Bismark Kumi’s Post

On this week reflection task of the the 3MTT, we were saddle with the responsibility to partner with a fellow to provide a solution to a problem, I and MICHAEL MESHACH decided to work on the project - Antibiotics Resistance: A Time BOMB": Project Scope This comprehensive project aims to delve into the intricacies of antibiotic resistance, exploring its far-reaching consequences, identifying key contributing factors, and examining potential solutions to mitigate its impact. The project will provide an in-depth analysis of the current situation, dissecting the complex relationships between antibiotic use, bacterial evolution, and human health. Objectives 1. To gain a profound understanding of antibiotic resistance, its mechanisms, and significance. 2. To identify and analyze the primary causes and risk factors driving antibiotic resistance. 3. To assess the multifaceted effects of antibiotic resistance on human health, economy, society, and the environment. 4. To raise awareness and promote responsible antibiotic use among healthcare professionals, policymakers, and the general public. Background Antibiotic resistance is a pressing global health concern, fueled by the overuse and misuse of antibiotics. As bacteria evolve to withstand antibiotic effects, infections become increasingly difficult to treat, leading to a surge in mortality rates, prolonged hospital stays, and skyrocketing healthcare costs. Causes 1. Overprescription and misuse of antibiotics in human medicine. 2. Lack of new antibiotic development and research. 3. Inadequate infection control practices in healthcare settings. 4. Widespread agricultural use of antibiotics in animal husbandry. Effects 1. Increased mortality rates and reduced life expectancy. 2. Prolonged hospital stays and increased healthcare costs. 3. Reduced effectiveness of treatments and surgeries. 4. Increased risk of pandemics and global health crises. 5. Economic burdens on individuals, families, and societies. 6. Environmental contamination and ecological disruption. Solutions 1. Implement robust antibiotic stewardship programs in healthcare settings. 2. Develop new antibiotics, alternative treatments, and innovative therapies. 3. Improve infection control practices, sanitation, and hygiene. 4. Reduce agricultural use of antibiotics and promote sustainable farming practices. 5. Enhance public awareness, education, and community engagement. 6. Encourage global cooperation, policy changes, and legislative actions. Data Source - WHO: Antibiotic resistance causes over 700,000 deaths annually. (Source: WHO) - CDC: Antibiotic resistance costs the US healthcare system over $20 billion annually. (Source: CDC) #My3MTT #3MTTWeeklyReflection Bernice E. Omiunu Goodness Osifo Opeyemi USMAN Amiosinor Agbomekhe MICHAEL MESHACH

🌍 Antibiotic Resistance: A Global Health Crisis and India's Call to Action at UNGA79 🌍 As the 79th session of the United Nations General Assembly approaches, the WHO is sounding the alarm on Antimicrobial Resistance (AMR) — a global threat that demands urgent action. One of the starkest examples is Tuberculosis (TB) in India, where drug-resistant TB poses a major public health challenge. 💊 India’s TB Crisis: India accounts for 26% of the world's TB cases, with over 2.5 million cases reported annually. Worryingly, India also has the highest burden of multidrug-resistant TB (MDR-TB), with over 110000 cases in 2022 alone. Drug resistance is making treatment longer and less effective, leading to increased mortality and a financial strain on both individuals and the healthcare system. 📉 TB Treatment Success Rates: In India, the treatment success rate for drug-resistant TB is just 56% and for XDR-TB is 48% compared to over 85% for drug-sensitive TB. This difference illustrates the urgent need for targeted interventions to combat AMR. What can India do to address this crisis? 🔍 Here are key areas that need focus: 1️⃣ Surveillance & Diagnostics: Improve diagnostic capacity to identify drug-resistant TB early. Currently, only 52% of MDR-TB cases in India are detected. 2️⃣ Stewardship Programs: Reduce antibiotic misuse in healthcare and agriculture. Up to 70% of antibiotics in India are used in livestock, increasing the risk of resistance. 3️⃣ Infection Control: Invest in public health infrastructure to prevent the spread of TB. Studies show that proper infection control could reduce transmission by 60%. 4️⃣ Research & Development: Increase funding for new TB treatments and diagnostics. Globally, India contributes to 20% of new TB drugs in the pipeline. 5️⃣ Community Awareness & Education: Encourage adherence to TB treatment regimens, as 17% of patients do not complete their courses, fueling resistance. At UNGA79, global leaders, including India, must act decisively. By focusing on TB, we can lead the charge in combating AMR and safeguarding public health. #AntibioticResistance #UNGA79 #TBTreatment #AMR #IndiaFightsTB #GlobalHealth #WorldHealthOrganization #PublicHealthCrisis #Stewardship #Innovation #SustainableHealthcare World Health Organization https://lnkd.in/ghr92239

The next superbug pandemic or silent pandemic can make antibiotics ineffective, with India identified as one of the most vulnerable countries. Antibiotic superbugs are bacteria resistant to multiple antibiotics, posing significant challenges in treating infections. Antibiotic resistance could escalate into a pandemic in the near future if immediate corrective measures are not implemented. Globally, India ranks highest in antibiotic consumption. According to a report released by the Union Ministry of Health and Family Welfare, about 57% of prescribed antibiotics in India fall into a category “watch antibiotics”. Generally, "Watch" antibiotics, as classified by the World Health Organization (WHO), are reserved for severe infections where other antibiotics are not effective. This category typically includes antibiotics that are critical for treating certain resistant bacteria. Health Care Providers (HCPs) sometimes prescribe antibiotics, even in cases of viral infections, to prevent secondary bacterial infections. However, it's essential for Indians to have discussions with HCPs about the importance of reducing unnecessary antibiotic use. Patients should avoid obtaining antibiotics from pharmacists without a prescription, and refrain from self-medication practices. What other strategies can be employed to effectively control antibiotic resistance?

🍁𝗔𝗻𝘁𝗶𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗮𝗹 𝗥𝗲𝘀𝗶𝘀𝘁𝗮𝗻𝗰𝗲 (𝗔𝗠𝗥) 𝗔𝘄𝗮𝗿𝗲𝗻𝗲𝘀𝘀 𝗪𝗲𝗲𝗸 (𝟭𝟴𝘁𝗵-𝟮𝟰𝘁𝗵 𝗡𝗼𝘃𝗲𝗺𝗯𝗲𝗿)  The 𝗪𝗼𝗿𝗹𝗱 𝗔𝗻𝘁𝗶𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗮𝗹 𝗥𝗲𝘀𝗶𝘀𝘁𝗮𝗻𝗰𝗲 𝗔𝘄𝗮𝗿𝗲𝗻𝗲𝘀𝘀 𝗪𝗲𝗲𝗸 (WAAW) is a global campaign that aims to raise awareness and understanding of antimicrobial resistance (AMR) and to encourage best practices to reduce the spread of drug-resistant infections. This awareness is of paramount importance to the public, One Health stakeholders, and policymakers, all of whom play a critical role in mitigating the further emergence and spread of AMR. The message is clear: "𝙀𝙙𝙪𝙘𝙖𝙩𝙚. 𝘼𝙙𝙫𝙤𝙘𝙖𝙩𝙚. 𝘼𝙘𝙩 𝙣𝙤𝙬." 🧑🔬As a researcher in the field of Infectious diseases and Antimicrobial Resistance (AMR), it is incumbent upon me to disseminate information to the general public regarding AMR and the appropriate utilization of antibiotics. AMR occurs when microorganisms, including bacteria, viruses, fungi, and parasites, evolve and cease to respond to antimicrobial agents, thereby rendering infections more challenging to treat and increasing the risk of disease transmission, severe morbidity, and mortality. Consequently, due to drug resistance, antibiotics and other antimicrobial medicines become ineffective, resulting in infections that are increasingly difficult or impossible to treat. AMR is caused by a combination of natural processes and human actions: #Natural processes Microorganisms evolve to adapt to their environments and survive. When something stops them from growing, like an antimicrobial, they can develop genetic changes that allow them to survive. #Human actions Human actions can increase the development and spread of AMR. It includes: ##Misuse and overuse of antimicrobials: This includes overprescribing antibiotics by healthcare professionals, not taking antibiotics as directed, and inappropriate use of antimicrobials ##Poor hygiene: This includes not washing hands properly, poor infection prevention and control, and unsafe food preparation ##Lack of access to clean water, sanitation, and hygiene: This includes poor access to quality, affordable medicines ##Travel: This includes traveling and receiving medical treatment overseas AMR is a global concern that threatens the ability to treat common infectious diseases. It can lead to prolonged illness, disability, and death. World Health Organization (WHO) Centers for Disease Control and Prevention World Organisation for Animal Health Indian Council of Medical Research (ICMR) Union for International Cancer Control (UICC) Wellcome Connecting Science Learning and Training Microbiology Society #AMR #One Health #Antibiotics

🌍 AMR Awareness Week: November 18-24, 2024 🌍  Antimicrobial resistance (AMR) is a global threat that impacts human and animal health, food production, and the environment. Misuse and overuse of antibiotics have accelerated this crisis, and it’s an issue I care deeply about.  Growing up, antibiotics were seen as “magic pills” in my household, a cure for nearly any ailment. I vividly remember my grandma (a university Maths professor) emptying capsules onto a spoon, mixing the powder with honey to make them palatable, and even doubling the initial dose to “start with a strong fight.” While well-intentioned, such practices exemplify the widespread misuse of antibiotics—an issue that persists even today. In 2022, I experienced this firsthand while being treated for a bacterial infection in Chongqing, China—one of the country’s largest and most developed cities. Despite visiting a reputable hospital, I wasn’t told how long to take the antibiotics. When I asked the chemist about the full course, they seemed surprised and said, *“You stop taking it when you feel better.” In the UK, awareness of AMR is significantly better, but there’s still work to do. On a couple of occasions, I’ve encountered unnecessary antibiotic prescriptions—for example, for ear pain caused by hay fever. Recently, when my daughter developed a pus-filled fingernail infection, the urgent care nurse prescribed antibiotics but kindly warned that it might not work and suggested we follow up with another antibiotic prescription. Instead, I tried soaking her finger in warm salt water and using an antiseptic cream (a situation-specific choice, not general advice). She healed in three days, and I felt great knowing we avoided antibiotics and protected her gut health.  While innovative research and initiatives are underway to tackle AMR, no one can solve this problem alone. Global partnerships and collaborative efforts are essential to drive change, foster innovation, and implement effective solutions. Let’s bring healthcare professionals, researchers, policymakers, industry leaders, and the public to champion responsible antibiotic use, support AMR-focused research, and amplify education worldwide. Only through strong partnerships can we safeguard the effectiveness of antibiotics for generations to come.  #AntimicrobialResistance #GlobalHealth #PartnershipsForChange

Antimicrobial resistance (AMR) will continue to be a significant global health threat in 2024. AMR occurs when bacteria, viruses, fungi, and parasites no longer respond to medicines, making infections harder to treat and increasing the risk of disease spread, severe illness, and death. The misuse and overuse of antimicrobials in humans, animals, and agriculture are the primary drivers of this resistance. Globally, AMR poses a severe risk, with projections indicating that drug-resistant infections could lead to 10 million deaths annually by 2050 if no significant actions are taken. The World Health Organization (WHO) has identified critical, high, and medium-priority pathogens, emphasizing the need for new treatments and international coordination to combat this issue. The WHO’s Global Antimicrobial Resistance and Use Surveillance System (GLASS) collects data from over 120 countries to track and manage the spread of resistance】. In Pakistan, AMR is a growing concern due to several factors, including inadequate regulation of antibiotic use, over-the-counter availability of antibiotics without prescriptions, and poor infection control practices in healthcare settings. The country faces challenges with drug-resistant tuberculosis, malaria, and other bacterial infections like Klebsiella pneumoniae, which shows high resistance levels to critical antibiotics】. Efforts are being made to strengthen antimicrobial stewardship, enhance surveillance systems, and improve infection prevention and control measures. Addressing AMR requires a One Health approach, integrating human, animal, and environmental health strategies. This involves improving sanitation, regulating antibiotic use, and promoting better waste management in pharmaceutical manufacturing and agriculture. Global initiatives, including collaborations between WHO, FAO, and UNEP, are essential to tackling AMR comprehensively. #AMR

Looming Threat: Antibiotic Resistance and the Urgent Need for Alternatives The world faces a critical public health challenge – the rise of antibiotic resistance. According to a multitude of leading publications, including The Telegraph, Reuters, and The Washington Post, highlighting The Lancet's recent article, antibiotic-resistant "superbugs" could claim the lives of millions by 2050. The stark reality: - Exponential Growth: Antibiotic resistance is increasing at an alarming rate, jeopardizing the effectiveness of these life-saving medications. - Global Problem, Devastating Impact: This phenomenon has the potential to impact all regions of the world, leading to increased mortality, morbidity, and healthcare costs. - Weakening Healthcare Systems: The ability to treat routine infections, conduct surgeries, and manage chronic conditions hinges on effective antibiotics. Resistance undermines these essential practices. Why are alternatives crucial? - Limited New Discoveries: The development pipeline for new antibiotic classes has slowed considerably. Overreliance on existing antibiotics accelerates resistance. - Need for Diverse Solutions: Different types of infections require specific approaches. Broad-spectrum antibiotics contribute to resistance, highlighting the need for targeted alternatives. The Path Forward: - Research and Development: Increased investment in novel antimicrobials, #bacteriophages, and immunotherapeutics is vital. - Stewardship and Prudent Use: Optimizing antibiotic prescribing practices in healthcare and agriculture plays a critical role. - Global Collaboration: International cooperation is essential to address this global threat effectively. Antibiotic resistance is a complex issue demanding a multi-faceted approach. Scientists, clinicians, policymakers, and the public must work together to combat this escalating threat. Let's prioritize research, foster responsible practices, and ensure efficient #access to #effectivealternatives. #AntibioticResistance #PublicHealth #AlternativesToAntibiotics #Healthcare Lxbio Pharmaceuticals Feel free to share your thoughts and expertise in the comments below!

As we complete the World Anti-Microbial Resistance (AMR ) Awareness Week ( 18- 24 November ) it is important to highlight it as a Growing Global Concern. AMR occurs when microorganisms develop resistance to antimicrobial drugs, making infections harder to treat. Data, Facts, and Figures: 1. 10 million deaths by 2050: AMR could claim more lives than cancer, if left unchecked. (Source: Review on Antimicrobial Resistance) 2. 70% of bacteria resistant: In India, 70% of bacteria are resistant to commonly used antibiotics. (Source: Indian Journal of Medical Research) 3. $20 trillion economic burden: AMR could cost the global economy $20 trillion by 2050. (Source: World Bank) Corrective Measures: 1. Antibiotic Stewardship: Promote responsible use of antibiotics in humans and animals. 2. Infection Prevention and Control: Implement effective IPC practices in healthcare settings. 3. Vaccination: Develop and use effective vaccines to prevent infections. 4. Research and Development: Encourage R&D of new antimicrobial drugs and diagnostics. Norms and Notifications: 1. National Action Plan on AMR: India's NAP-AMR (2017-2021) outlines strategies to combat AMR. 2. CDSCO Guidelines: Central Drugs Standard Control Organisation (CDSCO) guidelines for antibiotic use and AMR surveillance. 3. WHO Global Action Plan: World Health Organization's (WHO) global plan to combat AMR. What Can You Do? 1. Use antibiotics responsibly: Only use antibiotics when prescribed by a healthcare professional. 2. Practice good hygiene: Wash your hands regularly, especially in healthcare settings. 3. Get vaccinated: Stay up-to-date on recommended vaccinations to prevent infections. 4. Support AMR research: Encourage and support research initiatives to combat AMR. We are working with Industry Associations, Government and Pharma companies to create platforms / events / norms to Educate, Advocate and Act now. #AMR #AntiMicrobialResistance #GlobalHealth #PublicHealth #InfectionPrevention #neogensolutions #AntibioticStewardship #pragency

🚨 The Growing Threat of Resistant Microbes: A Global Health Challenge Antimicrobial resistance (AMR) is one of the biggest threats to global health today, and it’s a topic that requires urgent attention. As a microbiologist, I’ve witnessed firsthand how microbes evolve to resist the very drugs that once kept them in check. This ongoing issue puts millions of lives at risk, as common infections become harder to treat. 💡 Why is AMR a Concern? Increased Resistance: Bacteria, fungi, and viruses are increasingly becoming resistant to antibiotics, antivirals, and antifungals. This makes infections that were once easily treatable far more dangerous. Overuse and Misuse of Antibiotics: The overuse of antibiotics in both humans and animals is a key factor driving resistance. When used unnecessarily or incorrectly, they can lead to the development of drug-resistant strains. Limitations in New Drug Development: The pipeline for new antibiotics is drying up. Fewer new drugs are being developed, while resistance continues to grow. 🌍 The Impact of AMR: Prolonged Hospital Stays: Resistant infections lead to longer treatments and more complications, putting strain on healthcare systems. Higher Mortality Rates: Infections that were once treatable with antibiotics now result in increased morbidity and mortality. Economic Burden: The costs associated with AMR are staggering, not only in healthcare but also in lost productivity. 🧬 What Can We Do? Promote Responsible Antibiotic Use: Educating both healthcare professionals and the public on the importance of using antibiotics responsibly is key. Invest in Research: We need more research into new antibiotics and alternative treatments. Strengthen Infection Control: Implementing strict hygiene and infection control practices can help prevent the spread of resistant microbes. As professionals in the fields of microbiology and biotechnology, we must collaborate, innovate, and advocate for better practices to combat antimicrobial resistance. The time to act is now. 🔍 How is your organization addressing the issue of antimicrobial resistance? I’d love to hear your thoughts and solutions! #AntimicrobialResistance #AMR #PublicHealth #Microbiology #Biotechnology #HealthcareInnovation #GlobalHealth

Antimicrobial resistance (AMR ) threatens the very core of modern medicine and the sustainability of an effective, global public health response to the enduring threat from infectious diseases. Every Nation is at risk due to; systematic misuse and overuse of these drugs in human medicine and food production.have put every The world is heading towards a post-antibiotic era if no harmonised and immediate action on global scale in which common infections could once again kill. According to the May 2015 World Health Assembly adopted a global action plan on antimicrobial resistance, which outlines five objectives: 1. Enhanced awareness and understanding of antimicrobial resistance; effective communication, education and training. 2. Strengthening the knowledge and evidence base cases through surveillance and research. * 3. _Reducing the incidence of infection through improving effective sanitation, hygiene and infection prevention measures._ * 4. Optimization of the use of antimicrobial medicines in human and animal health. 5. Development of the economic case for sustainable investment that takes into account the needs of all countries towards increased investment in new medicines, diagnostic tools, vaccines and other interventions. Therefore with this approach of treatment and prevention of infectious diseases with quality-assured, safe and effective medicines is an achievable goal.