Singleron Biotechnologies

We have a big reveal to make💡 👉 Reserve your spot at #FoG2025 to get the first look! https://lnkd.in/g7He4E4q #Singleron #SingleCellAutomation

#CustomerPublicationWeekly The Sweet Kill? Peripheral blood #immune cells playing a pivotal role in the ongoing surveillance of #cancer cells. Using #singlecell #multi-omics method that can simultaneously detect transcriptome, T cell receptor (TCR) repertoire, and LacNAc glycan profiling, the immune cells in the blood of bladder cancer patient were analyzed. This study revealed significantly higher levels of LacNAc on the peripheral T cells from early-stage bladder cancer patients. Furthermore, T cells with elevated surface LacNAc levels demonstrate enhanced cytotoxic activity and greater TCR clonal expansion. These results highlight LacNAc as a potential surface marker of effector T cells in bladder cancer. Singleron's GEXSCOPE Single Cell RNA+VDJ Library kit was used in this study. https://lnkd.in/eRFikigf

We're #hiring a new Marketing Specialist in Singapore. Apply today or share this post with your network.

We're going to #FOG2025 🙌 The UK's largest #Genomics event is taking place at ExCeL in #London on Wednesday 29th January & Thursday 30th January. 🔹 Curious how single cell sequencing can accelerate your research? Visit our booth #187 and get a chance to talk to our CEO and Founder Nan Fang, together with Julia Peisert, Product Manager, about Singleron’s unique portfolio. Stay tuned for updates from the festival – we have a big reveal to make!💡 👉 Reserve your spot at the live event and be the first to know! https://lnkd.in/g7He4E4q #SingleronBiotechnologies #SingleCell #MultiOmics #FestivalofGenomics

Congratulations to to Univ.-Prof. Dr med. Dr h.c. Sergiu Groppa, MBA and team for their recent publication in in Signal Transduction and Targeted Therapy! The study utilized single-cell RNA sequencing (scRNA-seq) on over 101,000 individual cells, uncovering significant transcriptomic changes in glial cell types within the Parkinson's Disease (PD) cortex. By integrating these molecular findings with electrophysiological data, the authors revealed "pan-glial" immunometabolism dysregulation as a central pathological mechanism. These pathways present promising targets for novel immunotherapeutic strategies in PD. Excited to see how this research paves the way for further breakthroughs! Singleron sCelLiVE tissue preservation and dissociation kit and GEXSCOPE Single Cell RNA Library Kit was used in study. #Parkinsons #microglia #singlecell

𝘀𝗰𝗥𝗡𝗔-𝘀𝗲𝗾 𝘃𝘀. 𝘀𝗻𝗥𝗡𝗔-𝘀𝗲𝗾: 𝗪𝗵𝗶𝗰𝗵 𝗦𝗵𝗼𝘂𝗹𝗱 𝗬𝗼𝘂 𝗖𝗵𝗼𝗼𝘀𝗲 𝗳𝗼𝗿 𝗬𝗼𝘂𝗿 𝗡𝗲𝘅𝘁 𝗣𝗿𝗼𝗷𝗲𝗰𝘁? We conducted a side-by-side comparison using mouse brain tissues and outlined key considerations to help you decide. Explore the results in our latest application notes —links in the comments! Planning your next single-cell project? Contact our team of experts at 𝗶𝗻𝗳𝗼@𝘀𝗶𝗻𝗴𝗹𝗲𝗿𝗼𝗻.𝗯𝗶𝗼. We're here to answer all your questions! #scRNAseq #snRNAseq

Another baby #Singleronie is joining the family 💖 as our Senior Marketing Manager Dr. Samantha Langer embarks on the beautiful journey of motherhood. We wish you joy, love, and rest during these months, creating beautiful moments with your growing family. Best of wishes from the Singleron team! 🎀 ✨

🚨 Discover the Ultimate Single Cell Automation! We’re unveiling a game-changer for high throughput single cell analysis at the Festival of Genomics & Biodata 2025. Join us to see how we make single cell sequencing faster, easier, and more consistent for you. 📅 29 Jan | 4:00 PM | Booth #187 👉 Sign up now to reserve your spot at the live event! https://lnkd.in/g7He4E4q #FoG2025 #singlecellpower #automation

#CustomerPublicationWeekly Persistent H. pylori infection triggers the repair program of the mucosa, such as spasmolytic polypeptide-expressing metaplasia (#SPEM). An increase in telomerase reverse transcriptase (TERT) protein expression is observed in chief cells upon infection with cagA-positive H. pylori and TERT knockout significantly ameliorated H. pylori-induced SPEM. #single-cell RNA sequencing revealed suppressed Wnt/β-Catenin pathway in gastric cells with TERT knockout. CagA appears to elevate TERT abundance by disrupting the interaction between TERT and its novel E3 ligase, SYVN1. This study sheds lights on mechanism underlying which CagA activated the TERT/Wnt/β-Catenin pathway and provides molecular basis for targeting CagA-activated Wnt signaling in chief cells for the treatment of gastric precancerous lesions. Singleron's GEXSCOPE Single Cell RNA Library Kit was used in the study. https://lnkd.in/e6wYawca

#CustomerPublicationWeekly Immune infiltration within the tumor microenvironment (#TME) is important for immune checkpoint blockade (#ICB) therapy to function. Mild photothermal therapy (PTT) is often combined with immunotherapy to enhance efficacy, likely by increasing immune cell infiltration and stimulating T-cell activity. Notably, the PTT also accelerates the release of tumor cell-derived exosomes (TEX) and upregulates PD-L1 expression on both tumor cells and TEX. A multi-stage drug delivery system is designed that concurrently delivers photosensitizers (reduced graphene oxide nanosheets, NRGO), anti-PD-L1 antibodies, and exosome inhibitors (sulfisoxazole). This local combination therapy remodels the immunosuppressive TME through exosome inhibition and enhanced immune cell infiltration, while also boosting T-cell activity to trigger systemic antitumor immunity- making it a promising approach to further improve immunotherapy efficacy. Singleron's GEXSCOPE Single Cell RNA Library Kit was used in this study to analyze TME. https://lnkd.in/e6-2VSQF