Birch Biotech’s Post

Unlock the Keys to Effective Solvent Evaporation in LC-MS Analysis! #AnalyticalChemistry #LCMS #SolventEvaporation #LabEfficiency #BirchBiotech

🔬 Exciting News in Analytical Chemistry! 🔬 Are you passionate about advancing science through cutting-edge technology? Look no further! High Performance Liquid Chromatography ,the game-changer in analytical chemistry! 🌟 Join us in celebrating the marvels of HPLC, revolutionizing how we analyze compounds with unparalleled precision and efficiency. From pharmaceuticals to environmental monitoring, HPLC empowers researchers worldwide to unravel complex molecular mysteries and drive innovation. 💡 Ready to elevate your research to new heights? Explore the limitless possibilities of HPLC today! #AnalyticalChemistry #HPLC #Innovation #Science #Research

🔬 Gradient vs. Isocratic Elution in HPLC: What's the Best Fit for Your Lab? 🚀 Choosing between gradient and isocratic elution is crucial for optimizing HPLC workflows. Our latest blog dives deep into their differences, benefits, and ideal applications. Whether you aim for complex separations or consistent analysis, understanding these techniques will enhance your analytical precision. Check it out here: https://lnkd.in/ewpi2MRG Which method do you prefer for your separations? Let's discuss! 👇 #HPLC #LCMS #Gradient #isocraticelution #Chemistry #Lab #Science

HPLC Detectors: Types, Principles, and Applications High-Performance Liquid Chromatography (HPLC) has become a cornerstone in analytical chemistry, offering precision and versatility for separating and analyzing compounds. At the core of this powerful technique are HPLC detectors, which enable the identification and quantification of analytes as they elute from the chromatographic column. This guide explores HPLC detectors, their types, working principles, advancements, and wide-ranging applications. https://lnkd.in/ewnTB-MY

Did you know that Raman spectroscopy is not just for upstream applications? It’s also an excellent tool for downstream bioprocessing! In fact, Raman spectroscopy can match or even outperform HPLC, UPLC, and UV spectroscopy methods. In our latest video, we explore the use of Raman spectroscopy in downstream applications such as measuring product concentration, detecting product aggregation, assessing glycosylation, and monitoring membrane fouling. Want to dive deeper? Check out the full article by ProAnalytics LLC Senior Applications & Technical Service Engineer, Yiğit Y., and feel free to reach out to him if you have any questions! Read the full article: https://buff.ly/3xCkcl5 #Bioprocessing #RamanSpectroscopy #Biotech #DownstreamProcessing #Biopharma #ProcessAnalytics

Miniaturized LC Optimized Using HPLC-Based System High-performance liquid chromatography (HPLC) is a chromatography-based technique for separating, identifying, and quantifying components in a mixture. Transitioning from conventional liquid chromatography (LC) to miniaturized scales (capillary/nano-LC) offers not only analytical and methodological benefits, but also significant advantages in environmental, toxicological (related to analysts' health), and cost. Link: https://lnkd.in/eX93U-aF

STREAMLINE YOUR CHROMATOGRAPHY LAB WITH ESSENTIAL SUPPLIES

🧬🔬 Simplifying 2D Liquid Chromatography (LCxLC) Method Development Through a Shortcut Modeling Approach 📊🧮 Comprehensive two-dimensional liquid chromatography (LCxLC) offers a detailed analysis of complex mixtures more efficiently than traditional one-dimensional liquid chromatography (1D-LC). Despite its potential, the complexity of developing LCxLC methods often deters its widespread use. This study by Monica Tirapelle, Dian Ning Chia, Fanyi Duanmu, Maximilian Besenhard , Luca Mazzei and Eva Sorensen MBE introduces a practical shortcut model for predicting retention times and peak widths in RPLCxRPLC systems, facilitating more straightforward method development for LCxLC. 🔎 Utilizing the hydrophobic-subtraction model (HSM) for retention predictions, this model addresses common challenges like sample volume, undersampling, and pressure limits. It supports a two-step optimization strategy for selecting the best column pair and determining the ideal flow rate, pH, and sample loop volume through multi-objective stochastic optimization. Key Features: 🧬 LCxLC Method Development: Introduces a shortcut model for easier prediction of chromatographic outcomes. 📈 Accurate Predictions: Applies HSM for reliable forecasting of retention times and peak widths. 🔄 Column Selection Optimization: Uses Kendall's correlation coefficient to select optimal column pairs. ⏱ Efficient Optimization Process: Reduces method development time significantly, with optimizations taking less than two minutes. 📚 Link to Publication: https://lnkd.in/di_7CGUu #LCxLC #Chromatography #MethodDevelopment #ModelingApproach #AnalyticalChemistry #PolyModelsHub

[Process development] Mass spectrometry Part 3. This article is the final installment in our series on mass spectrometry. In the past two articles, we examined the principles and types of basic units in mass spectrometry. In this article, we will explore tandem mass spectrometry (MS/MS), which enables precise analysis of complex mixtures. Please visit our hompage via the link below to read the full article! https://lnkd.in/gZQypH7Z

We invent chemistries for chromatography ⏰Everyday / all the time! 🆕 Open Access Paper: https://lnkd.in/gpvjE_9m I’m honored to lead a team that’s as ingenious with their materials science as they are their method development skills. If you haven’t heard, we've been optimizing the inertness of widepore size exclusion chromatography (SEC), so we can help the world with an aspiration to design and manufacture efficacious and globally accessible biological drugs. Here’s a just-published paper that tells a behind-the-scenes story on how we created a new hydrophilic 3 µm 1000Å SEC particle chemistry then stabilized and protected it with bridging ethylene (BE) cross-links to improve chemical lifetime and compatibility with #MALS. Biophysical characterization, aggregate analysis, DS/DP impurity quantitation, and titer measurements - all with less time spent on method development and less time wasted waiting for each run to finish. Authors Kristine Joy Camacho, Oksana Tchoul, Yuehong Xu, Abraham Samuel Finny, Lavelay Kizekai, Justin Mclaughlin, Steven Byrd, Balasubrahmanyam Addepalli, Mingcheng Xu #GTxResolve #HPLC #MALS #vaccines #AAVs #mRNA #GeneTherapy #CellTherapy #CMC #AnalyticalChemistry #biotech Waters Corporation Waters | Wyatt Technology #LifeatWaters