Society of Toxicology (SOT)

Get the most out of your trip to #2025SOT in Orlando, Florida! Stay at Hilton Orlando or other SOT block hotel for exclusive rates for meeting attendees. Book today through Connections Housing and enjoy the convenience! https://lnkd.in/gkkNJ_du

Noah Whiteman, PhD, a professor at UC Berkeley, shares his unique perspective on toxins, stemming from his background in entomology and plant-insect interactions. He explores how toxins impact the ecology and evolution of various organisms, from insects to humans, in Season 4 Episode 8 of Adverse Reactions. Listen now: https://lnkd.in/gY95aCk7

“There is a variety of electrophiles in the environment. In addition, there are precursor chemicals that undergo metabolic activation by enzymes and conversion to electrophiles in the body. Although electrophiles covalently bind to protein nucleophiles, they also form adducts associated with adaptive or toxic responses. Low molecular weight compounds containing sulfur are capable of blocking such adduct formation by capturing the electrophiles. In this review, we present our findings on the capture and inactivation of electrophiles by: (i) intracellular glutathione, (ii) reactive sulfur species, and (iii) extracellular cysteine (formed during the production of sulfur adducts). These actions not only substantially suppress electrophilic activity but also regulate protein adduct formation.”—From a Contemporary Review by Yoshito Kumagai et al. in the January 2025 issue of Toxicological Sciences. https://lnkd.in/gXUhs5JX #FreeToRead

Join the SOT Risk Assessment Specialty Section for "An Update on Vaping in Two Parts."

Attending #2025SOT in Orlando, Florida? Don’t miss out on special rates at Embassy Suites by Hilton and other SOT hotels, reserved just for registrants! Book now through Connections Housing and be steps away from the event. https://lnkd.in/g5TKaTWh

Us in Lotsch lab enjoyed the 2024 Southeastern Region of the Society of Toxicology (SOT) Fall Meeting here at Auburn University. 🧬🧫 My first SOT conference was intellectually stimulating and I cannot wait for the next! Congratulations to Dr. Ábner Magalhães Nunes on winning another 1st place Post-Doc oral presentation and Nicole Debia 2nd place award for graduate oral presentation.

Visit the ToxExpo Exhibit Hall during the #2025SOT Annual Meeting and ToxExpo for three days of exhibits featuring companies and organizations that support toxicologists and the toxicology community. Exhibitors include research organizations, government agencies, laboratory suppliers, drug developers, consulting firms, and academic institutions. You can stop by to visit with these exhibitors between sessions, during lunch, or at other times throughout the day to learn about products and services, job opportunities, new technology, and more. Learn more about ToxExpo: https://lnkd.in/g8b5ssEy

The January 2025 issue of Toxicological Sciences includes a Contemporary Review that presents findings on the capture and inactivation of electrophiles by intracellular glutathione, reactive sulfur species, and extracellular cysteine while an In-Depth Review outlines mechanistic investigations into tolvaptan and associated idiosyncratic drug-induced liver injury events. A Forum article covers potential next steps for sponsors to reduce animal use in drug development while a Research Brief highlights the limitation of using acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models. Additionally, two #ToxSpotlight articles are featured: One highlights the development of machine learning–based quantitative structure–activity relationship models for predicting plasma half-lives of drugs in six common food animal species while the other reports human serum albumin affinities for 65 structurally diverse PFAS from 20 chemical classes. Discover the latest impactful research in toxicology in the January 2025 issue of ToxSci: Your science. Your journal. https://lnkd.in/gcRjsBnK

Planning to attend #2025SOT in Orlando, Florida? Book your stay at the Castle Hotel or another SOT hotel for convenience and exclusive rates available to meeting registrants! Secure your spot today through Connections Housing and stay close to the action: https://lnkd.in/emEhz-dc

Sometimes negative results can be just as interesting as positive ones. Nivetha Subramaniam, a McGill University student, explores her research on potential cardiovascular risks from exposure to arsenic and cadmium mixtures in Season 4, Episode 7 of the Adverse Reactions podcast. Listen now: https://lnkd.in/gzescfrM