A*STAR Research’s Post

#𝐂𝐄𝐃𝐇𝐔𝐂𝐏 𝐏𝐚𝐩𝐞𝐫 𝐌𝐨𝐦𝐞𝐧𝐭 📝 📢 Another publication from Research Centre for Human Development (CEDH) researchers is available online in the Trends in Food Science & Technology! The scientific article, ““Fucoidans: Exploring its neuroprotective mechanisms and therapeutic applications in brain disorders““, is signed by Patrícia Batista and Patrícia Oliveira-Silva, researchers of the Research Centre for Human Development (CEDH) and Sara A. Cunha, Tânia Ribeiro, Sandra Borges, Sara Baptista-Silva and Manuela Pintado, researchers at the Centre for Biotechnology and Fine Chemistry (CBQF) 🔑 Key findings: - Algae-derived compounds have shown possible therapeutic applications in brain disorders; - FUC has very interesting biological properties, highlighting its promising neuroprotective activity; - These molecules with neuroprotective properties can be used to improve neurodegeneration and neuroinflammation, representing both a challenge and an opportunity for the food and pharmaceutical industries. ℹ️ Discover all the conclusions here: https://swki.me/vDG6jXn8 #UniversidadeCatólicaPortuguesa #UCP #CatólicaPorto #EnsinoSuperior #universidade #faculdade #FaculdadeEducaçãoPsicologia #FEPUCP #CEDHUCP #CEDH

Te Kāuru — The Ferrier Research Institute scientists in collaboration with researchers in Singapore and at The University of Queensland have designed and synthesized a fully defined HS decasaccharide that can bind BMP-2 and subsequently enhance BMP-2-mediated bioactivity. Synthetic HS mimetics present an excellent opportunity to produce structurally defined, single entity molecules which emulate naturally-occurring sequences without inherent issues, such as limited supply, batch to batch variability, and unwanted side effects. The decasaccharide represents the first rationally designed HS aimed at promoting the actions of a clinically important growth factor. The study was published in Carbohydrate Polymers. https://lnkd.in/gUAPPfqs #carbohydrates #bonehealing #science #research #glycobiology

🌿 𝐒𝐌𝐋𝐒 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫 𝐨𝐟 𝐭𝐡𝐞 𝐖𝐞𝐞𝐤 #11: 𝐀𝐬𝐬𝐨𝐜. 𝐏𝐫𝐨𝐟. 𝐃𝐫. 𝐘𝐨𝐰 𝐘𝐨𝐨𝐧 𝐘𝐞𝐧  🔬 Our 11th featured researcher at the School of Medical and Life Sciences (SMLS), Sunway University, is Assoc. Prof. Dr. Yoon Yen Yow, a distinguished algae biotechnologist. Dr. Yow’s pioneering research focuses on the discovery and development of new compounds from algae as nutraceutical candidates for the prevention of neurodegenerative diseases. Her innovative work also explores the beneficial effects of algae in cosmeceuticals, along with their anti-microbial and anti-cancer properties. Dr. Yow's interests extend to the study of molecular phylogenetics and the genetic diversity of algae, as well as invasive Pomacea apple snails. Her contributions underscore the high value of algae as an economically important natural resource in Malaysia, where a remarkable 386 specific and intraspecific taxa have been recorded. Many of these algae have demonstrated potential with natural compounds possessing anti-ulcerogenic, anti-inflammatory, anti-microbial, anti-neurodegenerative, and gastroprotective properties, making them promising agents for antioxidant, chemotherapeutic, and anti-diabetic applications. Aligned with Sunway University’s commitment to the United Nations Sustainable Development Goals (UNSDGs), Dr. Yow is dedicated to discovering how algae can contribute to these goals, particularly in promoting well-being for all. Join us in celebrating Dr. Yow Yoon Yen’s outstanding contributions to algae biotechnology and her relentless pursuit of scientific excellence! 🌿🔬✨ #SMLSResearcherOfTheWeek #sunumedlifesc #SunwayUniversity #AlgaeBiotechnology #Nutraceuticals #SustainableDevelopmentGoals #SDGs

I am thrilled to share our latest publication in Acta Scientific Biotechnology, which explores the antibacterial efficacy of a crude compound extracted from Pseudomonas aeruginosa VSB3. This study offers promising insights into the potential therapeutic applications of marine-sourced bacteria in combating antibiotic-resistant pathogens. The findings underscore the significance of marine bioprospecting in the discovery of novel bioactive compounds with potent antibacterial properties.🌊 🔬Title: Isolation and Molecular Characterization of a Bacteria VSB3 from the Marine Environment and Its Antibacterial Activities 📚Published in: Acta Scientific Biotechnology (ASBT) 👩🔬Authors: Dr. kuthadi shanthi Kumari Vasavi Angeri Yogitha Bala Dugyala 📜Dive into the full article here: https://lnkd.in/gYH6g9j2 #MarineMicrobiology #AntibioticResistance #Biotechnology #ActaScientificBiotechnology #ResearchImpact

🚀 A Reminder of the Great Capabilities of #SPAchip® for Real-Time Cellular Analysis 🔬 At ARRAYS FOR CELL NANODEVICES, SL - A4CELL, we're excited to showcase #SPAchip, a cutting-edge tool that’s transforming research in areas like oxidative stress, cellular metabolism, and drug discovery. Here are four ways SPAchip can elevate your research projects: 1️⃣ Real-Time Monitoring: Track intracellular events like ROS and calcium levels in real-time within living cells, providing dynamic insights into cellular function. 2️⃣ Non-Invasive Detection: #SPAchip enters cells without impacting their viability, allowing for long-term, non-invasive studies. 3️⃣ Multiplexed Analysis: Simultaneously detect multiple metabolites, such as ROS, pH and calcium, in a single assay for more comprehensive data. 4️⃣ High Sensitivity & Precision: #SPAchip offers unparalleled sensitivity, giving researchers the precision needed to study complex biological pathways. Ready to take your research to the next level? Let’s explore how #SPAchip can add value to your projects! 🚀💡 #Research #CellBiology #Biotechnology #ROSDetection #Innovation

📢 𝗣𝘂𝗯𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗔𝗹𝗲𝗿𝘁! 📢 I’m thrilled to share that my latest research article has been published in the prestigious 𝗝𝗼𝘂𝗿𝗻𝗮𝗹 𝗼𝗳 𝗠𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗦𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗲 (𝗜𝗺𝗽𝗮𝗰𝘁 𝗙𝗮𝗰𝘁𝗼𝗿: 𝟰.𝟬) 📚, an 𝗘𝗹𝘀𝗲𝘃𝗶𝗲𝗿 publication indexed by 𝗦𝗰𝗼𝗽𝘂𝘀 🔍. 𝗧𝗶𝘁𝗹𝗲: 𝘚𝘺𝘯𝘵𝘩𝘦𝘴𝘪𝘴, 𝘊𝘩𝘢𝘳𝘢𝘤𝘵𝘦𝘳𝘪𝘻𝘢𝘵𝘪𝘰𝘯, 𝘉𝘪𝘰𝘭𝘰𝘨𝘪𝘤𝘢𝘭 𝘌𝘷𝘢𝘭𝘶𝘢𝘵𝘪𝘰𝘯, 𝘢𝘯𝘥 𝘔𝘰𝘭𝘦𝘤𝘶𝘭𝘢𝘳 𝘋𝘰𝘤𝘬𝘪𝘯𝘨 𝘚𝘵𝘶𝘥𝘺 𝘰𝘧 𝘚𝘰𝘮𝘦 𝘕𝘰𝘷𝘦𝘭 𝘗𝘩𝘦𝘯𝘰𝘹𝘺 𝘔𝘦𝘵𝘩𝘺𝘭 𝘓𝘪𝘯𝘬𝘦𝘥 1,2,3-𝘛𝘳𝘪𝘢𝘻𝘰𝘭𝘦 𝘋𝘦𝘳𝘪𝘷𝘢𝘵𝘪𝘷𝘦𝘴 𝘉𝘳𝘪𝘥𝘨𝘦𝘥 𝘸𝘪𝘵𝘩 𝘈𝘮𝘪𝘥𝘦 𝘍𝘶𝘯𝘤𝘵𝘪𝘰𝘯𝘢𝘭𝘪𝘵𝘪𝘦𝘴 𝘷𝘪𝘢 ‘𝘊𝘭𝘪𝘤𝘬 𝘊𝘩𝘦𝘮𝘪𝘴𝘵𝘳𝘺’ 𝘈𝘱𝘱𝘳𝘰𝘢𝘤𝘩 🧪🔬 𝗗𝗢𝗜: https://lnkd.in/dMAzpxnP 𝗣𝗗𝗙 𝗟𝗶𝗻𝗸: [Access the full article here] https://lnkd.in/d-uM5vbN Dive into the innovative world of phenoxy methyl linked 1,2,3-triazole derivatives 🌟, explore their synthesis, and discover their potential through detailed biological evaluations and molecular docking studies 🧬. This groundbreaking research harnesses the power of ‘click chemistry’ to bridge these novel compounds with amide functionalities ⚛️. The novel synthesized compounds show better antimalarial and antimicrobial activity compared to standard drugs 🌿💊. 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀 • Synthesis of novel phenoxy methyl 1,2,3-triazole derivatives with amide links via click chemistry. • Investigate ADME properties of novel phenoxy methyl triazole derivatives. • Examine antimalarial activity of phenoxy methyl triazole derivatives. • Assess antimicrobial effects of phenoxy methyl triazole derivatives. • Conduct molecular docking studies on phenoxy methyl triazole derivatives. We invite you to read and share your thoughts on this significant contribution to the field! 🌍📖 #Research #Publication #Science #MedicinalChemistry #JournalofMolecularStructure #Elsevier #Scopus #Innovation #1,2,3-Triazole #Phenoxymethyl #MolecularDocking #AntimalarialActivity #AntimicrobialActivity

I am pleased to share that our paper, "Identification of Allium cepa L. Derived Flavonoids as Potential Inhibitors of Human Serum Albumin Glycation in Diabetic Nephropathy: An In-Silico Analysis", has been officially published in IEEE Xplore. This project was a rewarding collaboration with Kanjam Manocha under the expert guidance of Dr. Navneeta Bharadvaja from the Department of Biotechnology, Delhi Technological University Delhi. Our study addresses complications of Type 2 diabetes, specifically Diabetic Nephropathy (DN), by exploring flavonoids derived from Allium cepa L. (Onion). Using in-silico molecular docking and ADME analysis, we identified compounds like quercetin and kaempferol as potential natural therapeutic agents. 🗓 Published in 2024 International Conference on Electrical Electronics and Computing Technologies (ICEECT), Sharda University   🔗 Full Paper Available Here: [IEEE Xplore](https://lnkd.in/g_3YZgG8) Looking forward to future discoveries in natural therapies for diabetes management! #Research #Biotechnology #IEEE #DiabetesResearch #NaturalTherapies #InSilicoAnalysis #Flavonoids #DiabeticNephropathy #DTU #ShardaUniversity #HealthcareInnovation

Cyclic IMS to "Dissect" n-1 Oligo Impurities🧬 Look at these IMS mobilograms! Shogo Omuro and Professor Satoshi Obika from Osaka University characterized n-1 oligo impurities using cyclic ion mobility #MassSpec. If you want an inside look at the "race track" these oligos were drifting through, have a look below at our for-display ion optics at the Waters Corporation Milford, MA campus (thanks Kevin Giles and James Langridge!). Omuro, Obika and co-workers used cyclic IMS to distinguish isomer impurities in antisense oligonucleotides (#ASO) and small interfering RNA (#siRNA). This resolution of n-1 isomer heterogeneity in the gas phase by their millsecond drift times is very neat, because it can potentially be applied to resolving the n-1 LC peak where these species often co-elute! 📔 Open Access Paper: https://lnkd.in/evRrqMPh Key Highlights: ✔ Innovative Approach: Cyclic IMS enables the separation of ions with identical m/z ratios based on structural differences, significantly improving the analysis of coeluting impurities in therapeutic oligos. ✔ Enhanced Detection: The study successfully characterized isomer impurities in patisiran and givosiran, revealing specific mobiligram patterns that traditional LC/MS methods struggle to distinguish. ✔ Potential Impact: This method provides a deeper understanding of impurity profiles. Neat thing to see - analytical advancements at the same pace of pharmacology breakthroughs! #AnalyticalChemistry #Biotech #Oligo #LifeatWaters

The Duality of Reactive Sulfur Species: Cellular Oxidants and Antioxidants A short oral contribution that will be presented by Christopher Switzer, University of Leicester, United Kingdom during #RedoxMedicine2024. This study explores the dual role of reactive sulfur species as both cellular oxidants and antioxidants. It enhances understanding of the complex role of sulfur species in cellular redox balance, contributing to the development of novel redox-based therapies. Join us on June 27-28, 2024 at Fondation Biermans-Lapôtre, Paris! 🔗 Selected Short Orals: https://lnkd.in/gypa9uFD. 🌐 Learn More: https://lnkd.in/dkNzFQZU. #RedoxMedicieSociety #RedoxMedicine2024 #biomarkers #redoxbiology #redox #antioxidants #innovation #oxidativestress #RedoxResearch

Congratulations to Fujihara Junki on defending his Master's thesis at the Freie Universität Berlin (supervisors: Martina Delbianco and Rainer Haag). #Sugars are versatile and complex building blocks. Junki exploited their ability to self-assemble, combining different #cellulose-based sugar molecules to form #nanocrystal structures (one of them shaped like a shish kebab 🍢). Potential applications of his findings range from drug delivery (using ad hoc sugars as carriers) to the creation of #biocompatible materials for medical purposes. "Supramolecular assembly of cellulose-based oligosaccharides" - M.A. Thesis #Glycobiology