Accessing Enamine PL's compound collection enables us to offer our customers greater flexibility and efficiencies in screening and target identification. Gary Clark, Director of Screening Technologies, Metrion Biosciences, said: “The combination of our specialist ion channel expertise with substantial HTS and hit-finding experience gives customers access to a dedicated team of drug discovery scientists, ensuring the correct strategic choices are made in compounds selected for screening. This additional access to the highest quality screening libraries from Enamine increases diversity and enables Metrion to maximise R&D budgets even more effectively.” Vladimir Ivanov, Executive Vice President, Enamine, commented: “Enamine is focused on delivering novel chemical compounds to support drug discovery. We are delighted that Metrion is adding access to our libraries to its HTS services offering. Enamine is also able to support subsequent steps of the discovery process including hit resupply, analoging from our in-stock and make-on-demand REAL libraries, and custom synthesis of advanced hits and leads. https://hubs.la/Q02sxfPL0 #screening #hts #highthroughputscreening #ionchannels #drugdiscovery #lifesciences #cro

Peptidic Macrocycles as Suitable Bioactive Scaffold for Targeted Protein Degradation with Jakob Fuhrmann from Genentech. The development of proximity-induced degraders still poses several challenges, including their relatively low cell-permeability, as well as high degree of conformational flexibility due to the presence of flexible linker elements. I will present our strategy to identify conformationally constrained macrocyclic degraders. I will further highlight our characterization cascade comprising ternary complex stabilization, as well as property-based optimizations to obtain in vivo bioactive compounds. https://lnkd.in/dpw8vaiv Save $150 with Discount code SPK150. #drugdiscoverychemistry

Boost your research this Black Friday with Peptify Labs! 🔬 😲 Save on top-tier research peptides and accelerate your discoveries. 💯 It's the perfect time to stock up on the essentials. Shop the sale now at peptifylabs.com! 🔗 Important Note: The peptides offered by PeptiFy Labs are intended exclusively for research purposes and should not be used for any other applications. #peptifylabs #researchpeptides #blackfridaydeal #blackfridaydealsonline  #biotechresearch #labessentials #researchdiscounts #scientifictools 

Q: What aspects affect the yield of de novo designed miniproteins when expressed in CHO vs. E. coli? A: The structural stability of miniproteins significantly affects their yield. Miniproteins with proper-folded, stable hydrophobic cores tend to express well in both E. coli and CHO systems. Additionally, E. coli is preferred for miniproteins with free cysteines designed for intracellular function, while CHO cells are better suited for those with disulfide bonds. For miniproteins used as building blocks for bsAbs, CHO is recommended to achieve optimal titers and yields. Want to learn more? Check out the FAQs at the end of our MiniProtein Line Service webpage: ▶️https://lnkd.in/gfZ9Hbd8 #CHOCells #ProteinProduction #BiologicsResearch #DrugDiscovery

Ensure your experiments are consistent and reliable with our high-purity Bovine Serum Albumin (BSA). Ideal for a wide range of applications, from immunoassays to cell cultures. Order today: https://lnkd.in/e4KeDBDJ #ResearchReliability #BSA #LifeScienceGroup #Biotech #LifeSciences #LaboratoryEssentials #ResearchMaterials #lifesciencegroup #lifescience

Struggling with media volume consistency in your cell plates? Well, it's #TechTuesday which means it's time for another technical tip from one of our scientists here at Axol to help you! Helena Raine, one of our Research Assistants at Axol that works on cellular differentiations and assays, shares her top technical tip to help you avoid media volume inconsistencies that can arise from evaporation that can take place during cellular incubation. Her top tip is to add some Phosphate-buffered saline on the outer plates beside the cells to stop evaporation in the outer well. This will help ensure that the volume in the plates remain s consistent. Media volume consistency is very important especially when performing compound screening as inconsistencies could adversely effect results. Additionally, evaporation from cell culture plates can cause culture problems since the medium components, can then reach concentrations that can become harmful to the cells. At Axol, we've spent more than a decade at the forefront of iPSC technology, adding to our bank of expertise in using iPSC-derived cells for drug discovery and research. As such, we're always ready to help. If you are interested in using human iPSC-derived cells in your work, contact us at operation@axolbio.com. #TechTuesday #iPSCs #StemCells #Microglia

Cell Culture Scientists Tech Tuesday or Should I say “Tuesday Tip” Well, it's #TechTuesday which means it's time for another technical tip from one of our scientists here at Axol to help you! Helena Raine, one of our Research Assistants at Axol that works on cellular differentiations and assays, shares her top technical tip to help you avoid media volume inconsistencies that can arise from evaporation that can take place during cellular incubation. Her top tip is to add some Phosphate-buffered saline on the outer plates beside the cells to stop evaporation in the outer well. This will help ensure that the volume in the plates remain s consistent. Media volume consistency is very important especially when performing compound screening as inconsistencies could adversely effect results. Additionally, evaporation from cell culture plates can cause culture problems since the medium components, can then reach concentrations that can become harmful to the cells. Big THANKS Helena #cellculture #lifesciences #organonchip

Struggling with media volume consistency in your cell plates? Well, it's #TechTuesday which means it's time for another technical tip from one of our scientists here at Axol to help you! Helena Raine, one of our Research Assistants at Axol that works on cellular differentiations and assays, shares her top technical tip to help you avoid media volume inconsistencies that can arise from evaporation that can take place during cellular incubation. Her top tip is to add some Phosphate-buffered saline on the outer plates beside the cells to stop evaporation in the outer well. This will help ensure that the volume in the plates remain s consistent. Media volume consistency is very important especially when performing compound screening as inconsistencies could adversely effect results. Additionally, evaporation from cell culture plates can cause culture problems since the medium components, can then reach concentrations that can become harmful to the cells. At Axol, we've spent more than a decade at the forefront of iPSC technology, adding to our bank of expertise in using iPSC-derived cells for drug discovery and research. As such, we're always ready to help. If you are interested in using human iPSC-derived cells in your work, contact us at operation@axolbio.com. #TechTuesday #iPSCs #StemCells #Microglia

Challenges with Host Cell Protein Analysis? In this recent paper from scientists at Merck, they utilize the Evosep One coupled to a Bruker timsTOF Pro 2 to overcome the challenges of host cell protein (HCP) analysis. By leveraging diaPASEF, they were able to reveal the presence of more than 600 additional HCPs previously missed by DDA PASEF. In addition to improved characterization of the sample, they were able to increase throughput and eliminate carryover! Taku Tsukidate, Alyssa Stiving, Shannon Rivera, Ansuman Sahoo, Sri Madabhushi, Xuanwen Shawn Li Take a look at the full manuscript 👇 👇👇 https://lnkd.in/e4QkQSyy To learn more about the Evosep One, visit our website evosep.com or reach out to me for additional information. #Evosep, #Bruker, #Hostcellproteins, #hcp,

Struggling with media volume consistency in your cell plates? Well, it's #TechTuesday which means it's time for another technical tip from one of our scientists here at Axol to help you! Helena Raine, one of our Research Assistants at Axol that works on cellular differentiations and assays, shares her top technical tip to help you avoid media volume inconsistencies that can arise from evaporation that can take place during cellular incubation. Her top tip is to add some Phosphate-buffered saline on the outer plates beside the cells to stop evaporation in the outer well. This will help ensure that the volume in the plates remain s consistent. Media volume consistency is very important especially when performing compound screening as inconsistencies could adversely effect results. Additionally, evaporation from cell culture plates can cause culture problems since the medium components, can then reach concentrations that can become harmful to the cells. At Axol, we've spent more than a decade at the forefront of iPSC technology, adding to our bank of expertise in using iPSC-derived cells for drug discovery and research. As such, we're always ready to help. If you are interested in using human iPSC-derived cells in your work, contact us at operation@axolbio.com. #TechTuesday #iPSCs #StemCells #Microglia