American Society for Biochemistry and Molecular Biology (ASBMB)’s Post

Our latest paper showcases how liquid chromatography tandem mass spectrometry (LC-MS/MS) can revolutionize pheromone analysis in honey bee research!. Since the initial description of queen mandibular pheromone (QMP) in 1988, studies have relied heavily on GC-MS. Our research demonstrates that QRP components are compatible with LC-MS/MS, allowing for the simultaneous detection of pheromones and a wide range of other biologically relevant compounds, such as prostaglandins and thromboxanes. The spectral data are openly accessible at the #metabolomicsworkbench (ST003101, doi: 10.21228/M81B11), allowing for further analysis or improvements in annotation as new pathways are discovered and new standards and annotation technologies become available. This comprehensive dataset will serve as a valuable resource for ongoing exploration. https://lnkd.in/grChtWeD

🎉 A successful conclusion of the Special Issue "Bioengineering and Synthetic Biology Approaches for High-Value Compounds"! 🥼 This Special Issue is guest-edited by Dr. Wei Liu, Dr. Xinjun Feng and Dr. Min Liu. 👏 5 papers have been published in this Special Issue. 🔗 Click the link for more details about the Special Issue and access the publications freely: https://lnkd.in/d5iW_tV4. #chassis_cells #high_value_compounds #biosynthetic_pathways #enzymes #metabolic_engineering

Scientists at the Environmental Molecular Sciences Laboratory (EMSL) developed the RhizoMAP platform to enable researchers to trace and visualize complex metabolomic processes in the rhizosphere in the presence of the microbial community and in changing environments like drought conditions. Read about RhizoMAP in a newly published research highlight published on the EMSL website.: https://bit.ly/4g3gDoJ Research team contacts: Amir H. Ahkami, EMSL, Pacific Northwest National Laboratory Dusan Velickovic, EMSL, Pacific Northwest National Laboratory Kevin J. Zemaitis, EMSL, Pacific Northwest National Laboratory

What is #life? A very big question – and part of the answer might be in very small living systems: #bacteria. Initially discounted as simple “bags of molecules”, so-called biomolecular #condensates – dynamic, membraneless assemblies of proteins, nucleic acids and other biomolecules – have recently been recognized to play important roles in regulating bacterial processes. Since such condensates are abundant in all forms of life, they’re hypothesized to have been incubators for emerging life. Wade Schnorr and Seth Childers (University of Pittsburgh) discuss selected examples from both bacterial cell biology and systems chemistry research, showcasing how chemical reactions are closely linked to condensate phase separation and vice versa. They reinforce the case that biomolecular condensates could have been critical in the transition from matter to life, opening up exciting avenues for further research. Our Pick of the Week, published #OpenAccess in #ChemSystemsChem: "Biomolecular Condensates: From Bacterial Compartments to Incubator Spaces of Emergent Chemical Systems in Matter-to-Life Transitions" https://ow.ly/nmCp50S9Vjn Part of the "Systems Chemistry Talents" collection: https://ow.ly/HSxn50S9Vt3

FASEB BioAdvances is accepting submissions for a special collection focused on null findings in biological research. 🧪 Negative or non-significant results are just as important as positive ones. They drive transparency, collaboration, and progress in science. If your research supports the null hypothesis, contribute to advancing the scientific method by sharing your findings with the global community. 📅 Submission deadline: April 30, 2025 Learn more and submit: https://hubs.ly/Q02Qhhtd0 #NullResults #ScientificTransparency #BiologicalResearch #FASEBBioAdvances #OpenAccessScience #NegativeResults #PublishYourResearch

"Biochemistry is the language of life itself, not merely a branch of science. Discovering the mysteries of enzymes, DNA, and molecular structures serves as a potent reminder of how intertwined everything is. I can't wait to push the limits of science and delve further into the world of molecules! #ScienceInnovation #LifeAtTheMolecularLevel #Biochemistry #FutureOfScience

Exciting news in the world of biomolecular analysis! Refeyn is expanding its mass photometry product line, paving the way for more precise and efficient research. This advancement will empower scientists to unlock new insights in their studies. Let's embrace the future of analysis! Read more: https://lnkd.in/dSS7vHSM #BiomolecularBreakthrough #MassPhotometry #RefeynInnovation #FutureOfAnalysis #ScientificAdvancement #PrecisionResearch #UnlockingInsights #EfficiencyInScience #NextGenAnalysis #EmpoweringResearch

Rita Teixeira (researcher from Plant Stress & Signalling Lab at Faculdade de Ciências da Universidade de Lisboa) is the first-author and Rui Malhó (leader of the same lab) coordinates a new paper published on the The New Phytologist Foundation journal. Read this #bioisidigest to know all the details of this work, that sheds light on the mechanisms through which roots grow in the soil and pollen can achieve fertilization leading to seed production, two key aspects of plant growth and thus food production: https://bioisi.pt/news/101 This study is a multidisciplinary investigation that combines molecular and cell biology techniques, metabolomics and mechanical properties' assessment by atomic force microscopy, counting with the participation of BioISI researchers from FT-ICR and Structural Mass Spectrometry Lab and the Atomic Force Microscopy and Related Techniques Lab. Read the full paper: https://lnkd.in/d4jSXuyh #plantgrowth #pollentubes #multidisciplinary

Multi-angle light scattering (MALS), a technique that calculates molecular weight and size through the measurement of light scattered across many angles, is a powerful tool that has become ubiquitous in recent years. In this webinar, Steve Rosa and Lorena Lopez Peña of Agilent Technologies will investigate the main uses of MALS, including molecular weight determination, aggregation screening, molecular size, and shape. They will also showcase the new 1260 MALS detector from Agilent and examine some use cases seen with academic and industrial collaborators to demonstrate the wide variety of MALS applications and configurations, highlighting the benefits such a detector can add to macromolecular research. Register here: https://lnkd.in/efpXvhkN #LightScattering #Biochemistry #AnalyticalChemistry

𝟯️⃣ [ 𝗧𝗛𝗘 𝗩𝗛𝗛 𝗧𝗢𝗢𝗟𝗕𝗢𝗫 ] 𝗨𝗻𝗹𝗼𝗰𝗸𝗶𝗻𝗴 𝗻𝗲𝘄 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗶𝗻 𝗧𝗮𝘂 𝗳𝗼𝗹𝗱𝗶𝗻𝗴 𝗮𝗻𝗱 𝘀𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝘄𝗶𝘁𝗵 𝗼𝘂𝗿 𝗡𝗮𝗻𝗼𝗯𝗼𝗱𝗶𝗲𝘀®🔬    Our 𝗩𝗛𝗛 𝗧𝗼𝗼𝗹𝗯𝗼𝘅 continues to push boundaries in the field of Tau research! This spring, our synthetic nanobodies were highlighted in the Journal of Biological Chemistry (April 2024). The study from Isabelle Landrieu’s lab and collaborators explores how these nanobodies provide crucial insights into Tau folding, structural dynamics, and activity relationships. ➡️ 𝗪𝗵𝗮𝘁’𝘀 𝗡𝗲𝘅𝘁? We’re excited to share that more VHHs are in development! Clément DANIS and Elian Dupre, with the support of our PhD network European Network TauImmune, are working on new anti-Tau nanobodies that will further expand the capabilities of our toolbox.  𝗘𝘅𝗽𝗹𝗼𝗿𝗲 𝗼𝘂𝗿 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝗻𝗱 𝘀𝗲𝗲 𝗵𝗼𝘄 𝗼𝘂𝗿 𝗰𝘂𝘁𝘁𝗶𝗻𝗴-𝗲𝗱𝗴𝗲 𝗻𝗮𝗻𝗼𝗯𝗼𝗱𝗶𝗲𝘀 𝗰𝗮𝗻 𝗯𝗼𝗼𝘀𝘁 𝘆𝗼𝘂𝗿 𝗽𝗿𝗼𝗷𝗲𝗰𝘁 ! 🔗 https://lnkd.in/eKYNXnDv #Innovation #Biotechnology #Nanobodies #Tau #ScientificResearch #HybrigenicsServices #SyntheticNanobodies #TauResearch