Tempo Bioscience

First described by German anatomist Karl Wilhelm von Kupffer in 1876, Kupffer cells are a subset of macrophages that reside in the liver. Morphologically, they vary in size and have an irregular stellate shape, with bean-shaped nuclei. Elongated processes that extend from the cytoplasm help them to anchor to the luminal surface of sinusoidal endothelial cells. Kupffer cells are the largest population of tissue-resident macrophages, constituting approx. 80-90 % of all macrophages found in the human body and 2-5 % of the total liver mass. As the liver’s primary immune sentinels, they form a crucial first line of defense against pathogens and foreign materials entering through the portal circulation (the system that carries blood from the abdominal organs to the liver). In contrast to other tissue-resident macrophages, e.g., alveolar or splenic macrophages, Kupffer cells are directly exposed to the circulation which allows them to efficiently monitor and filter the blood supply. Their strategic location within the liver architecture enables them to perform their critical functions in maintaining liver homeostasis and immune surveillance. #biotech #lifesciences #checkout 👇 https://hubs.li/Q02-T1tl0

Great event! via Biotech Networks #biotech #SanFrancisco 👏 👍 😊 https://lnkd.in/g94ym_V5

Trogocytosis, from trogo meaning ‘to gnaw’ or ‘to nibble’ in Ancient Greek, is an active process during which one cell receives cell surface molecules and membrane fragments from another cell in a unidirectional and cell-contact dependent manner. 🔔 Why is trogocytosis important?👇 https://hubs.li/Q02W5p1w0

Tempo-iOligo™ was cited in Nature in a major infectious disease study that offers the first explanation as to why herpes simplex virus 1 (HSV-1) infection in the brain is very rare. The study used #CRISPR screens to find new factors involved in controlling HSV-1 replication in the brain, and found that depletion of the transmembrane protein TMEFF1 in human neurons and in mice led to increased viral replication and neuronal death following HSV-1 infection. via Nature Portfolio Paludan Lab via Aarhus University https://hubs.li/Q02Q_M2M0

In our latest article, we delved into the activation of mast cells during IgE-mediated allergic responses. Now, we're shifting focus to how mast cells, along with microglia and the blood brain barrier, play a role in inflammation within the central nervous system. We'll provide a brief overview of microglia and the blood brain barrier before discussing their contributions to CNS inflammation and the implications of chronic neuroinflammation. Read on! 👇 https://hubs.li/Q02HL0Pk0

Did you know that mast cells are tissue-resident immune cells derived from the myeloid lineage? Along with basophils, eosinophils, and neutrophils, they belong to the granulocyte family of white blood cells. #Checkout our introductory article below👇Stay tuned for more articles on this topic! #LifeSciences #biotech #drugdevelopment https://hubs.li/Q02yJXvL0

Drug discovery leaders convene for the Executive Roundtables at the Drug Discovery Biology Strategy Meeting at the Hard Rock Hotel in San Diego today. The Executive Roundtables are a hive of activity, fostering powerful connections and propelling the future of drug discovery! Industry leaders mingle, forging connections that can accelerate careers and unlock new opportunities. But these roundtables go beyond networking. Focused discussions led by experts dive deep into the most pressing challenges and opportunities facing the field. Diverse perspectives collide, sparking insightful exchanges that push the boundaries of knowledge. This collaborative environment isn't just about sharing ideas, it's about developing actionable solutions with real-world impact. Participants collaborate with peers to arrive at strategies that can be implemented in their organizations, shaping the future of the industry and driving positive change. The Executive Roundtables are more than networking events – they're catalysts for innovation and progress. A big thank you to our esteemed facilitators! Adam Marko, Hammerspace Zev Wisotsky, Ph.D., Revvity Signals Adam Mullick, Ionis Pharmaceuticals, Inc. Anastasia Velentza, Plexium Angela Huang, Tempo Bioscience Amish Patel, Ph.D., Calidi Biotherapeutics Bishu Nayak, Neologics Bio Dimitra Chalkia, Athos Therapeutics Inc Frederick Chang, Kekulai Géza Ambrus-Aikelin, Genesis Therapeutics Joan Chen, Ph.D, Boundless Bio John Leonard, Aeona Pharmaceuticals Philip Cheung, Refactor BioSciences Salah Mahmoudi, Reneu Bio Sanjeev Thohan, Cogentis Therapeutics, Inc. Stephanie Truhlar, Eli Lilly and Company Yuhua Ji, Grace Science, LLC

Begin on a journey of innovation and collaboration at our Drug Discovery Biology and Bioinformatics Strategy Meeting, taking place tomorrow, May 14th, at the prestigious Hyatt Regency Princeton. Explore into the frontier of scientific breakthroughs with an assembly of brilliant minds charting the course towards innovative solutions. Our esteemed lineup of speakers brings together thought leaders and trailblazers, each bringing their unique expertise and perspective to the table: Christopher Conway - President, Research and Development, Curia Grant Carr - Vice President, Head of Global R&D Drug Discovery, Curia Andrew Zhang - Director, Head of Chemical Biology, AstraZeneca Aaron Mackey - Former SVP, AI & Data Science Abhijat Vatsyayan - Head of Artificial Intelligence, Taiho Oncology, Inc. Angela Huang - Founder & President, Tempo Bioscience Claudette L. F. - Vice President, Global Head of Non-Clinical Safety & Toxicology, Genmab douglas kitchen - Research Fellow, Medicinal Chemistry, Curia Gregory Williams - Senior Research Scientist II, Cellular Assay Technologies, Curia Ernane Souza, PhD, RPh - Assistant Director, Translational PKPD and DMPK, Supernus Pharmaceuticals, Inc. Frank Leu - Founder & Managing Member/Managing Member, Biopharmatrix LLC / NOVAPEUTICS, LLC Gunaretnam (Guna) Rajagopal - Venture Partner - Samsara BioCapital Marcie Glicksman - VP Biology, EnClear Therapies Mark Tornetta - Vice President of Biologics Discovery (TavoSelect), Tavotek Biotherapeutics ML Ujwal - Associate Director, Data Science, R&D J&J US Nikolaos Tezapsidis - President & CEO, Neurotez, Inc. Paul Kayne - Vice President, Biological Sciences, Palatin Technologies Each speaker brings a unique perspective and years of invaluable experience to the table, promising thought-provoking discussions and actionable insights that transcend conventional boundaries. From Target identification to the intricacies of biological pathways, our speakers will shed light on the cutting-edge strategies shaping the future of drug discovery. This strategy meeting isn't just about listening—it's about collaboration, networking, and forging meaningful connections with fellow innovators. Engage in lively discussions, exchange ideas, and connect with like-minded professionals who share your vision for a healthier, more prosperous future. See you at the Drug Discovery Biology and Bioinformatics Strategy Meeting in Princeton! #DrugDiscovery #Bioinformatics #Innovation #Healthcare #PrincetonEvent #Science #Biology #Biotechnology

Did you know that biosensors are good at tracking LIVE-cell activities?🔬 Join us in embracing the power of biosensors for research and drug discovery! https://hubs.li/Q02q9Q6m0 #LifeSciences #3Dcellculture #neuroscience #cellbiology #diseases #biology #basicresearch #biotech

👍 Exciting news in the world of NASH therapeutic development! 🔔 Check out this updated article that highlights the recent FDA approval of Rezdiffra in March 2024. #lifesciences #biotech #FDAapprovals #drugdevelopment #drugdiscovery #pharma https://hubs.li/Q02qb7Jb0