute and former MetrumRG Visiting Scientist Learn why workflow is the critical link connecting theory and practice, why it is essential to set multiple models in dialogue with each other for any given scientific problem, and why the authors see “model navigation as the next transformative step in data science." 🎧 Listen now: https://lnkd.in/gAs5rPkP and check out the open-access paper here: https://lnkd.in/d99uWfU8 As discussed in the interview, MetrumRG’s approach to workflow is embodied in our open source MeRGE ecosystem. Check out our  freely available MeRGE Expos. #OpenScience #BayesianStatistics #Pharmacometrics #MetrumRG

Metworx is transforming quantitative analyses in drug development. 🌟 ✅ Built by scientists, for scientists ✅ Cloud-based modeling, simulation, and decision informatics platform ✅ Seamless integration with industry-leading software and exclusive tools from Metrum Research Group Reduce risks, streamline workflows, and achieve reproducible, traceable results faster. Ready to revolutionize your approach?  Contact us: https://lnkd.in/gq-GxBBg 🔗 https://lnkd.in/gAiAFJ_M (this should be the embedded video in the post)  #Metworx #ModelingAndSimulation #Pharmacometrics #DrugDevelopment

🎉 Meet Seth Green, Manager of Data Science Engineering at MetrumRG! 🎶 From touring musician to data science leader, Seth thrives at the intersection of technology and science. Discover his journey, passions, and his role in shaping the future at MetrumRG! 👉 Read the Spotlight: https://lnkd.in/gC4SEUYc #EmployeeSpotlight #MetrumRG #DataScience

What an incredible #ACoP2024! 🌟 Connecting with our clients and friends (old and new) in the pharmacometrics community made this year very special. We are energized by the many conversations around sessions, posters, and casual visits to our exhibit booth. A special thank you to those who attended our Bayesian workshop and our Metworx Users Group (MUG) breakfast.    Huge thanks to the organizers for another fantastic ACoP! Looking forward to 2025! 👏   #Pharmacometrics #ModelInformedDrugDevelopment #ISoP #MetrumRG

Today is  the last day for poster presentations at ACoP 2024! MetrumRG scientists will be presenting the following: - Data Gaps, Model Mishaps: Quantifying the Impact of Missing Pharmacometrics Data on Pharmacodynamic Projections. Rena Byrne, Ph.D.; Hillary Husband, Ph.D.; Megan Cala Pane, Ph.D.; Curtis Johnston, Pharm.D. W-011 - Gompertz Cure Rate Survival Models with Stan and brms. Todd Yoder, Ph.D.; Andrew Tredennick, Ph.D.; Timothy Waterhouse, Ph.D. W-136 - Longitudinal Joint Modeling of Modified Mayo Score and Dropout in Patients with Moderate to Severely Active Ulcerative Colitis. Timothy Waterhouse, Ph.D.; Mike Heathman M.S. (contributing). W-032 - Losing the Forest: Causal Shapley Values for interpretation of Population-Pharmacometric Models. Matthew Wiens, M.S.; Elias Clark, Ph.D.; Curtis Johnston, Pharm.D. W-133 - pmparams: an R Package for Defining and Formatting Parameter Tables in Pharmacometric Modeling. Grace O’Brien, Ph.D.; Eric Anderson, Ph.D.; Michael McDermott,  Ph.D.; Kyle Barrett, Kyle T. Baron, Pharm.D., Ph.D.; Timothy Waterhouse, Ph.D.; Seth Green, M.S.; Katherine Kay, Ph.D. W-088 - Population Pharmacokinetic and Exposure-Response Modeling Analyses to Support Valemetostat Dose Recommendations in relapsed/refractory (R/R) Peripheral T-cell Lymphoma (PTCL) patients. Hiroyuki Inoue et al with co-author contributions from Ramon Garcia, Ph.D. W-046 - Quantitative Systems Pharmacology Modeling of X-linked Hypophosphatemia Disease Pathway Normalization to Predict the Impact of Burosumab Treatment on Serum Biomarkers in Adult and Pediatric Patients Daisuke Takaichi et al with co-author contributions from Kiersten Utsey, Ph.D.; Matthew Riggs, Ph.D., FISoP. W-120 - Reinforcement Learning for Pharmacometrics: A Proof of Concept and Future Directions. Annaliese Wieler, M.S.; Matthew Wiens, M.A.; Samuel P. Callisto, Ph.D.; Megan Cala Pane, Ph.D.; Hillary Husband, Ph.D. W012 - Scientific Project Management (SPM) to Enhance Model-Informed Drug Development. Jeannine Fisher, M.S.; William Knebel Pharm.D, Ph.D; Matthew Riggs, FISoP, Ph.D; Bryon Baxter; Uchenna Emechebe, Ph.D; Joseph Pliss, M.B.A.  W031 - Simulating Dynamic Adaptive Dosing Regimens from PK and PKPD Models Using mrgsolve Kyle Baron, Pharm.D., Ph.D. W-007 We look forward to seeing you! #ACoP2024 #Simulation #DrugDevelopment #Pharmacometrics #MetrumRG