23andMe’s Post

I am looking for evidence of lifetime physiological correlates with maximum lifespan. But how solid is this work? Seems there is a conflict of interest, as discussed in the comments section. Anyone know better sources?

The first map of the entire brain of a fruit fly has been published, promising to provide unprecedented knowledge into how the brain works and what goes wrong in different diseases. The FlyWire Consortium, an international team led by Princeton University, USA, and including EARA members, the Freie Universität Berlin, and Johannes Gutenberg University Mainz, Germany, successfully documented more than 50 million connections between almost 140,000 neurons in the brain of the adult fruit fly – this makes it the largest such map (connectome) that has been created. Mala Murthy, at Princeton, said: “It will help researchers trying to better understand how a healthy brain works. In the future we hope that it will be possible to compare what happens when things go wrong in our brains.” Read more: https://lnkd.in/eUGG5a93 #Drosophila #FruitFly #Brain #AnimalResearch #Neuroscience

Discover the interesting world of rats, from their complex affective and cognitive capacities to their evolutionary history, in this new issue of Science: https://lnkd.in/gQgp7rNA! They are not just cute; these unsung heroes of science offer new insights into disease transmission and more.

Happy to share this CUriosity feature by Lisa Marshall. In 2007 we published a paper showing that a soil-derived bacterium derived from mud near Lake Kyoga in Uganda, Mycobacterium vaccae, not only could suppress allergic airway inflammation [https://lnkd.in/gtMQzu2X], but, when given to the body or into the airways of mice (mimicking what happens when we breathe in dust), activates a small group of serotonin neurons in the brainstem that we believe is responsible for antidepressant effects [https://lnkd.in/gkVF4Ggs]. Indeed, further studies demonstrated increased serotonin activity in the prefrontal cortex and antidepressant-like behavior. We've learned a lot since then, but it continues to make us wonder if we should all be spending more time playing in the dirt. https://lnkd.in/guDuGm2g

How The #Microbiome Changes Our #Idea Of What It Means To Be #Human ! (1) A #New #Understanding of the #Microbiome suggest #Humans should think of themselves as #Metaorganisms. (2) Until recently, #Scientists believed that there were #Three #DiscreteParts of our #Nature that reflected solid aspects of an #IndividualSelf: #TheImmuneSystem, #TheGenome and #TheBrain. “None of these #Pillars of the traditional #Definitions of the #Self – #Immunity, #GenomeIntegrity, the #CentralNervousSystem – are free of #MicrobialImpact,” says Thomas-BOSCH at #KielUniversity in #Germany. (3) The #Microbes that colonise us, collectively known as the #Microbiome, challenge the concept of a #DiscreteSelf. These include #Bacteria, #Viruses and #Fungi, although the #Bacteria are the #BestStudied. Together, these #Microbes orchestrate the #ImmuneSystem, influence how the #Brain #Works and #Grows, and affect our #Personality and #Feelings. https://lnkd.in/gqGFfmYC

In a recent JBC study, researchers at Georgia State University College of Arts & Sciences showed that tau, the driver of Alzheimer’s disease, can destabilize dendrite activity-regulated cytoskeleton-associated protein, or Arc, which plays a key role in synaptic plasticity, learning and memory, via the proteosome degradation. This indicates that tau may drive memory loss by affecting synaptic plasticity via Arc. Image shows primary hippocampal neurons overexpressing GFP (top) or GFP-tau (bottom). Red and green show neuron morphology and purple shows the Arc protein. https://lnkd.in/enQ5kTak #Alzheimersdisease

Mosaic variants as natural barcodes enabled a new direction to study relationships between cells and cell populations glad to be part of this https://lnkd.in/gBsTKRP8

In a recent JBC study, researchers at Georgia State University College of Arts & Sciences showed that tau, the driver of Alzheimer’s disease, can destabilize dendrite activity-regulated cytoskeleton-associated protein, or Arc, which plays a key role in synaptic plasticity, learning and memory, via the proteosome degradation. This indicates that tau may drive memory loss by affecting synaptic plasticity via Arc. Image shows primary hippocampal neurons overexpressing GFP (top) or GFP-tau (bottom). Red and green show neuron morphology and purple shows the Arc protein. https://lnkd.in/enQ5kTak #Alzheimersdisease

Can random changes over time effectively predict aging? New research shows that stochastic variation alone could create aging clocks that correlate with actual biological age. #diagnostics #innovation #aging #agingclocks #biologicalage

Dr. Ronald Klatz, MD, DO Worldhealth.net Scientists have discovered that stopping the buildup of the protein F-actin in #aging fruit flies' #brains preserves cell function and reduces #cognitive decline. Normally, F-actin disturbs cell's natural recycling process, leading to waste accumulation that damages neurons. By adjusting specific genes in the flies' neurons, researchers prevented this buildup, supported cellular cleanup, and extended the flies' healthy #lifespan by about 30%. #worldhealth #antiaging #aging #antiagingmedicine #regenerativemedicine #medicine #clinicalresearch https://lnkd.in/gx6aaZQ2