BioInsights’ Post

Did you know that over 90% of Earth's microbes remain uncharacterized or undiscovered? Does this pique your scientific curiosity? Microbial communities are pivotal to our health and harbor vast potential for future breakthroughs in medicine, biotechnology, and drug development. We invite you to participate in this insightful webinar with David Gomez Varela to learn about the fascinating world of Metaproteomics. When: April 16, 2024, 10:00 - 11:00 am CEST Follow the link to register! You will have a chance to discover: 1. The unique role of Mass Spectrometry-based proteomics in unlocking the functional capabilities of microbiomes (aka. Metaproteomics) and its profound impact on understanding health and disease. 2. How we use the groundbreaking capabilities of the timsTOF Ultra mass spectrometer to reach unprecedented depth, sensitivity, and quantitative analysis of complex microbiome samples. 3. How we push the boundaries of sensitivity to achieve to pave the way to discover new biology. #Metaproteomics #microbiome #timsTOFUltra #genuine #science #Bruker #Proteomics #sensitivity #actual #quantumleap2024

Not only MALDI (heard about our Biotyper? ) can be successfully implemented in microbiology ;)

Crazy coincidence meeting Dr. Gordon Vansant, PhD --4 times in 3 days!! He's a top Geneticist in advanced translational/innovative molecular testing and clinical research. We hit it off and are now joking about launching a company together. Combining breakthrough scientific innovations and strategic branding – what could go wrong? 😂 #GeneticsMeetBranding #ConferenceCoincidences #BIO24 #NetworkingWins #DynamicDuo #InnovationInAction #LuminoDx #AddisonWhitney #LoveYaGordo!!

My work with Profs Jorge Júlvez and Steve Oliver at the Cambridge Systems Biology Centre during my undergraduate years, continued by Jorge Lázaro at the University of Zaragoza, has been published as a preprint: https://lnkd.in/eW9rsrRN A common way to simulate metabolism in an organism is by metabolic models -- mathematical equations that describe the dynamics of chemical reactions. Genome-scale constraint-based metabolic models account for most reactions that can occur in a cell and can be used to predict how much a genetically engineered microbe can produce an industrially relevant compound. However, a common method to simulate constraint-based metabolic models forces cellular reactions to either be optimised only for growth or only for production of the new compound -- neither of which is realistic. We solve this problem for E. coli producing citramalate by using information from another type of metabolic model to constrain the reaction fluxes in the base constraint-based model for E. coli.

🔬 At STEMCELL, we often highlight the significance of cell quality. A recent publication from the Barbaric lab at the University of Sheffield sheds light on the mechanism of how a common 1q duplication in hPSCs affects cell differentiation. 🧬 The study reveals that these abnormal hPSCs become hypersensitive to WNT signaling, thereby altering differentiation and maturation phenotypes. This is a great example of how genomic aberrations can affect downstream cell types, potentially biasing experimental interpretations. 📚 To read the full publication, click on the link: https://lnkd.in/g-bwkptZ #STEMCELL #CellQuality #GenomicAberrations #CellDifferentiation #Research #BarbaricLab #UniversityofSheffield

Together with the Institut du Cerveau – Paris Brain Institute and Violetta Zujovic's group we published a new method on how to investigate #MolecularDynamics trajectories with #trees. You can find our article here: https://lnkd.in/gbm7ih5Q #MolecularSimulartion #Simulation #Bioinformatics #StructuralBiology

What if there was a way to improve drug screening so patients had faster access to the medicine they need? What if there was a way to test therapy treatment candidates by leveraging broad genetic diversification so the outcomes are more inclusive?  With organoids, a type of 3D cell culture, these ideas have very real potential and I am proud that MilliporeSigma is supporting the scientific research community in this exciting area.  Come along with me into the lab where Spencer Keilich, Ph.D., one of our cell culture experts, helps me use a microscope to take a look at these miniature organs up close.  So, what application for organoids do you think holds the most potential to positively impact our society? #Innovation #CellCulture #Organoids #StemCellResearch #ScienceIsCool

Thanks for the great collaboration and the praise of our #CellEDIT service, Kanstantsin Siniuk! Reach out to us if you want to learn more about #genomeengineering using #FluidFM!

Ever wondered how DNA 🧬 is made at Twist Bioscience? Twist’s technical innovation gives YOU access to unlimited applications, from targeted gene therapies and the development of new diagnostics tools to sustainable chemicals and plants with improved yields. Check out the full video: https://lnkd.in/dU3aa63B  🚀 #TwistBioscience #DNASynthesis

Ever wondered how DNA 🧬 is made at Twist Bioscience? Twist’s technical innovation gives YOU access to unlimited applications, from targeted gene therapies and the development of new diagnostics tools to sustainable chemicals and plants with improved yields. Check out the full video: https://lnkd.in/dU3aa63B  🚀 #TwistBioscience #DNASynthesis