BetterHealthGuy.com’s Post

We are thrilled to announce the release of a new protein structure in the Protein Data Bank, created in collaboration with our partners at ITALFARMACO S.P.A. The structure, 9EU0, provides valuable insights into the mechanism of HDAC6 inhibition by DFMO compounds, showcasing the importance of structural biology in advancing our understanding of key molecular interactions and their implications for drug discovery. Explore the structure and learn more about its significance: https://lnkd.in/eZxPkHUh #drugdiscovery #structuralbiology #protein #crystallography #hdac6 #inhibition

#Servicebio cell culture series star products, make your cell experiment more safe and efficient. #newarrival #Cellculture #CryoGenic #cellproducts #cellsolutions #cellware #plastic #molecularbiology

Have you heard of #AssayGenie ‘s recent launch? A 3D Organoid Cell Viability Assay which is a 1-step assay validated on Apical-out airway organoids & neuronal organoids. Reach out to our technical team for any inquiries. #3dcellculture #biotech #researchanddevelopment #lifescience

From their abstract: In this context, the discovery of novel CRBN ligands is an important area of ongoing research that holds promise to expand the scope of proteins that can be targeted through this mode of action. Herein, we describe the synthesis and evaluation of CRBN ligands featuring heteroaryl glutarimide and dihydrouracil scaffolds. We identified a subset of heteroaryl glutarimides exhibiting potent CRBN binding and increased chemical stability in cell culture media compared with traditional immunomodulatory drugs (IMiDs). This indicates that the scaffolds described herein could become useful starting points for the discovery of novel molecular glue degraders.

Exploring Multi-ligand Docking for the identification of the most promising ligand interactions with a specific target protein. The screening of compound libraries is accelerated leveraging the roubust algorithms of computational docking applications. This approach reduces heavy reliance on wet-lab experiments enabling faster development of new therapeutics with great precision. Identification of active sites using 3D grids and docking simulations for ligand pose preparation, significantly enhance the docking workflow. #multiliganddocking #drugdiscovery #medicinalchemistry #AutoDoc #Enzyme #Ligand #PyRx #vina #computationalbiology #CCCU #LJMU #LSTM

Miniproteins are an exciting therapeutic modality able to target large protein-protein interaction interfaces that have traditionally been challenging for small molecule drugs. https://lnkd.in/ey_3xmbC Backbone modification has proven to be a useful tool for increasing the proteolytic stability of mini-proteins while effectively mimicking their tertiary structures and biological activity. However, the orthogonality of the effects of factors such as sequence position, backbone modification, and sidechain modification on thermal stability have not been extensively investigated. https://lnkd.in/ezhMfg2S A new paper from the W. Seth Horne Lab sought to address this limitation by incorporating Cα methylation at various positions in a natural α-helical mini-protein, showing that tandem sidechain retention and backbone modification in alpha helices had a synergistic stabilizing effect. 𝑰𝒏𝒕𝒆𝒓𝒑𝒍𝒂𝒚 𝒃𝒆𝒕𝒘𝒆𝒆𝒏 𝑪α 𝑴𝒆𝒕𝒉𝒚𝒍𝒂𝒕𝒊𝒐𝒏 𝒂𝒏𝒅 𝑪α 𝑺𝒕𝒆𝒓𝒆𝒐𝒄𝒉𝒆𝒎𝒊𝒔𝒕𝒓𝒚 𝒊𝒏 𝒕𝒉𝒆 𝑭𝒐𝒍𝒅𝒊𝒏𝒈 𝑬𝒏𝒆𝒓𝒈𝒆𝒕𝒊𝒄𝒔 𝒐𝒇 𝒂 𝑯𝒆𝒍𝒊𝒙-𝑹𝒊𝒄𝒉 𝑴𝒊𝒏𝒊𝒑𝒓𝒐𝒕𝒆𝒊𝒏 (2025)  - https://lnkd.in/eZgCkWUB Click here for our lab's last paper on miniprotein design, and please congratulate Thomas Harmon and Yuhan Lin on the great work: https://lnkd.in/enNkyQ3n #ProteinDesign #Peptides #ProteinEngineering #Foldamers #Miniproteins

A new study provides a comprehensive evaluation of current LC3/GABARAP ligands, revealing that many do not interact with their intended targets. Through in silico docking and large-scale crystallographic fragment screening, the researchers identified that most fragments bind to the HP2 pocket of the LC3-interacting region, indicating favorable druggability of this site. A great series of findings that offer validated ligands for future autophagosome tethering compound (ATTEC) development and advance targeted protein degradation strategies. Read the full article here: https://lnkd.in/d4HsQxfA #Autophagy #ProteinDegradation #LC3 #GABARAP #DrugDiscovery #OpenScience

I am pleased to share that our work on the Ingested Polystyrene Micro-Nanoplastics Increase the Absorption of Co-Ingested Arsenic and Boscalid in an In Vitro Triculture Small Intestinal Epithelium Model has been successfully published in Microplastics. https://lnkd.in/e-yzuNa6

Interaction of a new triazole compound with serum albumins and bromelain... Application of fluorescence in drug discovery... #medicinalchemistry #drugdesign #docking #synthesis #fluorescence #proteins

TRIM oligonucleotide codon design is crucial for lead candidate identification as it enables precise control over codon variability in libraries.