Back Bay Life Science Advisors’ Post

#Webinar now available on demand! mRNA Characterization - from 5’ cap to poly (A): what IPRP-LC–MS can tell you #mRNA is a biotherapeutic modality primarily used in #vaccines and undergoes a complex manufacturing process involving #invitrotranscription. In order to ensure the desired product quality of mRNA therapeutics, critical quality attributes must be maintained within appropriate limits. Therefore, the implementation of robust analytical methods is crucial for making quality decisions. Phenomenex’s Roxana Eggleston-Rangel (Advanced Workflows Applications Manager, Pharma & Biopharma) introduces a novel #mRNAcharacterization workflow that yields mRNA molecules exceeding 1,000 nucleotides in length, with a 5' cap and a poly (A) tail Watch at your convenience below:

Thoughts on this? >> Australian RNA manufacturer launches; Forge Biologics’ CEO steps down >> Comment below! >>> lqventures.com #strategy #competitiveintelligence #marketing #biotech #healthcare #pharmaceutical #pharma #productmarketing

Just a few days away from the 21st BioPharma Drug Discovery Nexus Conference🚀 Looking forward to our panel on 'Reducing Biologics Attrition in the Clinic Through Efficient Discovery Processes.' It’s going to be a fantastic opportunity to hear from the best minds in the industry! Can’t wait to dive into these discussions! 💡 #BioPharma #DrugDiscovery #Biologics #Innovation #NexusConference

🔬🧬 The Future of Biologics Research! 🧬🔬 Join us on 18 November 2024 from 13:30 - 14:00 at the Antibody Therapeutics Xchange - Brussels for an exclusive Spotlight Presentation on "Innovative Solutions Set New Standards in Quality & Speed for Biologics Research." 🚀 In today’s fast-paced biologics development, having flexible, end-to-end solutions is essential to drive efficiency. This session will dive into our integrated modular services—from antibody discovery 🧪 and protein engineering 🧫 to production ⚙️ and in vitro & in vivo testing🔬—that streamline the research process. 🌟 Key topics include: 🟡 Tailored services for each stage of antibody drug development 🧬 🟡 Advanced high-titer expression platform enabling high yields in less time 🧪 🟡Innovative bispecific antibody production strategies for >98% heterodimer purity across diverse formats ⚗️ 🧪 Jiansheng Wu, Head of CRO Services, Vice President at WuXi Biologics will share his deep insights and extensive experience, accumulated through over 50 drug development projects and 15 years at Genentech. Register now for FREE to stay ahead in biologics research innovation: https://lnkd.in/e5Vrkbdj Only available for Senior Scientists and above, from Bio and Pharma companies, with a drug pipeline. 💊 #BiologicsResearch #AntibodyTherapeutics #ProteinSciences #BiologicsDevelopment #AntibodyEngineering #WuXiBiologics #DrugDevelopment #AntibodyDiscovery #InnovativeSolutions #CMC #ProteinProduction #Biopharma #Biotech #LifeSciences #TherapeuticDiscovery #ScientificRoundtable #hubXchange #Xchanges #Roundtable #FreePass #RegisterNow #ComplimentaryPass

🔬 𝐄𝐱𝐩𝐥𝐨𝐫𝐢𝐧𝐠 𝐀𝐧𝐚𝐥𝐲𝐭𝐢𝐜𝐚𝐥 𝐓𝐞𝐜𝐡𝐧𝐢𝐪𝐮𝐞𝐬 𝐟𝐨𝐫 𝐦𝐑𝐍𝐀 𝐂𝐡𝐚𝐫𝐚𝐜𝐭𝐞𝐫𝐢𝐳𝐚𝐭𝐢𝐨𝐧 🔍💡 The biopharmaceutical industry is advancing, and the demand for robust analytical methods for mRNA products is crucial. A recent study from Regeneron evaluated various capillary electrophoresis-based methods for their effectiveness in assessing the purity and stability of in vitro transcribed mRNA. This comparative analysis sheds light on the strengths and limitations of each method, guiding us toward more efficient and accurate assessments in this critical area. 🎯 𝐊𝐞𝐲 𝐓𝐚𝐤𝐞-𝐀𝐰𝐚𝐲𝐬: ⚗️ SCIEX RNA 9000 Purity and Integrity Kit: Highest selectivity and resolving power, ideal for in-depth sample characterization. 🧬 Agilent Technologies RNA 6000 Nano Kit, Revvity RNA Reagent Kit, and Agilent Technologies HS RNA Kit: Faster analysis times, suitable for high-throughput applications. 🔍 Balancing resolution, analysis time, and throughput is key for selecting the right analytical method. #Biopharmaceuticals #mRNA #AnalyticalChemistry #CapillaryElectrophoresis #PharmaceuticalAnalysis #LabTech #ScientificResearch Prerana Mantri, Bindiya Juneja, Steven Henderson, Evan Koufos, Youmi Moon, Daniel Dayeh, Deanna Di Grandi, Yue Fu, Kathir Muthusamy, Peter Ihnat, Nisha Palackal, Erica P.

BiaB is a modular, integrated, and automated RNA-micro factory that enables the processing of various RNA-based products, including messenger RNA (mRNA) and self-amplifying RNA (saRNA), and has the potential to significantly reduce the time it takes to bring RNA therapies to market, according to officials at Quotient. #JLLLifeSciences #biotech #pharma #medtech

Are you joining the Conversation on Multispecific Therapeutics?🔬🚀 Don't miss out on the roundtable discussion, "Challenges Facing the Development and Production of Multispecific Therapeutics," on 18 Nov 2024, from 17:05 - 18:05 at the Antibody Therapeutics Xchange - Brussels! 👥 Secure your spot now and be part of this essential discussion! 📝 https://lnkd.in/eQ9rs5u5 🧬 Key Discussion Points: 🧪 Do complex sequences impact titer, assembly, and purification? 🧬 Off-target effects vs. target affinity, specificity, and patient safety — what's the balance? 🧫 Are standard analytics platforms sufficient for complex molecule formats? 🔬 How do you adapt functional assays for multiple target modes of action? 🧪 Phase-specific approaches for complex mechanisms and functional assay timing. Featuring Sabrina Vollers, PhD, Director, Head of Drug Product and Analytical Development - Ichnos Glenmark Innovation who will share her expertise in bi- and multispecific antibody therapeutics. 🧑🔬 Only available for Senior Scientists and above, from Bio and Pharma companies, with a drug pipeline. 💊 #BiSpecifics #Multispecifics #AntibodyTherapeutics #PharmaInnovation #DrugDevelopment #Biotech #Immunotherapy #AnalyticalDevelopment #Xchange #PharmaScience #RND #ScientificRoundtable #hubXchange #Xchanges #Roundtable #FreePass #RegisterNow #ComplimentaryPass

🧑🔬 A huge shoutout to our partners for their incredible support of the European Antibody Therapeutics Xchange 2024! 🌟 Your commitment to advancing antibody therapeutics is invaluable, and we’re excited to collaborate in pushing the boundaries of healthcare innovation.🧫 🧬 🥇 Our Partners: 🟡 Bio-Rad Laboratories 🟡 WuXi Biologics 🟡 evitria AG 🟡 IPA (ImmunoPrecise Antibodies) 🟡 Nostrum Biodiscovery 🟡 YUMAB GmbH 🟡 Sunresin New Materials Co. Ltd. 🟡 VERAXA Biotech GmbH 🟡 Synexa Life Sciences 🟡 Catalent Pharma Solutions 🟡 IQVIA Laboratories – In Vitro Immunology Haven’t registered yet? There’s still time to secure your COMPLIMENTARY pass and be part of this ground-breaking event. Join us in shaping the future of medicine! REGISTER FOR FREE: https://lnkd.in/eS4mpGqV Only available for Senior Scientists and above, from Bio and Pharma companies with a drug pipeline. 💊 #AntibodyTherapeutics #Biopharma #HealthcareInnovation #EU2024 #LifeSciences #MedicalInnovation #BiotechInnovation #FutureOfMedicine #Pharma #EUEvents #PartneringForSuccess #TherapeuticInnovation #AntibodyEngineering #BiotechnologyLeadership #DrugDevelopment #HealthcareSolutions #ClinicalResearch #PharmaceuticalScience #PrecisionMedicine #LifeScienceCommunity #BiotechCommunity #HealthcareEcosystem #BiotechResearch #AntibodyDiscovery #NextGenTherapeutics #PharmaInnovation #hubXchange #Xchanges #Roundtable #FreePass #RegisterNow #ComplimentaryPass

Algorae Pharmaceuticals Ltd (#ASX Code: #1AI) #ASXnews - Positive results from AI-116 in vitro studies. • Pre-clinical data demonstrates neuroprotective effect of AI-116, exceeding that for the existing FDA registered drug for dementia, Donepezil (originally marketed as Aricept). • Cell viability increased by 20.1% for AI-116 versus 2.1% for Donepezil, in pre-clinical studies. • Results demonstrate synergistic method of action within AI-116. • RNA sequencing analysis to commence to further assess AI-116, including for neuroinflammation which plays a multifaceted role in the pathogenesis of dementia.  #ai #artificialintelligence #biotech #pharmaceutical