CancerFree KIDS’ Post

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Fantastic news for our kids! We are proud to have played a small part in this important work.

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Professor of Pediatrics

So excited to share that the FDA allowed our IND this week for Universal Donor CD38KO CD33CAR-NK cells for AML! These CAR-NK cells with site-directed insertion mediated by CRISPR and AAV have been a major objective defined by our 5-year strategic plan and a “first” for us in so many aspects. They represent a major new build on Nationwide Children's Hospital's established platform of allogeneic cell therapy. Special thanks to Michelle Watts, Elizabeth George, and Prithy Martis, who have lived at the tip of this spear for the last 3+ years, and congrats to Meisam Naeimi Kararoudi who generated the first laboratory data in May, 2020. Looking forward to the first patient treated in 2025! Thrilled, relieved, exhausted, grateful, and encouraged all at once!

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