Arc Institute’s Post

Researchers at The Ohio State University have created the ssREAD database, offering crucial insights into Alzheimer's disease. - Integrates diverse datasets for a comprehensive view - Focuses on molecular signatures through single-cell and single-nucleus RNA sequencing - Provides new perspectives on disease mechanisms and sex differences - User-friendly platform for advancing Alzheimer's research How might this resource change current approaches to studying Alzheimer's disease? #neuroscience #alzheimersresearch #pathologystudy #researchdatabase

Did a top NIH official manipulate Alzheimer's and Parkinson's studies for decades? It seems it happened again. More than 130 papers in top journals with apparent figure manipulation by a top NIH official. I usually post research articles, but I decided to write about my personal view today. As researchers we are part of a community, building knowledge based on previous knowledge. If someone cheats, it becomes impossible to learn how nature works. There is a reproducibility crisis. These lies when published in top journals became dogmas. How many grants are given to honest researchers who built hypotheses based on fabricated published data? Millions or billions of dollars are spent on developing therapeutics based on fake knowledge. How many clinical trials fail? How many useless drugs are being approved based on false data? Is it an ego problem? Misconduct by top researchers, who should be our role models... upsetting, irritating, sad... https://lnkd.in/ejfD_kYw #genetics #genomics #precisionmedicine #genomicmedicine #brain #neurology #neuroscience #neurodegeneration #alzheimer #parkinson #drugdiscovery #drugdevelopment #ethics #bioethics #clinicaltrials #fda #clinicalresearch #biomarkers #therapeutics #biotechnology #innovation #research #science #sciencecommunication

3 PhD programmes to get excited about A PhD programme provides an opportunity to contribute towards cutting-edge research in an area of academic study aligned with your passions and interests. Taipei Medical University (TMU) offers a trio of dynamic PhD programmes that promise to invigorate the realms of translational science, cancer biology and drug discovery, and medical neuroscience. These programmes not only delve into cutting-edge research but also prioritise hands-on experience, collaboration, and global engagement. https://lnkd.in/gaJxabGj #PhDprogramme #research #academicstudy #TMU #TaipeiMedicalUniversity #translationalscience #cancerbiology #drugdiscovery #medicalneuroscience #collaboration #globalengagement #innovation #biomedicalresearch #neuroscience #graduateschool #biomedicine #benchtobedside #cuttingedgeresearch #industrypartnership #educationalprogrammes #leadership #breakthroughs #internationalcollaboration #neurologicaldisorders #clinicalresearch

"My “OMG” moment occurred during my postdoctoral research. At the time, I became interested in the gut-brain axis. The microbiome was budding in the scientific research community during this time. While extensively studied in the context of GI illness, it was just making its way into the sphere of neurodegenerative and neuropsychological diseases. As a postdoc and an early career faculty member, a lot of my research was focused on studying microbial-based biomarkers and how they contribute to the pro-inflammatory milieu observed in neuropsychiatric diseases. While studying these microbes, I thought it important to understand the metabolomics, metabolites, and lipids that are created by these bugs." Tanya Nguyen, PhD Sapient Kate Stumpo Bruker Daltonics #massspectrometry #omics #neurosciences

Exciting news from the University of Wisconsin-Madison! A team of scientists has made a groundbreaking discovery in the field of neuroscience. They have developed a 3D-printed brain tissue that can mimic the growth and function of typical brain tissue. This achievement has significant implications for researchers studying the brain and working on treatments for neurodegenerative diseases such as Alzheimer's and Parkinson's disease. The new approach offers new avenues for drug testing and understanding brain development in neurological diseases. Unlike previous attempts, the team used a different 3D-printing approach. Rather than stacking layers vertically, they situated brain cells, neurons grown from induced pluripotent stem cells, in a softer “bio-ink” gel. This breakthrough could revolutionize the way we approach brain research and treatment. Read more about this groundbreaking discovery and its potential implications here: #neuroscience #brainresearch #3Dprinting #Alzheimers #Parkinsons #stemcells

I came across an interesting article about a recent breakthrough in neuroscience that I thought I’d share. The article highlights a new method for developing a lab-grown human brain organoid, essentially a mini human brain, using human stem cells instead of sarcomas derived from mice. By utilizing human fibronectin in the organoid, this model more accurately replicates brain function, development, and cellular interactions similar to those in a real human brain. This advancement allows scientists to study brain development in a more ethical manner, eliminating the need for animal tissue extraction altogether. The model’s effectiveness in replicating the human brain will enhance research into neurological disorders like Alzheimer’s, offering valuable insights into the complexities of the human brain. It can be difficult to be completely ethical in scientific research, so I find it very interesting that scientists were able to find an ethical alternative that is able to present more accurate data. I also find it interesting to think about how human stem cells can be used in future research to develop and give insight into the human brain, and potentially other organs. https://lnkd.in/gxjK-kaB

In a groundbreaking study reported by Jake Siegel from the Allen Institute, scientists have mapped out the progression of Alzheimer's disease at the cellular level, offering insights that could lead to new treatments. By analyzing over 3.4 million brain cells, the team identified that a specific type of neuron, the somatostatin-expressing inhibitory neuron, is one of the first to be lost in Alzheimer’s. This neuron loss occurs early in the disease, before symptoms like memory loss appear. Their research shows that Alzheimer's progresses in two phases: a slow, early disruption at the cellular level followed by a rapid decline in neurons that aligns with cognitive symptoms. The study, published in Nature Neuroscience, uses advanced technologies to trace how Alzheimer’s affects the brain over time. Researchers created a detailed "pathology clock" that maps how specific brain cells are lost or altered at different stages of the disease. Their findings suggest that targeting vulnerable cells like the SST neurons could be key to preventing the broader brain damage seen in Alzheimer’s. This research offers new potential for early intervention and highlights the need for treatments that focus on preserving these critical neurons rather than just addressing the well-known protein buildups associated with the disease. #AlzheimersResearch #BrainScience #Neuroscience #SSTNeurons #AlzheimersTherapies #MedicalInnovation #ENDALZ

#ARTxSCIENCE 2024:  Discover the power of #science combined with artistic expression and learn about the potential of stem cell research to transform the lives of people. Help up find a winner of the best fusion of #ARTxSCIENCE on https://lnkd.in/gAv_Yzyf ‘Flowering #Neurons in the #Brain Meadow’    Neurodevelopmental disorders present a significant healthcare burden worldwide and the treatments available focus on alleviating children’s symptoms. The goal of Maria Giovanna Garone and her team is to use #stemcells to generate #brainorganoids, complex 3D neural tissues that recapitulate aspects of #humanbrain development, and to investigate and find new therapeutic interventions for brain disorders of developmental origin.    The lack of effective therapies for neurodevelopmental disorders is largely due to the scarce understanding of human brain development. Brain organoids offer a great opportunity to understand how our brain is built and how alterations during this process cause neurodevelopmental disorders. This knowledge is fundamental for developing new effective therapies for these conditions.     The team have established advanced brain organoid models of the developing cerebral cortex, a region that is crucial for cognitive functions distinctive to humans. By using these models and cutting-edge technologies, we have begun to uncover developmental defects associated with complex neurodevelopmental disorders, highlighting the value of brain organoids to identify new therapies for these diseases.    This image shows 3D brain #organoid that model the Sotos syndrome (a developmental condition), displaying increased newborn neurons (green) originating from neural progenitors (red). Murdoch Children's Research Institute (MCRI) Faculty of Health and Medical Sciences, UCPH Leiden University Medical Center Novo Nordisk Foundation   Submission by Maria Giovanna Garone and Anna Leichter  Silvia Velasco Lab, #reNEWMelbourne, Australia 

🎓 Thrilled and honored to announce my participation in the EU Consortium BICEPTS (Beyond neuroInflammation: new Concepts to Elucidate the Peripheral immune system's vital role in Parkinson's disease) https://lnkd.in/dFB4JWts I'm joining a network of prominent PD researchers across Europe who are reshaping our understanding of the disease by exploring its crucial immune system component. At the heart of this initiative is our commitment to training the next generation of multidisciplinary Parkinson's disease researchers. BICEPTS is launching a network of 16 PhD positions across Europe, where young scientists will work at the intersection of #neuroscience, #immunology, #systemsbiology, and #artificialintelligence. I'll be supervising a #PhD project at the University of Athens, focusing on developing eXplainable #AI approaches for #metabolomics data analysis to uncover new insights into Parkinson's disease mechanisms. Our Athens-based PhD candidate will be part of a dynamic European network, collaborating across disciplines to transform PD research beyond traditional neuro-centric approaches. 🔍 Are you passionate about using XAI to combat Parkinson's disease? Full project description and application details are available at: https://lnkd.in/dPcdKgzp Early applications are encouraged. Feel free to repost! #ArtificialIntelligence #research #innovation #jobsearch #hiring

Neuroscientists at University of Galway have made an exciting discovery that could revolutionise stem cell based brain repair therapy for Parkinson's disease. Brain repair for Parkinson’s involves replacing the dead cells by transplanting healthy brain cells back into the brain. With recent advancements in regenerative medicine and stem cell technology, “induced stem cells” can now be used as a source of healthy cells. However, these skin cells-turned brain cells need to be transplanted into the brain at a very early stage in their conversion, and the vast majority of the cells do not continue to convert - once in the brain - into the mature cells that are required for the therapy to work. In work funded by the Michael J. Fox Foundation for Parkinson's Research (MJFF) and Science Foundation Ireland, published this week in the Journal of Neural Engineering, the team in the College of Medicine, Nursing and Health Sciences at University of Galway have shown that transplanting the immature cells in a collagen hydrogel dramatically improves both their survival and maturation in the brain. The new research aims to understand how the immune system in the brain reacts when cells are transplanted alone versus when they are transplanted in combination with the hydrogel. The full research study published in the Journal of Neural Engineering is available at https://ow.ly/sXQ950QT8y0 @scienceirl @MichaelJFoxOrg @NeuroscienceIRL @GalwayNeuro University of Galway - College of Medicine, Nursing and Health Sciences #UniversityofGalway #ForYouForTomorrow #research #ParkinsonsDisease #researchfunding #ScienceFoundationIreland #ParkinsonsResearch #michaeljfoxorg