Ace Therapeutics’ Post

🚀 Exciting research! We’re thrilled to highlight a groundbreaking paper that presents a method for developing a model for Alcohol-associated liver disease (ALD) using liver organoids derived from adipose stromal/stem cells (hASCs). 🌟 ALD encompasses a range of conditions caused by excessive alcohol consumption, leading to liver damage. It's a major cause of liver-related morbidity and mortality worldwide. The lack of human-relevant models has been a significant barrier in ALD research and drug development—until now. Organoids are revolutionizing disease modeling by providing more accurate and controlled environments for studying diseases. This paper focuses on the generation of hASCs-derived hepatocellular organoids (hAHOs) and liver organoids (hALOs). The study found that hALOs are more suitable for creating an in-vitro model of ALD than hAHOs. Key findings include: -Ethanol-treated hALOs replicate initial symptoms of alcohol-associated steatosis and inflammation. -These organoids exhibit dysfunctional mitochondria and endoplasmic reticulum stress. -Upregulated expression of alcohol-metabolizing enzymes seen in ALD. This model holds promise for providing insights into ALD research and potentially leading to the development of ALD-specific drugs. 🔍 Dive into the details and explore the possibilities. Learn more - https://lnkd.in/gWFY4xDn #LiverDisease #ALDResearch #Organoids #StemCells #ScientificBreakthrough #ThermoFisher

🚀 Exciting research! We’re thrilled to highlight a groundbreaking paper that presents a method for developing a model for Alcohol-associated liver disease (ALD) using liver organoids derived from adipose stromal/stem cells (hASCs). 🌟 ALD encompasses a range of conditions caused by excessive alcohol consumption, leading to liver damage. It's a major cause of liver-related morbidity and mortality worldwide. The lack of human-relevant models has been a significant barrier in ALD research and drug development—until now. Organoids are revolutionizing disease modeling by providing more accurate and controlled environments for studying diseases. This paper focuses on the generation of hASCs-derived hepatocellular organoids (hAHOs) and liver organoids (hALOs). The study found that hALOs are more suitable for creating an in-vitro model of ALD than hAHOs. Key findings include: -Ethanol-treated hALOs replicate initial symptoms of alcohol-associated steatosis and inflammation. -These organoids exhibit dysfunctional mitochondria and endoplasmic reticulum stress. -Upregulated expression of alcohol-metabolizing enzymes seen in ALD. This model holds promise for providing insights into ALD research and potentially leading to the development of ALD-specific drugs. 🔍 Dive into the details and explore the possibilities. Learn more - https://lnkd.in/gWFY4xDn #LiverDisease #ALDResearch #Organoids #StemCells #ScientificBreakthrough #ThermoFisher

🚀 Exciting research! We’re thrilled to highlight a groundbreaking paper that presents a method for developing a model for Alcohol-associated liver disease (ALD) using liver organoids derived from adipose stromal/stem cells (hASCs). 🌟 ALD encompasses a range of conditions caused by excessive alcohol consumption, leading to liver damage. It's a major cause of liver-related morbidity and mortality worldwide. The lack of human-relevant models has been a significant barrier in ALD research and drug development—until now. Organoids are revolutionizing disease modeling by providing more accurate and controlled environments for studying diseases. This paper focuses on the generation of hASCs-derived hepatocellular organoids (hAHOs) and liver organoids (hALOs). The study found that hALOs are more suitable for creating an in-vitro model of ALD than hAHOs. Key findings include: -Ethanol-treated hALOs replicate initial symptoms of alcohol-associated steatosis and inflammation. -These organoids exhibit dysfunctional mitochondria and endoplasmic reticulum stress. -Upregulated expression of alcohol-metabolizing enzymes seen in ALD. This model holds promise for providing insights into ALD research and potentially leading to the development of ALD-specific drugs. 🔍 Dive into the details and explore the possibilities. Learn more - https://lnkd.in/gWFY4xDn #LiverDisease #ALDResearch #Organoids #StemCells #ScientificBreakthrough #ThermoFisher

🚀 Exciting research! We’re thrilled to highlight a groundbreaking paper that presents a method for developing a model for Alcohol-associated liver disease (ALD) using liver organoids derived from adipose stromal/stem cells (hASCs). 🌟 ALD encompasses a range of conditions caused by excessive alcohol consumption, leading to liver damage. It's a major cause of liver-related morbidity and mortality worldwide. The lack of human-relevant models has been a significant barrier in ALD research and drug development—until now. Organoids are revolutionizing disease modeling by providing more accurate and controlled environments for studying diseases. This paper focuses on the generation of hASCs-derived hepatocellular organoids (hAHOs) and liver organoids (hALOs). The study found that hALOs are more suitable for creating an in-vitro model of ALD than hAHOs. Key findings include: -Ethanol-treated hALOs replicate initial symptoms of alcohol-associated steatosis and inflammation. -These organoids exhibit dysfunctional mitochondria and endoplasmic reticulum stress. -Upregulated expression of alcohol-metabolizing enzymes seen in ALD. This model holds promise for providing insights into ALD research and potentially leading to the development of ALD-specific drugs. 🔍 Dive into the details and explore the possibilities. Learn more - https://lnkd.in/gWFY4xDn #LiverDisease #ALDResearch #Organoids #StemCells #ScientificBreakthrough #ThermoFisher

🔥 【Signaling Pathway - Ak/tPKB】 💡 Akt can regulate cell survival signals activated by cytokines, growth factors and Oncogene Ras, which is very common in eukaryotic regulatory networks.  🎯 Akt signal pathway is closely related to the occurrence and development of various diseases such as malignant tumors, diabetes, and rheumatoid arthritis, and therefore it has attracted more and more attention. 👉 More info: https://lnkd.in/dxX7Kvi #CellSignals #Akt #Cytokines #Tumors #Biotechnology 

Congratulation to Dr. Priyankar Dey’s team on their recent research investigating the cellular mechanisms underlying the hepatoprotective effects of Nerium oleander. Their study revealed how oleander mitigates endotoxin-induced damage to hepatocytes. By using an in vivo model to test anti-inflammatory and metabolic health benefits, followed by evaluating oleander's impact on LPS-treated HepG2 cells, they provided strong evidence of oleander's hepatoprotective effects. In this study, HepG2 cell counting was performed using our automated cell counter, FACSCOPE® B. We are grateful for FACSCOPE® B being part of the research. To read the full article: https://lnkd.in/gMf3JAu9 More information about FACSCOPE® B: https://lnkd.in/gQ6SBw-H #cellcounting #FACSCOPE #Curiosis #HepG2 #LPM #oxidative #Nrf2 

Gout is a common type of inflammatory arthritis linked to abnormal uric acid metabolism, resulting in the accumulation of urate crystal deposits in joints. To support the development of effective gout therapies, precise animal models are needed to properly evaluate drug candidates. At this year’s meeting of the American Association of Immunologists, WuXi AppTec presented a poster highlighting the development of multiple preclinical acute gout models, including an air pouch model, an intra-articular injection model, and a hyperuricemia gout model. Click 👇 to learn more. Questions? Contact us here: https://lnkd.in/eG97YXCs #AAI #Immunology2024 #Immunology #Gout #Hyperuricemia #AirPouch #UricAcid #Arthritis #Inflammation https://lnkd.in/eYVFaWCS

📢 New Publication Alert 💡 Title: #Dysregulation of BCL-2 family proteins in blood neoplasm: therapeutic relevance of antineoplastic agent venetoclax 🧐 Authors: Faris Tayeb 🔏 Keywords: BCL-2 family proteins #apoptosis cellular stress BH3-only proteins blood neoplasm therapeutic strategies #hemostasis Curious to know more? Dive into the article: https://lnkd.in/enqNnV9K

📢 New Publication Alert 💡 Title: #Dysregulation of BCL-2 family proteins in blood neoplasm: therapeutic relevance of antineoplastic agent venetoclax 🧐 Authors: Faris Tayeb 🔏 Keywords: BCL-2 family proteins #apoptosis cellular stress BH3-only proteins blood neoplasm therapeutic strategies #hemostasis Curious to know more? Dive into the article: https://lnkd.in/emy7Tkjj

Yesterday, DefiniGEN’s Founder and CSO Prof. Ludovic Vallier gave an illuminating and insightful seminar: "Understanding Human Organogenesis to Develop Therapies Against Liver Diseases." The talk covered his research into molecular mechanisms governing liver development, focusing on the generation of #cholangiocytes and #hepatocytes. Specifically, he shared how his team is investigating the mechanisms driving progression of non-alcoholic fatty liver disease and how these insights could help develop new regenerative therapies. If you missed this talk, fear not! You can visit our website to learn more about how DefiniGEN’s OPTI-Hep platform can accelerate your research into liver disease modelling and drug screening: https://lnkd.in/eRVXmF4U   #BiomedicalResearch #LiverDisease #StemCellResearch #Liver #BabrahamInstitute