Bio-Works Technologies’ Post

The new Acid-Base Selection Tool is now live! Developed by the ACS Green Chemistry Institute Pharmaceutical Roundtable, the free tool is designed to empower you to choose more sustainable acids and bases in your research. There are more than 200 acids and bases to choose from, and they are filterable by parameters including pKa, functional groups, melting point, and boiling point. The tool also contains scoring based on on environment, health, and safety (EHS) and Clean Chemistry aspects. A combined score accounting for numerous factors makes it easy to compare acid and base options. Read more on The Nexus blog, and try it out: https://brnw.ch/21wMiQJ #GreenChemistry

Pharmaceutical companies have long relied on mercury lamp-based photometry for various applications, including chromatographic separation, protein measurement, solvent concentration, product detection, trace water content, centrifuge control, and phase separation. In a significant move towards sustainability and public health, the European Union has announced a ban on mercury lamps by 2025. This decision aims to reduce environmental pollution and protect public health from the toxic effects of mercury. This regulatory change raises an important question: How will laboratories and facilities that depend on mercury filament lamps adapt? The engineering team at here Fullbrook Systems has written a blog on this subject, visit our website to read more: https://lnkd.in/e-sRa6tb #pharmaceuticals #mercurylamps #photometers

We will be exhibiting at PREP 2024, an international conference for Preparative & Process Chromatography. Join us in Philadelphia, PA, from May 28-31, 2024, for a deep dive into the latest advancements and innovations in the field. 🥳 Our specialist Yannick Krauke, Dr. will present his research on "IN-LINE TOOLS FOR SMB METHOD DEVELOPMENT IN LAB SCALE USED FOR PURIFICATION OF NATURAL COMPOUNDS." 🌿 His presentation will explore advanced techniques in liquid chromatography, focusing on the purification processes of xylitol and CBD using simulated moving bed chromatography (SMB). This method offers a more sustainable and efficient approach to purifying natural compounds. Presentation Highlights: ✅ In-line tools for SMB method development in lab scale used for purification of natural compounds ✅ Yannick Krauke ✅ Session 4A: Process Analytical Technologies PAT ✅ 05:40PM Don't miss this opportunity to gain insights from top experts, participate in interactive workshops, and explore innovative vendor exhibits. Whether you're a professional or new to the field, PREP 2024 promises to be an invaluable experience for all. See you in Philadelphia! 🇺🇸 Dr. Maximilian von Delbrück #PREP2024 #Chromatography #SMB #Xylitol #CBD #thinklc #thinkknauer

Missed the live webcast? Good news—our insightful session on how to identify unique risks to oral bioavailability and explore effective solutions is now available on demand! Discover how Lonza's innovative material-sparing techniques, such as small-scale spray drying, compaction simulation, ASAP Prime, PBPK modeling, and salt/co-crystal creation, can optimize your formulation. Learn how our formulation development process enhances bioavailability and the synergy between excipient compatibility and drug product formulation through advanced modeling tools. Featuring insights from our formulation experts Hannah Worrest, Bailey Coker, and Allison DuRoss, this session provides practical strategies for overcoming drug formulation challenges. Watch the webinar here : https://bit.ly/3OuZ997 #LonzaSM #BioavailabilityWebinar #WeWorkAsOne

Cogent® Lab Systems A family of modular and flexible systems for TFF at process development scale When developing a tangential flow filtration (TFF) step at small scale, using a model representative of large-scale performance is essential. It not only allows for the successful transfer from laboratory scale to larger volumes, but also maintains consistent process parameters. The Cogent® Lab 150, 800, and 6000 systems are optimized for high product recovery and drainability, ensuring successful small-scale TFF operations. With the ability to operate in concentration/diafiltration, microfiltration, and single pass tangential flow filtration (SPTFF) modes, our systems can accommodate a wide range of operating parameters (volume, temperature, flow) #biotech #biotechnology #pharma #biotecnologia #Merck

At #DDE, our Tangential Flow Filtration (#TFF) Systems are designed to streamline downstream bioprocessing with superior efficiency, scalability, and purity. With our TFF Systems, you get,  ✅ Maximized Product Recovery: Retain more of what matters with optimized membrane performance. ✅ Reduced Fouling & Downtime: Advanced design ensures seamless operation and longevity. ✅ Scalability & Compliance: Engineered for evolving production needs with regulatory alignment. From R&D to full-scale manufacturing, our solutions ensure faster purification, higher throughput, and minimal complexities, helping you bring life-saving biologics to market with confidence. Ready to transform your process?  Contact us! #DownstreamProcessing #BiotechInnovation #FiltrationRevolution

Brent Miller, MSc here! Ever wonder why the resins you use are ACTUALLY the ones that you SHOULD use? There is no one-size-fits-all approach to downstream process development. One of the first steps in optimizing chromatography is resin screening. This is often done at a small scale before scaling up linearly. Some key considerations include: purity, yield, and impurity clearance. By screening varied resins you can determine which ones perform better over others in these categories. This is driven by your class of protein, physiochemical interactions at a molecular level, dynamic binding capacities, bead size/composition, and load capacity of the resin itself. Choosing the right resin will enhance the efficiency of your process and reduce COGs, time, materials, labor, and provide high yield, high purity biologics. An oft-overlooked component of this optimization is buffer composition. Balancing compatibility of the aqueous protein and the resin itself can impart drastic impacts on your purity and yield. Through DoE or QbD and a little know-how, you can find your sweet spot for elution and clearance. This is an integral part of refining your statistical models. Although largely linear, when scaling up, resins may behave differently as well. Factors to consider at larger scales, informed by small scale studies, include linear flow velocity, retention of efficacy at scale, residence time, column volume/bed height/column diameter, and most importantly, facility fit restraints. If it can't be done at scale, you are wasting your resources in trying to fit a square peg in a round hole. Custom tailoring your chromatography processes to meet your specific needs, while still retaining a level of flexibility is a balancing act, and as such, is tantamount in getting your drug substance out the door to impact lives beyond the supply chain and meeting contract requirements. 🧀 📠 : Approximately 10 pounds of milk is required to make one pound of cheese.

In their latest application note, Waters Corporation demonstrates how the Arc HPLC System and Empower Software’s GPC option provide reliable analysis of PLGA, a biodegradable polymer used in drug delivery. The system makes it easy to monitor PLGA degradation over time with confidence. 📖 Read the full app note at the link below! #BiodegradablePolymers #PLGA #DrugDelivery #GPC #WatersCorporation #HPLC #AnalyticalChemistry

We are very proud to present our brand new infographic highlighting the vital role solvents play in the production of pharmaceuticals and fine chemicals! From synthesis of pharmaceuticals to purification, formulation, and even drug delivery systems, solvents are indispensable at every stage of the manufacturing process. Learn how the careful selection of solvents ensures the safety, efficacy, and quality of final products, and explore the latest trends in solvent use, including green chemistry principles and circular economy developments. Dive into real-world case studies that highlight the economic and environmental benefits of innovative solvent management practices. https://lnkd.in/ejBdxtiy

#TestoriProduct: Many of our #API producer customers face the challenge of recovering pharmaceutical ingredients in acidic environments where antistatic properties are essential. 👉🏼 Standard conductive fabrics with stainless steel filaments do not fit this application. So, how do we solve this problem? 🤔 ✔ 𝗪𝗶𝘁𝗵 𝗼𝘂𝗿 𝗽𝗼𝗹𝘆𝗽𝗿𝗼𝗽𝘆𝗹𝗲𝗻𝗲 𝗰𝗼𝗻𝗱𝘂𝗰𝘁𝗶𝘃𝗲 𝗳𝗮𝗯𝗿𝗶𝗰 𝘄𝗶𝘁𝗵 𝗰𝗮𝗿𝗯𝗼𝗻 𝘆𝗮𝗿𝗻𝘀 𝘄𝗼𝘃𝗲𝗻 𝗶𝗻 𝗯𝗼𝘁𝗵 𝘄𝗮𝗿𝗽 𝗮𝗻𝗱 𝘄𝗲𝗳𝘁 𝗱𝗶𝗿𝗲𝗰𝘁𝗶𝗼𝗻𝘀! 🧵 𝗧𝗵𝗶𝘀 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝘃𝗲 𝗺𝗮𝘁𝗲𝗿𝗶𝗮𝗹 𝗶𝘀 𝗻𝗼𝘁 𝗼𝗻𝗹𝘆 𝘄𝗶𝗱𝗲𝗹𝘆 𝗰𝗵𝗲𝗺𝗶𝗰𝗮𝗹𝗹𝘆 𝗰𝗼𝗺𝗽𝗮𝘁𝗶𝗯𝗹𝗲 𝗯𝘂𝘁 𝗮𝗹𝘀𝗼 𝗶𝗻𝗰𝗿𝗲𝗱𝗶𝗯𝗹𝘆 𝘀𝗮𝗳𝗲 𝗳𝗼𝗿 𝘂𝘀𝗲 𝗶𝗻 𝘁𝗵𝗲𝘀𝗲 𝗱𝗲𝗺𝗮𝗻𝗱𝗶𝗻𝗴 𝗰𝗼𝗻𝗱𝗶𝘁𝗶𝗼𝗻𝘀. Our fabric is perfect for various filtration applications, including disc filters and centrifuge liners. LIFEtes - Testori range for Pharma & Food #pharma #APIrecovery #innovation