Cannabinoid Translational Science’s Post

🎉 The 4th Transatlantic ECI #GPCR #Symposium works together with American Society for Pharmacology and Experimental Therapeutics - ASPET and offers participating ECIs the option to publish their work 🧾 in a special issue of #MolecularPharmacology to highlight the research of junior scientist in the field 🥳

🌟 Exciting research update from our lab! 🌟 We are thrilled to announce that our collaborative study titled "The DOAC Dipstick Reliably Excludes Residual FXa Inhibitors Levels in the Preoperative Setting" has been accepted for publication in Thrombosis Research. This study represents a significant advancement in the field of anticoagulation management, providing a rapid and reliable method for detecting residual FXa inhibitors in preoperative settings. The DOAC Dipstick can potentially enhance patient safety and improve clinical outcomes. 👏 Special acknowledgment goes to Julie Vassart, one of my PhD student at the Université de Namur in the Clinical Pharmacology and Toxicology Research Unit (URPC), whose hard work and dedication were crucial to this project's success. This research was made possible through the collaborative efforts of DOASENSE GmbH, NorthShore University HealthSystem, University of Chicago, Loyola University Chicago, and Heidelberg University. We are grateful for the support and contributions from all involved institutions. 📚 Read more about our findings below ⬇️ #Research #Collaboration #Anticoagulation #HealthcareInnovation #Clinicalresearch #Thrombosisresearch ---

Glad to be back in Cambridge on an other sunny day! It was an interesting and inspiring Session 2 of the Clinical Pharmacology Training with Michael (Michalis) Kostapanos, MD, PhD, DHP, FRCP, FFPM, FRSPH , Oscar Della Pasqua , Jayne Marshall, David Wright, Andrew Buchanan FRSC and all the participants from different areas. Thank you all! 👉 Dose calculation and dose escalation plan: NOAEL vs MABEL - implication of drug candidate pharmacology. 👉PK in humans, dose-response relationship, therapeutic index, safety margin. 👉 Statistical design in clinical development. 👉 Engineering smart antibody molecules.

Every researcher feels that publishing their first article is a novel experience. By the grace of Almighty, I published my very first article about the prevalence of antibiotic resistance of staphylococcus aureus in waste waters in renowned journal of population therapeutics and clinical pharmacology. Kindly find the article in the link below 👇⬇️ https://lnkd.in/dZQi-Tgu #antibioticresistance #clinical #staphalococcusaureus #research #researchgate #wastewater

This paper aims to show the application of reinforcement learning (RL) for precision dosing and the benefits of integrating PK/PD models as simulation engines in the core of the RL-based precision doing algorithm, by reviewing the most relevant works in this field. The authors concluded that several works theoretically demonstrate that the integration of RL and computational models, especially pharmacokinetic-pharmacodynamic models, can support and improve precision dosing tasks. Published in Clinical Pharmacology & Therapeutics. Read the full study: https://hubs.ly/Q02LsR9z0 | #PrecisionMedicine #PrecisionDosing #Pharmacokinetics #Pharmacodynamics #PKPD

📢 Register for the upcoming DiMe webinar on October 30, 11am EDT: Regulatory Pathways for Qualification and Acceptance of Digital Health Technology-Derived Clinical Trial Endpoints: Considerations for Sponsors and join Jessie Bakker, MS PhD and Elena Izmailova as they discuss the available regulatory approaches to support the increasing deployment of DHTs within the clinical research setting and to help advance regulatory science in the field of digital medicine, based on the recent publication in American Society for Clinical Pharmacology & Therapeutics' Journal. Read the article here:  https://lnkd.in/eDGy_QBs REGISTER HERE for the webinar👇 https://lnkd.in/eZEPAebt #DiMe #journalclub #DHT #drugdevelopment #Regulatory

I am honored to be part of this webinar with Dr. Mai Mehanna, MS, PhD and Dr. Liang Zhao to share some tips to increase the chance of publishing your exciting discovery in Clinical Pharmacology & Therapeutics (#CPT)!

Join us in this webinar to learn more about the common mistakes that lead to manuscript rejection in CPT Journal and how you can avoid them and produce high quality research work

I’m pleased to announce the publication of our latest research article in the British Journal of Clinical Pharmacology. This study investigates the innovative use of pharmacokinetic-pharmacodynamic (PKPD) modeling to optimize parathyroid hormone (PTH) therapy for individuals with hypoparathyroidism. By personalizing treatment strategies, we aim to enhance patient outcomes and address the limitations of current therapies, paving the way for improved management of this condition. A huge thank you to my co-authors, Manon Schuls-Fouchier, Annika Berends, Anneke Muller Kobold, Nieko Punt, Daan Touw, for their expertise, collaboration, and insights! 🙌 I’m excited to continue advancing this research, focusing on the development of a sustained-release formulation for PTH to achieve the outcomes demonstrated in our PKPD study. https://lnkd.in/dSnjPbiM

A Phathom-sponsored study was recently published in American Society for Clinical Pharmacology & Therapeutics’ journal CPT: Pharmacometrics & Systems Pharmacology, diving further into the relationship between acid suppression and healing rates.  The paper presents the largest dataset on gastric pH and erosive esophagitis treatment outcomes from multiple published studies, as well as the first published mathematical model-based simulation linking pH holding time to healing for potassium-competitive acid blockers (PCABs), proton pump inhibitors (PPIs) and histamine H2-receptor antagonists (H2RAs). The model confirmed that PCABs provide superior and more consistent pH control, and higher erosive esophagitis healing rates, than PPIs and H2RAs. All conclusions are based on a mathematical model derived from multiple data points from various studies and are not the results of a clinical trial. Read the full study to learn more: https://bit.ly/3U9EgDX #PSPJournal #ASCPTJournalFamily