BrainTale’s Post

Did you know graft-versus-host disease (GVHD) can occur after a blood stem cell transplant? This condition happens when donor cells attack a recipient's organs and/or tissues. While it can be serious, it can also be managed. As a proud member of the GVHD Alliance, we're working together with leading transplant organizations to improve access to resources and support for patients with GVHD like Olivia. Discover more about the alliance's collective efforts and help us spread the word this coming GVHD Day 👉 https://lnkd.in/eDXmJmaQ #GVHDDay #GVHDAlliance #NMDP

🔬 Safety of Allogeneic Mesenchymal Stem Cells Mesenchymal stem cells (MSCs) hold incredible potential for clinical and therapeutic applications, with over 1,200 registered clinical trials showcasing their versatility. These trials have yielded promising results in treating diseases such as cancer, COVID-19, strokes, and autoimmune disorders, addressing critical areas with limited treatment options. Extensive analysis of prospective clinical trials involving allogeneic MSC transplantation in children and adults has revealed minimal risks. Occurrences of infusional toxicity, organ system complications, infections, and fatalities are exceedingly rare in these trials, highlighting the safety profile of allogeneic MSCs. Learn more about safe and effective Longevity interventions at www.imagine-thailand.com #StemCellTherapy #RegenerativeMedicine #Healthcare #ImagineHealth #Thailand #Safety #StemCells #Longevity #MSC #AFS

Activated PI3Kδ syndrome (#APDS) is a rare immune disorder with significant unmet needs, including misdiagnosis and delayed diagnosis. In Spain, a multidisciplinary committee evaluated APDS treatment using multicriteria decision analysis (#MCDA). Current treatments are mainly off-label and provide limited disease control, with haematopoietic stem cell transplantation being the only potential curative option but with restricted use. The study highlights APDS's high economic burden and suggests MCDA as a valuable tool for enhancing clinical and decision-making processes.| https://ow.ly/rOes50SgXrI

𝗣𝗮𝗻𝗰𝗿𝗲𝗮𝘁𝗶𝗰 𝗖𝗮𝗻𝗰𝗲𝗿 𝗔𝘄𝗮𝗿𝗲𝗻𝗲𝘀𝘀 𝗠𝗼𝗻𝘁𝗵 💜 November is #PancreaticCancer Awareness Month, a time to shine a light on one of the deadliest forms of cancer and to drive support for research, early detection, and treatment. Pancreatic cancer is often diagnosed late, making awareness and education essential to improve outcomes. 𝗪𝗵𝗮𝘁 𝘆𝗼𝘂 𝘀𝗵𝗼𝘂𝗹𝗱 𝗸𝗻𝗼𝘄: 💜 Pancreatic cancer is the 3rd leading cause of cancer-related deaths 💜 Approximately 60,000 people are diagnosed each year in the US alone 💜 Only about 10% of patients survive five years post-diagnosis due to late detection 💜 Early symptoms can include jaundice, abdominal or back pain, unintended weight loss, and digestive issues 𝗛𝗲𝗿𝗲 𝗮𝗿𝗲 𝟱 𝘀𝘁𝗮𝗿𝘁-𝘂𝗽𝘀 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗻𝗴 𝗶𝗻 𝘁𝗵𝗶𝘀 𝘀𝗽𝗮𝗰𝗲: 💜 Reccan AB – Developers of an easy-to-use #bloodtest for early detection and improve prognosis of #pancreaticcancer 💜 EndoSound – Developers of #EUS technology to detect pancreatic cancer, #coloncancer, #IBD and other #gastrointestinal disorders 💜 Galen Health – Developers of #OncoSight, #AI-powered platform for early detection of pancreatic cancer 💜 Limaca Medical Ltd Medical – Developers of #PrecisionGI, EUS guided motorized #biopsy technology for detection of pancreatic and #GI Cancers 💜 Amplified Sciences, Inc. – Developers of an assay for early detection of pancreatic cancers, as well as #kidney disease Let’s use November to increase awareness, support those affected, and push for progress in pancreatic cancer research. #PancreaticCancerAwareness #cancerawareness #PancreaticCancer #endoscopy #oncology #medtech #medicaldevices #executivesearch #recruitment #pancreas #startups #healthtech #dx #innovation 

𝗖𝗵𝗿𝗼𝗻𝗶𝗰 𝗴𝗿𝗮𝗳𝘁-𝘃𝗲𝗿𝘀𝘂𝘀-𝗵𝗼𝘀𝘁 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 (𝗰𝗚𝗩𝗛𝗗) 𝗰𝗮𝗻 𝘀𝗶𝗴𝗻𝗶𝗳𝗶𝗰𝗮𝗻𝘁𝗹𝘆 𝗶𝗺𝗽𝗮𝗰𝘁 𝗮 𝗽𝗮𝘁𝗶𝗲𝗻𝘁'𝘀 𝗾𝘂𝗮𝗹𝗶𝘁𝘆 𝗼𝗳 𝗹𝗶𝗳𝗲 𝗮𝗳𝘁𝗲𝗿 𝗮 𝘀𝘁𝗲𝗺 𝗰𝗲𝗹𝗹 𝘁𝗿𝗮𝗻𝘀𝗽𝗹𝗮𝗻𝘁. but there's hope! Incyte Corporation's axatilimab-csfr (Niktimvo) has been approved by the FDA as a new treatment for adult and pediatric patients with cGVHD who've exhausted other options. This is a major breakthrough in managing this complex condition. Axatilimab-csfr demonstrated a significant improvement in overall response rate in clinical trials, offering new hope for patients and their families. Let's celebrate this milestone in the fight against cGVHD! https://lnkd.in/g7fTX2Gs #cGVHD #OrphanDisease #NewTreatment #Hope #Incyte #Axatilimab-csfrFDAIncyte #Orphandrug

🔬 Lipid Rafts: Unveiling Cellular Microdomains for New Therapeutic Possibilities 🧬 Lipid rafts are specialized microdomains within the plasma membrane, rich in cholesterol and sphingolipids, that play an essential role in cellular functions. From immune responses to cell communication, these dynamic structures influence processes like signal transduction and membrane trafficking. 📲🧫 Research is shedding light on how lipid rafts contribute to diseases like cancer, neurodegenerative disorders, and viral infections. Understanding their role opens doors to innovative treatments that can disrupt or harness these microdomains for targeted therapies. #LipidRafts #CellularBiology #MembraneDynamics #MedicalResearch #InnovativeTherapies #BioScience # biobypriti

🌟Periodic fasting aids intestinal stem cell repair and regeneration but poses a potential cancer risk in mice🌟.. Recent research has explored the effects of periodic fasting on intestinal health, particularly focusing on stem cell regeneration and cancer risk. Studies in mice have shown that fasting can enhance the regenerative capacity of intestinal stem cells, aiding in the healing of injuries. However, this increased regenerative activity may also elevate the risk of developing precancerous lesions in the intestine. It's important to note that these findings are based on animal studies, and their applicability to humans remains uncertain. The human body's response to fasting is complex, and more research is needed to fully understand the potential benefits and risks. If you're considering incorporating fasting into your routine, it's advisable to consult with a healthcare professional to ensure it's appropriate for your individual health circumstances. #pharmacy #stemcell #cancer #mice #pharmd

Not every patient responds to drugs in the same way 💊 . This may be due to differences in DNA. The structure of genes in DNA can make certain drugs work faster or slower. This is why geneticists are now creating a profile that can be used to determine exactly what patients' expected sensitivity is to certain medication. It will become available to our haematology patients this month. In cancer treatments such as stem cell therapy or CAR-T cell therapy, incorrect starting doses can have consequences. Haematologist 👩⚕️ Carolien Woolthuis expects a lot from the DNA profile: ‘It shows which dosage best suits the patient. That can make all the difference.' 👍 Geneticists Jackie Dekens and Lude Franke will investigate whether it can also be applied to patients with other conditions, such as cardiovascular disease. They will also investigate whether healthy individuals can also benefit. 'We want to know whether all the information is clear and whether participants also want to share it with their healthcare providers. And we would like to investigate whether it makes sense to make such a DNA profile of everyone.' Curious to find out more? ➡ https://lnkd.in/eTQpj--Q #haematology, #dna #lifelines

🌟Watch our on-demand webinar on the therapeutic potential of Regulatory T cells (Tregs)!🌟 Access it here: https://lnkd.in/gMS5-Wyy Tregs are essential for maintaining immune balance and preventing autoimmune diseases like lupus and graft-versus-host disease. Discover how expanding Tregs can restore this balance and offer a promising therapeutic approach. Learn about the technology that ensures high-fold expansion of suppressive Tregs with a stable FOXP3 phenotype and robust suppressive function. Key takeaways: 🔹 Achieve >800-fold expansion of Tregs after two stimulations 🔹 Activate and expand Tregs in a closed, automated system 🔹 Explore the potential of CAR-engineered Tregs in treating autoimmune diseases, organ transplants, and stem cell transplantation #Immunotherapy #Webinar #Tregs #AutoimmuneDisease #Transplantation #MedicalResearch

Label-free live cell imaging technology 🔍 Here capturing two glioblastoma cells undergoing autophagy, revealing all the intricate details of the process.