Basic and Clinical Neuroscience Journal’s Post

BrainInsight: First reliable #NonInvasive detection of elevated intracranial pressure?   Evaluation of the effectiveness of Transcranial Transmission Ultrasound #TTUS non-invasively detecting elevated intracranial pressure #ICP in unconscious traumatic brain injury #TBI patients.  🔎 𝐊𝐞𝐲 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬: 1️⃣ A proof of concept study explored using Transcranial Transmission Ultrasound for non-invasive ICP measurement in patients with traumatic brain injuries 2️⃣ The research is based on analyzing brain pulsatility using TTUS and machine learning. Data were collected from 25 patients with severe TBI. 3️⃣ The automated TTUS analysis effectively identified ICP values above 15 mmHg with 100% sensitivity and 47% specificity. 4️⃣ TTUS can reliably rule out high ICP values >15 mmHg, indicating patients who may need immediate imaging or intervention.   📚 𝐒𝐭𝐮𝐝𝐲 𝐃𝐞𝐭𝐚𝐢𝐥𝐬: ⏹ Title: Transcranial transmission ultrasound for reliable non-invasive exclusion of intracranial hypertension in traumatic brain injury patients ⏹ Authors: Sandro M. Krieg, Maximilian Schwendner, Leonie Kram, Haosu Zhang, Raimunde Liang, Chiara Negwer, Bernhard Meyer ⏹ Journal: Journal of Neurotrauma ⏹ DOI: 10.1089/neu.2024.0027    We invite experts in neurology and neurosurgery to comment: How do you think this model will impact your practice and patient care? Let's discuss below. 💬🧠

𝐍𝐨𝐧-𝐢𝐧𝐯𝐚𝐬𝐢𝐯𝐞 𝐛𝐫𝐚𝐢𝐧 𝐦𝐨𝐧𝐢𝐭𝐨𝐫𝐢𝐧𝐠 𝐟𝐨𝐫 𝐦𝐚𝐧𝐚𝐠𝐢𝐧𝐠 𝐚𝐜𝐮𝐭𝐞 𝐛𝐫𝐚𝐢𝐧 𝐢𝐧𝐣𝐮𝐫𝐲 (𝐀𝐁𝐈) Neurological assessment in ABI is critical but often challenging, especially during the acute phase or with sedated patients. While invasive methods are the gold standard, non-invasive monitoring (NIM) is rapidly transforming neurocritical care. 🚀 These innovative tools provide a real-time window into intracranial physiology, detecting small changes that can save lives. Here’s a quick look at some of the key NIM techniques: 🔹 𝐁𝐫𝐚𝐢𝐧 𝐔𝐥𝐭𝐫𝐚𝐬𝐨𝐮𝐧𝐝 (𝐁𝐔𝐒): A repeatable, bedside tool for real-time assessment of cerebral hemodynamics, ICP changes, emboli, and even brain death. 🔹 𝐄𝐄𝐆 & 𝐐𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐄𝐄𝐆 (𝐐𝐄𝐄𝐆): Vital for identifying seizures and brain function patterns. QEEG accelerates analysis and supports rapid decision-making. 🔹 𝐀𝐮𝐭𝐨𝐦𝐚𝐭𝐞𝐝 𝐏𝐮𝐩𝐢𝐥𝐥𝐨𝐦𝐞𝐭𝐞𝐫: An objective measure of brainstem function. The Neurological Pupil index (NPi) is a reliable marker for elevated ICP and prognosis. 🔹 𝐒𝐤𝐮𝐥𝐥 𝐌𝐢𝐜𝐫𝐨𝐝𝐲𝐧𝐚𝐦𝐢𝐜𝐬 𝐒𝐞𝐧𝐬𝐨𝐫 (𝐁4𝐂): A cutting-edge technique assessing intracranial compliance (ICC) by tracking cranial movements—providing real-time ICP surrogate waveforms. 🔹 𝐍𝐞𝐚𝐫-𝐈𝐧𝐟𝐫𝐚𝐫𝐞𝐝 𝐒𝐩𝐞𝐜𝐭𝐫𝐨𝐬𝐜𝐨𝐩𝐲 (𝐍𝐈𝐑𝐒): Measures brain oxygenation but comes with extracranial signal challenges in ABI patients. Each technique has its strengths and limitations, but together they create a powerful multimodal approach to neurological monitoring. 🧩 By combining NIM tools, we can: ✅ Detect complications early ✅ Intervene faster ✅ Improve patient outcomes Whenever invasive monitoring can be avoided, non-invasive methods offer a safer, continuous, and actionable alternative—helping clinicians intervene faster and ultimately improve patient outcomes. 🚑 𝐖𝐞 𝐚𝐭 𝐒𝐨𝐧𝐨𝐯𝐮𝐦 are also pushing boundaries with our non-invasive technology called TTUS® - transcranial transmission ultrasound - to enable faster intervention and better outcomes, emphasizing the importance of early, accurate findings in neurocritical care! 💡 How do you see non-invasive monitoring reshaping the future of ABI management? Let’s discuss! Get a complete overview in this article: https://lnkd.in/gg7AdPVm #NeurocriticalCare #NonInvasive #BrainMonitoring #AcuteBrainInjury #TTUS

Dazzling Dilemmas: Differentiating Intracranial Masses Using MR Imaging Melissa van Kuik, M.D.; et al. (Department of Neurology, OLVG, Amsterdam, Netherlands)   It is not uncommon for intracranial space-occupying lesions (SOLs) to be identified during the diagnostic workup in patients with focal neurological deficits. The differential diagnosis of intracranial SOLs includes conditions such as abscesses, hemorrhage, meningiomas, gliomas, lymphomas, and cerebral metastases. The therapeutic approach to these diagnoses varies greatly. Therefore, accurately distinguishing between these conditions is paramount. The authors elaborate on the differentiation between cerebral abscesses, gliomas, and cerebral metastases using different #MRI sequences. Techniques such as DWI and perfusion imaging can provide information about various aspects of the SOL and the adjacent brain tissue, helping to distinguish between these conditions.   In practice, however, these scanning techniques still do not fully guarantee a correct diagnosis. A more detailed analysis of the peritumoral region or the use of other techniques such as MR spectroscopy may potentially lead to further improvement of the accuracy. Learn more at https://lnkd.in/euRbCHks   #magnetomworld #Neuroimaging Siemens Healthineers    Liza Gelissen, M.D. (Amsterdam UMC, Netherlands); Gwendolyn Vuurberg, M.D., Ph.D. (Rijnstate Hospital, Arnhem, Netherlands); Compendium Geneeskunde

🚨 New Publication Alert 🚨 I’m excited to share my latest research, "Endovascular Treatments, Predictors, and Outcomes of Cerebral Aneurysm: A Systematic Review," now published in the journal Romanian Neurosurgery! Daniel Encarnación-Santos MD Bipin Chaurasia Ismail Bozkurt and others. In this study, we conducted a thorough systematic review to evaluate the current landscape of endovascular treatments for cerebral aneurysms. This work consolidates key insights on: - Predictive factors for successful outcomes and complications - Advances in endovascular techniques and devices - Long-term outcomes of these treatments, helping clinicians make informed decisions The importance of this review lies in its potential to guide clinical practice, optimize patient care, and improve safety in managing cerebral aneurysms—an area of increasing relevance as endovascular interventions become more common. I hope this work contributes to ongoing research efforts and serves as a valuable resource for healthcare professionals in the field of neurology, interventional radiology, and beyond. Feel free to check out the full article for in-depth insights. Your thoughts and feedback are welcome! https://lnkd.in/eYxun9pk #CerebralAneurysm #EndovascularTreatment #Neurosurgery #InterventionalRadiology #MedicalResearch #HealthcareInnovation #PatientCare #SystematicReview

So glad we’re measuring the abilities/limitations of POC MRI; can make a legitimate use-case in acute neurology. Forget the big magnet—let’s compare the tech within its potential use, POC MRI sensitivity is notably superior to NCCT (it’s been shown that the NCCT sensitivity for ischemic strokes older than 12 hours is only ~16%); NCCT’s value is in ruling-out ICH (for this time window >84% sensitivity). And, considering most systems’ protocol, better imaging for both is important, because many patients are denied opportunity for acute intervention if LKW unobtainable and/or >12-24hrs. How about this option—taking advantage of both their strengths: For clinical diagnosis of AIS and presumed onset<72hrs (most folks in the ED) but “Inaccurate Last Known Well” (ILKW, LKW>24hrs or no historical context), 1. NCCT first, 2. on return to ED into dedicated POC MRI. 3. If no T2 on FLAIR give systemic rapid fibrinolytic. 4. Does DWI characteristics suggest endovascular intervenable pathology? Decide to go to lab. With mobile PACS platforms, eg. VIZ.AI & RAPID, now able to view MRI, decision making with this setup could be in real time and easily incorporated in all thrombectomy capable centers. If anyone else has POC-MRI in their ED and want to write this up with me, give me a call 🙌🏽

🧠 Exploring Frontiers in Trigeminal Neuralgia Treatment 🧠 1.0 #CME Trigeminal neuralgia (TN), a condition notorious for causing severe facial pain, has puzzled clinicians and researchers alike. A groundbreaking study led by Sarasa Tohyama, Matthew R Walker, Jia Zhang, Joshua C Cheng, Mojgan Hodaie offers insights into why some patients benefit from neurosurgical treatments while others do not. 🔬 Using diffusion tensor imaging (DTI), researchers analyzed the brainstem trigeminal fibers of 98 TN patients. Their findings reveal that microstructural abnormalities in these fibers may predict surgical outcomes. This study highlights the potential of DTI as a noninvasive tool to identify treatment responders and nonresponders, providing a personalized approach to managing TN. 👉 Key Points: DTI can serve as a biomarker for surgical outcomes in TN. Microstructural differences in trigeminal fibers correlate with treatment effectiveness. The study included patients with classical TN, TN secondary to multiple sclerosis, and TN associated with a pontine lesion. https://lnkd.in/d4gu56Nr #PhysicianInsights #MedicalPractice #DoctorsUpdate #Neurology #MedicalResearch #CME

🎉 Exciting Milestone in Parkinson's Disease Research! 🎉 We’re thrilled to announce that the #PARKEO2 clinical trial has successfully completed its enrollment phase ahead of schedule! 🚀 This groundbreaking study, led by Professor Emmanuel Cuny at the Bordeaux University Hospital (CHU de Bordeaux), is focused on improving surgical treatments for Parkinson's disease through cutting-edge technologies like deep brain stimulation (#DBS) and AI-powered neurosurgical planning. 🧠💡 Special thanks to our amazing teams and partners at the APHM (Assistance Publique - Hopitaux de Marseille), Nice University Hospital (Centre Hospitalier Universitaire de Nice (CHU de Nice), and the Hospices Civils de Lyon (Hospices Civils de Lyon - HCL) for their vital roles in this success. 🙏 At RebrAIn, we continue pushing the boundaries of healthcare innovation, using AI and machine learning to deliver more personalized and precise treatments to patients worldwide. 🌍🔬 Read the full press release to learn more about how PARKEO2 is making waves in neurosurgery and Parkinson’s care. #ParkinsonsDisease #Neuromodulation #ClinicalTrials #RebrAIn #HealthcareInnovation #PrecisionNeurosurgery #MachineLearning https://lnkd.in/dPiYdNAa

It would be such advancement to have the portable MRI in the ED to be able to diagnosis and treat conditions more quickly, accurately, and less traumatically.

#multiplesystematrophy #externalanalsphincter #electromyography #neurophysiology External anal sphincter electromyography in multiple system atrophy: implications for diagnosis, clinical correlations, and novel insights into prognosis https://lnkd.in/g2yMANzC Università di Pavia Multiple system atrophy is a sporadic, progressive, adult-onset, neurodegenerative disorder characterized by autonomic dysfunction symptoms, parkinsonian features, and cerebellar signs in various combinations. An early diagnosis of multiple system atrophy is of utmost importance for the proper prevention and management of its potentially fatal complications leading to the poor prognosis of these patients. The current diagnostic criteria incorporate several clinical red flags and magnetic resonance imaging markers supporting diagnosis of multiple system atrophy. Nonetheless, especially in the early disease stage, it can be challenging to differentiate multiple system atrophy from mimic disorders, in particular Parkinson’s disease. Electromyography of the external anal sphincter represents a useful neurophysiological tool for differential diagnosis since it can provide indirect evidence of Onuf’s nucleus degeneration, which is a pathological hallmark of multiple system atrophy. In this review, after a brief overview of the electrophysiological methodology, we first aimed to critically analyze the available knowledge on the diagnostic role of external anal sphincter electromyography. We discussed the conflicting evidence on the clinical correlations of neurogenic abnormalities found at external anal sphincter electromyography. Finally, we reported recent prognostic findings of a novel classification of electromyography patterns of the external anal sphincter that could pave the way toward the implementation of this neurophysiological technique for survival prediction in patients with multiple system atrophy.

🏥 GE HealthCare launches Signa Magnus magnetic resonance scanner Signa Magnus, pending US Food and Drug Administration (FDA) 510(k) approval, is designed to expand MR research in complex imaging procedures in neurology, oncology and psychiatry. US-based GE HealthCare said that the device addresses challenges conventional whole-body MR systems pose. The MR scanner advances the medical technology company’s vision for an advanced 3.0T MR imaging system for head-only neurological and oncological research imaging. The system is engineered to provide a thorough exploration of brain microstructure, microvasculature, and function. Through Signa Magnus, GE HealthCare plans to empower neuroscientists, neurologists, neuroradiologists, and oncologists to advance the diagnosis, comprehension, and treatment of complex disorders. GE HealthCare MR CEO Kelly Londy said: “With Signa Magnus, we are not just exploring the possibility of providing the tool; we are setting new benchmarks in medical research and future clinical patient care. “This innovation underscores our commitment to R&D and our collaborations with academia, pushing the boundaries of what’s possible in MR imaging. “The potential impact of Signa Magnus on patient outcomes and our understanding of the human brain is profound.” Read more online: https://lnkd.in/evB6yrnB 📰 Follow Medical Device Developments to receive the latest medical device news daily and to subscribe to our weekly newsletter #MedicalDeviceDevelopments #gehealthcare #mrscanner #imaging