California Life Sciences (CLS)’s Post

This week Aanastra Inc and DIVINCELL will be at the Advancing Gene and Cell Therapies for Cancer Conference (American Society of Gene & Cell Therapy), taking place October 16-17, 2024, in Philadelphia,. https://lnkd.in/eswMGcxg We will present our RNA-based therapeutic platform to target aberrant genetic disorders and oncogenes in cancer  ▶ "mRNA-mediated Rescue of Lost Tumor Suppressor Function in Mutated p53 or BRCA1 Tumors is a Potent New Strategy for Cancer Therapy Delivered with Tumor-Targeted Peptide (non-LNP) Nanoparticles ". Abstract 24. ▶ "In Vivo CRISPR Gene Editing of KRAS Mutant Tumors with Tumor-Targeted (non-LNP) Peptide-based Nanoparticles Causes Strong Tumor Regressions with Only 2 Doses and Overcomes Resistance to Existing Small-Molecule KRAS Inhibitors". Abstract 25. #p53 #KRAS #CRISPR #BRCA-1 #BRCAness #nanotechnology #drugdelivery #mRNA #ASGCTAdvancing24 #ASGCT #geneediting

#HighlyCitedPapers 📝 Gene Expression Profiling in Early Breast Cancer—Patient Stratification Based on Molecular and Tumor Microenvironment Features — Munkácsy et al. In this paper, the authors aimed to evaluate the current evidence of using #gene expression signatures or profiling (GEP) in clinic and explore and discuss the increasing importance of immune parameters and the possibility to refine current tools with additional immune-GEPs that may help to refine prognosis and provide better predictive tools for early-stage breast #cancer. Full text is available 👇 https://lnkd.in/dxvmVf2x #medicine #health #research #science

Discover how integrating spatial transcriptomics (ST) and bulk RNA-Seq provides unprecedented insights into the tumor microenvironment of non-small cell lung cancer (NSCLC). This study reveals the power of these techniques in understanding gene expression profiles, refining target expression by cell type, and identifying variability within tumors. Download our poster to learn more about this innovative approach and its potential for personalized therapeutic strategies. https://hubs.la/Q02zQzhl0 #NSCLC #SpatialTranscriptomics #RNASeq #PersonalizedMedicine

Discover the Cutting-Edge of cancer research: Dive into our detailed poster on Spatial Transcriptomics and learn how these groundbreaking technologies are revolutionizing our understanding of NSCLC. #CancerResearch #NSCLC #SpatialTranscriptomics #RNAseq #LearnMore

🚀 CRISPR 🤝 CAR T 🚀 An exciting advancement in CAR T-cell therapy has been achieved by using CRISPR to knock out the CD5 gene. This critical novelty enhances CAR T function in both liquid and solid cancer models by boosting T cell signaling, cytotoxicity, and persistence 🤩 It's fascinating to see that the researchers report CD5 KO outperforms PD-1 KO, a commonly pursued strategy, in both liquid and solid cancer models. Link to paper in comments 👇 #CARTcell #CRISPR #CancerResearch #Immunotherapy #ScienceNews

🔬 Understanding DNA Methylation in Cancer: An Essential Insight! 🧬🔎 Explore the crucial role of DNA methylation in cancer development and progression. 🦠✨ 📚 Gain valuable knowledge about epigenetic control and its impact on gene expression. 🔬 Learn about liquid biopsies, biomarkers, and the potential of cell-free DNA in cancer research. 🌟 Stay updated with the latest advancements in diagnostic, prognostic, and treatment response monitoring. Read more: https://lnkd.in/gbET2qPP #DNAMethylation #CancerResearch #LiquidBiopsies #Biomarkers #Epigenetics #Science #Healthcare

The CTNNB1 gene encodes beta-catenin, a dual function protein involved in regulation and coordination of cell-cell adhesion and gene transcription. It is also involved in cell signaling. Somatic mutations in the CTNNB1 gene are associated with many cancers, including desmoids tumors, a low-grade tumor occurring in the connective tissue that are highly invasive but generally do not metastasize. The mutations are also observed in Wilms tumor, a rare kidney cancer that affects children. Learn more about the testing with Medical Database. https://lnkd.in/dceX6evR #medicaldatabase

Unpacking A Treasure Chest Of Knowledge In #BreastCancer https://lnkd.in/eFxdRTDs What Is Genomic Testing? Genomic testing represents a significant leap forward in understanding breast cancer. This innovative approach examines the gene expression inside the #tumor. Gene expression helps us understand how cancer cells are growing and developing. Unlike genetic testing, which focuses on inherited traits, genomic testing delves into the cancer itself, uncovering the story written in the tumor’s gene activity, specifically how the cancer cells are growing and developing DNA. This narrative reveals how #cancer grows, spreads, and, most importantly, guides which treatments might be most effective. #sposnorAgendiaAgendia #cancerawareness #breastcancerawareness #oncology #oncologist #cancerctreatment

New Gene Discovery Could Halt Metastatic Cancer Spread Metastatic cancer cells, which cause 90% of cancer-related deaths, must overcome numerous hurdles to spread from a primary tumor through the bloodstream and re-establish themselves in different tissues. A new study led by investigators from the Mass General Cancer Center has identified a gene whose expression confers a growth advantage to these cells. Expression of Gstt1 enables the cells to change the surrounding environment to support their growth. The findings could lead to new strategies to treat metastatic cancer and would be particularly impactful for patients with pancreatic cancer. #gene #cancer #pancreatic #growth #tumor #bloodstream #tissues #cells #treat #Gstt1 #halt #spread #healthcare #health

Immunotherapy is evolving, and electroporation is at its heart. Discover how this advanced technology is shaping the future of cancer therapy, from high-efficiency gene editing to the optimization of cell viability and function in our first Cell Therapy eBook. https://buff.ly/3VV0mvA