BioTechniques’ Post

QI: Why do we shiver when we aren't cold? Dr Sean Roe, our expert in physiology (and shivering), explains more. Do you have a question you've always wanted to know the answer to? Ask us and you never know, one of our experts could be answering your question next ➡️ ow.ly/jZzw50QuQHC

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PhysiologySep 2024246-344 On the cover: Molecules such as nucleic acids and proteins are the building blocks of cells. Cells are the building blocks of tissues, tissues are the building blocks of organs, and organs are the building blocks of organisms, including humans. Life manifests at different levels and constantly ascends and descends as organisms are born, age, and die, with each level having some autonomy from the others. New research suggests that life exhibits emergent properties and complexity at multiple levels of organization. Both the organism as a whole and its individual cells are systems with interrelated purposes, and death offers the potential for transformation. From: Noble PA, Pozhitkov A, Singh K, Woods E, Liu C, Levin M, Javan G, Wan J, Abouhashem AS, Mathew-Steiner SS, Sen CK. Unraveling the enigma of organismal death: insights, implications, and unexplored frontiers. Physiology (Bethesda) 39: 313-323, 2024. https://lnkd.in/g6RnpDWN.

Journal of General Physiology (JGP)'s September issue is out! https://hubs.la/Q02N4BDy0 🔬 The cover shows how two AI modules extract from a skeletal muscle EM image the pixel-wise fraction (pf) of glycogen granules. A numerical simulation derives from pf the voxel-wise fraction (vf) proportional to glycogen concentration, which decreases approximately threefold in patients susceptible to malignant hyperthermia. Eduardo Ríos et al. (https://hubs.la/Q02N4B-30) propose artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue.

New peer-review publication: Organismal death has long been considered the irreversible ending of an organism's integrated functioning as a whole. However, the persistence of functionality in organs, tissues, and cells postmortem, as seen in organ donation, raises questions about the mechanisms underlying this resilience. Recent research reveals that various factors, such as environmental conditions, metabolic activity, and inherent survival mechanisms, influence postmortem cellular functionality and transformation. These findings challenge our understanding of life and death, highlighting the potential for certain cells to grow and form new multicellular entities. This opens new avenues in biology and medicine, expanding our comprehension of life's complexity. Here is my latest review on the topic:

Noxious cold and ion channel symphony... Comparison with the noxious hot...

#JCETcollaborativePublication ‼We are excited to share our new collaborative work published in Journal of Physiology with Prof Zoladz group which questions the importance of myoglobin as a major regulator of nitric oxide (NO) bioavailability and exercise performance. 🐁Taking advantage of the unique mouse model, we showed that myoglobin deficiency impaired maximal oxygen uptake and running performance. Surprisingly, lack of myoglobin resulted in lower basal nitric oxide (NO) bioavailability both at the systemic level as well as in the locomotory muscles but did not affect NO bioavailability during exercise. 🔬🧪 📝For more details and novel insight into the regulatory role of myoglobin see: https://lnkd.in/d_7QeQ-q --- #JCETteam #JCETcaféJournalClub #science #endothelium #lab

We (David Eisner, Andrew Trafford and I) argue that if the open probability of the cardiac ryanodine receptor is altered by drugs, the effects on systolic intracellular calcium are transient. This can be accounted for by the requirement of calcium flux balance. Our latest thoughts on this subject are now published in The Journal of Physiology: https://lnkd.in/ePJSzaF5

The Reactive Species Interactome, Mitochondria, and the Gender-Brain Metabolism Nexus! Join Laurent Chatre, Université de Caen Normandie, Centre national de la recherche scientifique, France, at #RedoxMedicine2024 to learn more on this topic. Dr. Chatre will explain about the complex network of the redox system and mitochondria, highlighting the reactive species interactome and its crucial role in physiological processes. He will also present new findings on the gender effect in redox and bioenergetics studies, particularly in the brain, offering fresh insights that could reshape the future of redox medicine. 🌐 Redox Medicine 2024 Conference Details: https://lnkd.in/dkNzFQZU #RedoxMedicieSociety #RedoxMedicine2024 #biomarkers #redoxbiology #redox #antioxidants #innovation #oxidativestress #RedoxResearch

For the discovery of microRNA and its role in post-transcriptional gene regulation-Victor Ambros and Gary Ruvkun-2024 Nobel Prize winner in Physiology or Medicine Victor Ambros and Gary Ruvkun discovered microRNA, a new class of tiny RNA molecules that play a crucial role in gene regulation. Their groundbreaking discovery in the small worm C. elegans revealed a completely new principle of gene regulation. This turned out to be essential for multicellular organisms, including humans. MicroRNAs are proving to be fundamentally important for how organisms develop and function. https://lnkd.in/gTbgW2TM https://lnkd.in/dJnPExyr #MicroRNA #GeneRegulation #NobelPrize2024 #VictorAmbros #GaryRuvkun #Ceglas #PostTranscriptionalControl #RNAResearch #MolecularBiology #GeneticsRevolution #EssentialForLife #MulticellularOrganisms #kmdbioscience