Amélie Raby’s Post

Gut health matters! The intestinal immune system and gut barrier are an important line of host defense. The new Transgelin ELISA it is a powerful tool next to our I-FABP ELISA, aiding in assessment and localization of gut damage. Very helpful for studying ischemia/reperfusion damage, inflammatory diseases like IBD or IBS, and leiomyosarcoma.

Gut health matters! Our new Transgelin ELISA kit offers a non-invasive method to assess the severity of gut damage caused by acute intestinal ischemia, specifically by detecting disruptions in smooth muscle cells. When used together with I-FABP, a biomarker for epithelial gut damage, it provides an alternative approach to localize and evaluate intestinal injury without the need for invasive procedures like colonoscopy. #Research #ELISA #Transgelin #SM22 #Gastroenterology #IFABP #LBP https://lnkd.in/euQJ8UpK

#citation 🦴 New research from Xiangya Hospital of Central South University reveals the role of bone marrow adipocytes (BMAds) in bone homeostasis and skeletal aging. ☑ Exercise was shown to inhibit PCLAF secretion from bone marrow macrophages, reducing BMAds senescence and skeletal aging. Genetic deletion of PCLAF delayed skeletal aging, while PCLAF-induced senescent BMAds suppressed bone turnover. ☑ PCLAF binds to ADGRL2, inhibiting AKT/mTOR signaling and spreading senescence. A newly developed PCLAF-neutralizing antibody showed therapeutic effects on skeletal health in aged mice. This study identifies PCLAF as a key inducer of BMAds senescence and offers a potential treatment for age-related osteoporosis. 💡 Read more here: https://lnkd.in/giqY_FyF Cyagen is proud to contribute to this research with our Lyz2-Cre mice. 🐭 Learn more about our services here: https://lnkd.in/gDFGmMty #BoneHealth #OsteoporosisResearch #ScientificBreakthrough #HealthcareInnovation #cyagen #biotech #knockin #mousemodels #mousemodel #biotechnology #biosciences #scienceofreading #researchmatters #research

In their study in animal model, the researchers figured out that when cells are signaled to have nutrients in excess, it leads to malfunction and inflammation in organs such as the pancreas, the liver, and the kidneys. Immune cells accumulate and, instead of repairing, trigger inflammation that further increases problems in those organs. The findings not only link mildly increased nutrient signaling to limited lifespan in mammals, but the authors add that they also “support a two-component process of parenchymal damage and myeloid inflammation that together precipitate a time-dependent organ deterioration that limits longevity". For detailed information, please read here: https://lnkd.in/gaue4Ju5

Part 2: Method: We used exposure to a bacterial lipopolysaccharide (LPS) to induce neonatal endotoxemia in the mice. Results: It was found that NGN (100 mg/kg i.p.) exposure during the neonatal period reduced leukocyte migration and decreased pro-inflammatory cytokine (TNF-α, IL-1β and IL-6) levels in the lungs, heart, kidneys or cerebral cortex. In addition, NGN upregulated IL-10 production in the lungs and kidneys of neonate mice. The administration of NGN also enhanced antioxidant enzyme catalase and SOD activity, reduced lipid peroxidation and protein carbonylation and increased the reduced sulfhydryl groups in an organ-dependent manner, attenuating the oxidative damage caused by LPS exposure. NGN decreased ERK1/2, p38MAPK and COX-2 activation in the lungs of neonate mice. Moreover, NGN complexed with HPβCD was able to increase the animal survival rate. Conclusion: NGN attenuated inflammatory and oxidative damage in the lungs, heart and kidneys caused by neonatal endotoxemia through the MAPK signaling pathways regulation. Our results show that NGN has beneficial effects against neonatal endotoxemia and could be useful in the treatment of neonatal inflammatory injuries. Heimfarth L, Int J Biol Macromol. 2024 Feb 28:130500. doi: 10.1016/j.ijbiomac.2024.130500. Epub ahead of print. PMID: 38428770. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

🧠 【April Issue of ENT Released】 📢 Welcome to read, download, or cite these interesting articles. This issue includes six wonderful articles with various focus topics. 🔗 Check them all at https://lnkd.in/g6GgwUP9 #neurogenesis #multiple sclerosis #neuronal plasticity #Biomarkers #neurodegenerative diseases #Alzheimer’s disease #Short-chain fatty acids #paper #review #Exploration of Neuroprotective Therapy

❗ Missing IER3IP1 #protein leads to severe #brain developmental disease Study by the "Membrane Transport" research group at the Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI) in #Jena sheds light on the molecular mechanisms of a rare disease. A study entitled "IER3IP1-mutations cause microcephaly by selective inhibition of ER-Golgi transport", now published in the open access journal "Cellular and Molecular Life Sciences", provides new insights into the #molecular causes of a rare and usually fatal hereditary disease called MEDS1. The #disease is characterized by #microcephaly (a head that is too small with a simplified brain pattern), epilepsy and diabetes. Affected children usually die at an early age. The underlying cause is #mutations in the IER3IP1 #gene, which codes for a small protein in the membrane of the endoplasmic reticulum (ER). This protein plays a crucial role in the transport of molecules between the ER and the Golgi apparatus. Publication: IER3IP1‑mutations cause microcephaly by selective inhibition of ER‑Golgi transport. Mihaela Anitei, Francesca Bruno, Christina Valkova, Therese Dau, Emilio Cirri, Iván Mestres, Federico Calegari, Christoph Kaether. Cellular and Molecular Life Science, 2024? 👉 Publication: DOI: https://lnkd.in/e_F4qUgr   👉 More information: https://bit.ly/3Tq2lpt (German: https://bit.ly/47r27V2) #microcephaly #Hereditarydisease #braindevelopmentaldisease #Membranetransport #molecularmechanisms

#kidney #nephrology #research https://lnkd.in/gQtKKE2A Abstract #Sirtuins (SIRTs) are putative regulators of #lifespan in model organisms. Since the initial discovery that SIRTs could promote longevity in nematodes and flies, the identification of additional properties of these proteins has led to understanding of their roles as exquisite sensors that link #metabolic activity to oxidative states. SIRTs have major roles in biological processes that are important in kidney development and physiological functions, including #mitochondrial metabolism, oxidative stress, #autophagy, DNA repair and #inflammation. Furthermore, altered SIRT activity has been implicated in the pathophysiology and progression of acute and chronic kidney diseases, including acute kidney injury, diabetic kidney disease, chronic kidney disease, polycystic kidney disease, autoimmune diseases and renal ageing. The renoprotective roles of SIRTs in these diseases make them attractive therapeutic targets. A number of SIRT-activating compounds have shown beneficial effects in kidney disease models; however, further research is needed to identify novel SIRT-targeting strategies with the potential to treat and/or prevent the progression of kidney diseases and increase the average human healthspan.

**Organ Regeneration: Your Liver Regrows Even if 75% is Removed** Did you know that your liver can regrow even if 75% of it is removed? This unique organ can grow back to its original size through a process called compensatory hyperplasia. When part of the liver is removed, the remaining portion begins to rapidly produce new cells to restore its full function. Unlike most organs, the liver doesn't regrow exactly the same shape, but it regenerates enough tissue to perform its essential tasks, such as filtering toxins from the blood, producing bile, and regulating metabolism. This regenerative ability is one of the reasons liver transplants and partial liver donations are possible. Even with significant portions removed, both the donor and recipient can eventually have fully functional livers. #Health #MedicalScience #OrganRegeneration #LiverHealth #Transplantation #MedicalLaboratoryTechnology #Microbiology #Phlebotomy #LaboratoryTesting #DiagnosticTesting #HealthcareProfessional #MedicalTesting #ClinicalLaboratory #BiomedicalScience #HealthcareIndustry #MedicalScience #LaboratoryMedicine #ClinicalMicrobiology #InfectionControl #PhlebotomyTechnician #MedicalLabTechnician #MicrobiologyLab #ClinicalLab #HealthcareCareer #MedicalCareer #ScienceCareer #COVID19Testing #Virology #Bacteriology #Parasitology #MolecularDiagnosis #GeneticTesting #Cytology #Histopathology #Immunology #Serology Source: (1) Liver regeneration - Wikipedia. https://lnkd.in/di4_ZEzC. (2) Development of a hepatic cryoinjury model to study liver regeneration. https://lnkd.in/d_arM-vK. (3) Hyperplasia - Definition, Causes, Types and Quiz - Biology Dictionary. https://lnkd.in/du34AKgm. (4) Hyperplasia - Wikipedia. https://lnkd.in/dtxamd3z. (5) undefined. https://lnkd.in/djqXRxqV.